A novel purification method in organic synthesis using hydrogen bonding

B.W.T. Gruijters; J.M.M. Verkade; F.L. Delft, van; R.P. Sijbesma; P.H.H. Hermkens; F.P.J.T. Rutjes

doi:10.1002/ejoc.200700242

A novel purification method in organic synthesis using hydrogen bonding

B.W.T. Gruijters, J.M.M. Verkade, F.L. Delft, van, R.P. Sijbesma, P.H.H. Hermkens, F.P.J.T. Rutjes

Research output: Contribution to journal › Article › Academic › peer-review

4 Citations (Scopus)

Abstract

A new workup and purification method based on quadruple hydrogen-bonding interactions is reported. Substrates containing a hydrogen-bonding affinity tag - either directly connected or through a cleavable linker - were conveniently separated from a reaction mixture and purified using a resin containing self-complementary affinity tags. Several Ugi products and nucleophilic aromatic substitution products were successfully purified by this hydrogen-bonding-based affinity-separation protocol.

Original language	English
Pages (from-to)	4197-4204
Journal	European Journal of Organic Chemistry
Volume	2007
Issue number	25
DOIs	https://doi.org/10.1002/ejoc.200700242
Publication status	Published - 2007

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title = "A novel purification method in organic synthesis using hydrogen bonding",

abstract = "A new workup and purification method based on quadruple hydrogen-bonding interactions is reported. Substrates containing a hydrogen-bonding affinity tag - either directly connected or through a cleavable linker - were conveniently separated from a reaction mixture and purified using a resin containing self-complementary affinity tags. Several Ugi products and nucleophilic aromatic substitution products were successfully purified by this hydrogen-bonding-based affinity-separation protocol.",

author = "B.W.T. Gruijters and J.M.M. Verkade and {Delft, van}, F.L. and R.P. Sijbesma and P.H.H. Hermkens and F.P.J.T. Rutjes",

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AU - Gruijters, B.W.T.

AU - Verkade, J.M.M.

AU - Delft, van, F.L.

AU - Sijbesma, R.P.

AU - Hermkens, P.H.H.

AU - Rutjes, F.P.J.T.

PY - 2007

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AB - A new workup and purification method based on quadruple hydrogen-bonding interactions is reported. Substrates containing a hydrogen-bonding affinity tag - either directly connected or through a cleavable linker - were conveniently separated from a reaction mixture and purified using a resin containing self-complementary affinity tags. Several Ugi products and nucleophilic aromatic substitution products were successfully purified by this hydrogen-bonding-based affinity-separation protocol.

U2 - 10.1002/ejoc.200700242

DO - 10.1002/ejoc.200700242

M3 - Article

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VL - 2007

SP - 4197

EP - 4204

JO - European Journal of Organic Chemistry

JF - European Journal of Organic Chemistry

IS - 25

ER -

A novel purification method in organic synthesis using hydrogen bonding

Abstract

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