A novel purification method in organic synthesis using hydrogen bonding

B.W.T. Gruijters, J.M.M. Verkade, F.L. Delft, van, R.P. Sijbesma, P.H.H. Hermkens, F.P.J.T. Rutjes

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)


A new workup and purification method based on quadruple hydrogen-bonding interactions is reported. Substrates containing a hydrogen-bonding affinity tag - either directly connected or through a cleavable linker - were conveniently separated from a reaction mixture and purified using a resin containing self-complementary affinity tags. Several Ugi products and nucleophilic aromatic substitution products were successfully purified by this hydrogen-bonding-based affinity-separation protocol.
Original languageEnglish
Pages (from-to)4197-4204
JournalEuropean Journal of Organic Chemistry
Issue number25
Publication statusPublished - 2007


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