A novel method to transfer porous PDMS membranes for high throughput Organ-on-Chip and Lab-on-Chip assembly

W.F. Quiros-Solano; N. Gaio; C. Silvestri; Y.B. Arik; O.M.J.A. Stassen; A.D. van der Meer; C.V.C. Bouten; A. van den Berg; R. Dekker; P.M. Sarro

doi:10.1109/MEMSYS.2018.8346550

A novel method to transfer porous PDMS membranes for high throughput Organ-on-Chip and Lab-on-Chip assembly

W.F. Quiros-Solano, N. Gaio, C. Silvestri, Y.B. Arik, O.M.J.A. Stassen, A.D. van der Meer, C.V.C. Bouten, A. van den Berg, R. Dekker, P.M. Sarro

Soft Tissue Biomech. & Tissue Eng.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

1 Citation (Scopus)

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Abstract

We present a novel method to easily and reliably transfer highly porous, large area, thin microfabricated Polydimethylsiloxane (PDMS) porous membranes on Lab-on-Chip (LOC) and Organ-on-Chip (OOC) devices. The use of silicon as carrier substrate and a water-soluble sacrificial layer allows a simple and reproducible transfer of the membranes to any PDMS-based OOC and LOC device. The use of IC and MEMS compatible techniques reduces significantly the fabrication time and the need of manual handling. Our method is suitable for automatic assembling systems, such as pick-and-place, crucial to significantly increase the throughput of OOC and LOC devices assembling. Membranes with 8 μm pore size and as thin as 4 μm are successfully transferred. The viability and biocompatibility of the transfer was assessed by culturing two different cell lines on an OOC with transferred porous PDMS membranes.

Original language	English
Title of host publication	2018 IEEE Micro Electro Mechanical Systems, MEMS 2018
Place of Publication	Piscataway
Publisher	Institute of Electrical and Electronics Engineers
Pages	318-321
Number of pages	4
ISBN (Electronic)	9781538647820
DOIs	https://doi.org/10.1109/MEMSYS.2018.8346550
Publication status	Published - 24 Apr 2018
Event	31st IEEE International Conference on Micro Electro Mechanical Systems (MEMS2018) - Belfast, United Kingdom Duration: 21 Jan 2018 → 25 Jan 2018

Conference

Conference	31st IEEE International Conference on Micro Electro Mechanical Systems (MEMS2018)
Abbreviated title	MEMS2018
Country/Territory	United Kingdom
City	Belfast
Period	21/01/18 → 25/01/18

Funding

The authors gratefully acknowledge the technical support and advice of the staff at the Else Kooi Lab, MIRA and BME laboratories at TU/e. This work was a pilot project under the framework of the NanoInside: Organs-on-Chips Technology Platform, a subsidy promoted by hDMT and granted by NanoNextNL. William F. Quirós-Solano is partially financed by Instituto Tecnológico de Costa Rica. Nikolas Gaio is financed by Electronic Components and Systems for European Leadership (ECSEL) “InForMed” (No.2014-2-662155).

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10.1109/MEMSYS.2018.8346550

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Quiros-Solano, W. F., Gaio, N., Silvestri, C., Arik, Y. B., Stassen, O. M. J. A., van der Meer, A. D., Bouten, C. V. C., van den Berg, A., Dekker, R., & Sarro, P. M. (2018). A novel method to transfer porous PDMS membranes for high throughput Organ-on-Chip and Lab-on-Chip assembly. In 2018 IEEE Micro Electro Mechanical Systems, MEMS 2018 (pp. 318-321). Institute of Electrical and Electronics Engineers. https://doi.org/10.1109/MEMSYS.2018.8346550

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abstract = "We present a novel method to easily and reliably transfer highly porous, large area, thin microfabricated Polydimethylsiloxane (PDMS) porous membranes on Lab-on-Chip (LOC) and Organ-on-Chip (OOC) devices. The use of silicon as carrier substrate and a water-soluble sacrificial layer allows a simple and reproducible transfer of the membranes to any PDMS-based OOC and LOC device. The use of IC and MEMS compatible techniques reduces significantly the fabrication time and the need of manual handling. Our method is suitable for automatic assembling systems, such as pick-and-place, crucial to significantly increase the throughput of OOC and LOC devices assembling. Membranes with 8 μm pore size and as thin as 4 μm are successfully transferred. The viability and biocompatibility of the transfer was assessed by culturing two different cell lines on an OOC with transferred porous PDMS membranes.",

author = "W.F. Quiros-Solano and N. Gaio and C. Silvestri and Y.B. Arik and O.M.J.A. Stassen and {van der Meer}, A.D. and C.V.C. Bouten and {van den Berg}, A. and R. Dekker and P.M. Sarro",

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doi = "10.1109/MEMSYS.2018.8346550",

language = "English",

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booktitle = "2018 IEEE Micro Electro Mechanical Systems, MEMS 2018",

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Quiros-Solano, WF, Gaio, N, Silvestri, C, Arik, YB, Stassen, OMJA, van der Meer, AD, Bouten, CVC, van den Berg, A, Dekker, R & Sarro, PM 2018, A novel method to transfer porous PDMS membranes for high throughput Organ-on-Chip and Lab-on-Chip assembly. in 2018 IEEE Micro Electro Mechanical Systems, MEMS 2018. Institute of Electrical and Electronics Engineers, Piscataway, pp. 318-321, 31st IEEE International Conference on Micro Electro Mechanical Systems (MEMS2018), Belfast, United Kingdom, 21/01/18. https://doi.org/10.1109/MEMSYS.2018.8346550

A novel method to transfer porous PDMS membranes for high throughput Organ-on-Chip and Lab-on-Chip assembly. / Quiros-Solano, W.F.; Gaio, N.; Silvestri, C. et al.
2018 IEEE Micro Electro Mechanical Systems, MEMS 2018. Piscataway: Institute of Electrical and Electronics Engineers, 2018. p. 318-321.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

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AU - Quiros-Solano, W.F.

AU - Gaio, N.

AU - Silvestri, C.

AU - Arik, Y.B.

AU - Stassen, O.M.J.A.

AU - van der Meer, A.D.

AU - Bouten, C.V.C.

AU - van den Berg, A.

AU - Dekker, R.

AU - Sarro, P.M.

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N2 - We present a novel method to easily and reliably transfer highly porous, large area, thin microfabricated Polydimethylsiloxane (PDMS) porous membranes on Lab-on-Chip (LOC) and Organ-on-Chip (OOC) devices. The use of silicon as carrier substrate and a water-soluble sacrificial layer allows a simple and reproducible transfer of the membranes to any PDMS-based OOC and LOC device. The use of IC and MEMS compatible techniques reduces significantly the fabrication time and the need of manual handling. Our method is suitable for automatic assembling systems, such as pick-and-place, crucial to significantly increase the throughput of OOC and LOC devices assembling. Membranes with 8 μm pore size and as thin as 4 μm are successfully transferred. The viability and biocompatibility of the transfer was assessed by culturing two different cell lines on an OOC with transferred porous PDMS membranes.

AB - We present a novel method to easily and reliably transfer highly porous, large area, thin microfabricated Polydimethylsiloxane (PDMS) porous membranes on Lab-on-Chip (LOC) and Organ-on-Chip (OOC) devices. The use of silicon as carrier substrate and a water-soluble sacrificial layer allows a simple and reproducible transfer of the membranes to any PDMS-based OOC and LOC device. The use of IC and MEMS compatible techniques reduces significantly the fabrication time and the need of manual handling. Our method is suitable for automatic assembling systems, such as pick-and-place, crucial to significantly increase the throughput of OOC and LOC devices assembling. Membranes with 8 μm pore size and as thin as 4 μm are successfully transferred. The viability and biocompatibility of the transfer was assessed by culturing two different cell lines on an OOC with transferred porous PDMS membranes.

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ER -

A novel method to transfer porous PDMS membranes for high throughput Organ-on-Chip and Lab-on-Chip assembly

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