A Novel HR-pQCT image Registration Approach Reveals Sex-Specific Changes In Cortical Bone Retraction With Aging

Bert van Rietbergen (Corresponding author), Emmanuel Biver, Thierry Chevalley, Keita Ito, Roland Chapurlat, Serge Ferrari

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Abstract

During aging, changes in endosteal and periosteal boundaries of cortical bone occur that differ between men and women. We here develop a new procedure that uses high-resolution peripheral quantitative CT (HR-pQCT) imaging and 3D registration to identify such changes within the timescale of longitudinal studies. A first goal was to test the sensitivity of the approach. A second goal was to assess differences in periosteal/endosteal expansion over time between men and women. Rigid 3D registration was used to transform baseline and all follow-up (FU) images to a common reference configuration for which the region consisting of complete slices (largest common height) was determined. Periosteal and endosteal contours were transformed to the reference position to determine the net periosteal and endosteal expansion distances. To test the sensitivity, images from a short-term reproducibility study were used (15 female, aged 21 to 47 years, scanned three times). To test differences between men and women, images from a subset of the Geneva Retirees Cohort were used (248 female, 61 male, average age 65 years, 3.5 and 7 years FU). The sensitivity study indicated a least significant change for detecting periosteal/endosteal expansion of 41/31 microns for the radius and 17/26 microns for the tibia. Results of the cohort study showed significant net endosteal retraction only in females at the radius and tibia after 3.5 years (38.0 and 38.4 microns, respectively) that further increased at 7 years FU (70.4 and 70.8 microns, respectively). No significant net periosteal changes were found for males or females at 7 years. The results demonstrate that it is possible to measure changes in endosteal contours in longitudinal studies within several years. For the investigated cohort, significant endosteal retraction was found in females but not in males. Whether these changes in cortical geometry are related to fracture risk remains to be investigated in larger cohorts © 2021 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).

Original languageEnglish
Pages (from-to)1351-1363
Number of pages13
JournalJournal of Bone and Mineral Research
Volume36
Issue number7
Early online date16 Mar 2021
DOIs
Publication statusPublished - Jul 2021

Bibliographical note

© 2021 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).

Funding

This Geneva Retirees Cohort was supported by grants from the Geneva University Hospitals and Faculty of Medicine Clinical Research Center, the HUG Private Foundation, the BNP‐Paribas Foundation, and the Fondation pour la Recherche sur l'Ostéoporose et les Maladies Osseuses de Genève. This Geneva Retirees Cohort was supported by grants from the Geneva University Hospitals and Faculty of Medicine Clinical Research Center, the HUG Private Foundation, the BNP-Paribas Foundation, and the Fondation pour la Recherche sur l'Ost?oporose et les Maladies Osseuses de Gen?ve. Authors' roles: Conceptualization and investigation: BvR, EB, TC, RC, and SF. Data curation and formal analysis: BvR, EB, and TC. Methodology, software, project administration, validation, visualization, and writing?original draft preparation: BvR. Resources: EB, TC, KI, RC, and SF. Supervision: KI. Writing?review and editing: EB, TC, KI, RC, and SF. Author contributions: BvR: Conceptualization; data curation; formal analysis; investigation; methodology; project administration; software; validation; visualization; writing-original draft. EB: Conceptualization; data curation; formal analysis; investigation; resources; writing-review & editing. TC: Conceptualization; data curation; formal analysis; investigation; resources; writing-review & editing. KI: Resources; supervision; writing-review & editing. RC: Conceptualization; investigation; resources; writing-review & editing. SF: Conceptualization; investigation; resources; writing-review & editing.

FundersFunder number
BNP‐Paribas Foundation
BNP‐Paribas Foundation
Faculty of Medicine Clinical Research Center
Fondation pour la Recherche
Fondation pour la Recherche sur l'Ostéoporose et les Maladies Osseuses de Genève
HUG Private Foundation
University Hospitals of Geneva

    Keywords

    • AGING
    • BONE QCT/mu CT
    • CLINICAL TRIALS
    • OSTEOPOROSIS
    • BIOMECHANICS
    • BONE QCT/μCT

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