A novel 3D model system to study deformation-induced cytoskeletal remodeling

J. Foolen; F. Baaijens

doi:10.1115/SBC2011-53510

A novel 3D model system to study deformation-induced cytoskeletal remodeling

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

Abstract

Native fibrous tissues contain complex anisotropic matrices. This results in essential direction-dependent mechanical properties, primarily originating from the fibrillar collagen. When engineering fibrous tissues in vitro, matrix anisotropy is crucial for in vivo functionality and durability. However, it is not fully understood how to guide, maintain and control matrix anisotropy. Cell traction and associated cell orientation may contribute significantly to collagen orientation. Therefore, the ability to manipulate cell orientation may be essential to develop a preferred matrix anisotropy for tissue engineering applications.

Original language	English
Title of host publication	ASME 2011 Summer Bioengineering Conference, SBC 2011
Pages	1161-1162
Number of pages	2
Edition	PARTS A AND B
DOIs	https://doi.org/10.1115/SBC2011-53510
Publication status	Published - 1 Dec 2011
Event	ASME 2011 Summer Bioengineering Conference, SBC 2011 - Farmington, United States Duration: 22 Jun 2011 → 25 Jun 2011 http://www.asmeconferences.org/sbc2011/

Conference

Conference	ASME 2011 Summer Bioengineering Conference, SBC 2011
Abbreviated title	SBC 2011
Country/Territory	United States
City	Farmington
Period	22/06/11 → 25/06/11
Other
Internet address	http://www.asmeconferences.org/sbc2011/

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10.1115/SBC2011-53510

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abstract = "Native fibrous tissues contain complex anisotropic matrices. This results in essential direction-dependent mechanical properties, primarily originating from the fibrillar collagen. When engineering fibrous tissues in vitro, matrix anisotropy is crucial for in vivo functionality and durability. However, it is not fully understood how to guide, maintain and control matrix anisotropy. Cell traction and associated cell orientation may contribute significantly to collagen orientation. Therefore, the ability to manipulate cell orientation may be essential to develop a preferred matrix anisotropy for tissue engineering applications.",

author = "J. Foolen and F. Baaijens",

year = "2011",

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doi = "10.1115/SBC2011-53510",

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AU - Baaijens, F.

PY - 2011/12/1

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N2 - Native fibrous tissues contain complex anisotropic matrices. This results in essential direction-dependent mechanical properties, primarily originating from the fibrillar collagen. When engineering fibrous tissues in vitro, matrix anisotropy is crucial for in vivo functionality and durability. However, it is not fully understood how to guide, maintain and control matrix anisotropy. Cell traction and associated cell orientation may contribute significantly to collagen orientation. Therefore, the ability to manipulate cell orientation may be essential to develop a preferred matrix anisotropy for tissue engineering applications.

AB - Native fibrous tissues contain complex anisotropic matrices. This results in essential direction-dependent mechanical properties, primarily originating from the fibrillar collagen. When engineering fibrous tissues in vitro, matrix anisotropy is crucial for in vivo functionality and durability. However, it is not fully understood how to guide, maintain and control matrix anisotropy. Cell traction and associated cell orientation may contribute significantly to collagen orientation. Therefore, the ability to manipulate cell orientation may be essential to develop a preferred matrix anisotropy for tissue engineering applications.

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M3 - Conference contribution

AN - SCOPUS:84881223737

SN - 9780791854587

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BT - ASME 2011 Summer Bioengineering Conference, SBC 2011

T2 - ASME 2011 Summer Bioengineering Conference, SBC 2011

Y2 - 22 June 2011 through 25 June 2011

ER -

A novel 3D model system to study deformation-induced cytoskeletal remodeling

Abstract

Conference

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