A novel 3D model system to study deformation-induced cytoskeletal remodeling

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Abstract

Native fibrous tissues contain complex anisotropic matrices. This results in essential direction-dependent mechanical properties, primarily originating from the fibrillar collagen. When engineering fibrous tissues in vitro, matrix anisotropy is crucial for in vivo functionality and durability. However, it is not fully understood how to guide, maintain and control matrix anisotropy. Cell traction and associated cell orientation may contribute significantly to collagen orientation. Therefore, the ability to manipulate cell orientation may be essential to develop a preferred matrix anisotropy for tissue engineering applications.
Original languageEnglish
Title of host publicationASME 2011 Summer Bioengineering Conference, SBC 2011
Pages1161-1162
Number of pages2
EditionPARTS A AND B
DOIs
Publication statusPublished - 1 Dec 2011
EventASME 2011 Summer Bioengineering Conference (SBC 2011) - Farmington, United States
Duration: 22 Jun 201125 Jun 2011
http://www.asmeconferences.org/sbc2011/

Conference

ConferenceASME 2011 Summer Bioengineering Conference (SBC 2011)
Abbreviated titleSBC 2011
CountryUnited States
CityFarmington
Period22/06/1125/06/11
Other
Internet address

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