A NIR light-triggered drug delivery system using core-shell gold nanostars-mesoporous silica nanoparticles based on multiphoton absorption photo-dissociation of 2-nitrobenzyl PEG

Andy Hernández-Montoto, Mónica Gorbe, Antoni Llopis-Lorente, José Manuel Terrés, Roberto Montes, Roberto Cao-Milán, Borja DÍaz De Greñu, María Alfonso, Mar Orzaez, María Dolores Marcos, Ramón Martínez-Máñez (Corresponding author), Félix Sancenón

Research output: Contribution to journal › Article › Academic › peer-review

9 Citations (Scopus)

Abstract

Gold nanostars coated with a mesoporous silica shell and functionalized with poly(ethylene glycol) containing photolabile 2-nitrobenzyl moieties are able to release doxorubicin after NIR light irradiation at low power irradiance via a multiphoton absorption photo-dissociation process.

Original languageEnglish
Pages (from-to)9039-9042
Number of pages4
JournalChemical Communications
Volume55
Issue number61
DOIs
Publication statusPublished - 7 Aug 2019
Externally publishedYes

Keywords

  • Antineoplastic Agents/pharmacology
  • Doxorubicin/pharmacology
  • Drug Carriers/chemical synthesis
  • Drug Liberation
  • Gold/chemistry
  • HeLa Cells
  • Humans
  • Infrared Rays
  • Metal Nanoparticles/chemistry
  • Nitrobenzenes/chemical synthesis
  • Polyethylene Glycols/chemical synthesis
  • Porosity
  • Silicon Dioxide/chemistry

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