Abstract
We report the first supramolecular stabilizers of the interaction between 14-3-3ζ and two of its effectors, Tau and C-Raf, which are involved in neurodegenerative diseases and proliferative signal transduction, respectively. These supramolecular ligands open up an opportunity to modulate functions of 14-3-3 with these effectors.
Language | English |
---|---|
Pages | 111-114 |
Number of pages | 4 |
Journal | Chemical Communications |
Volume | 55 |
Issue number | 1 |
DOIs | |
State | Published - 1 Jan 2019 |
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A new class of supramolecular ligands stabilizes 14-3-3 protein-protein interactions by up to two orders of magnitude. / Gigante, A.; Grad, J. N.; Briels, J.; Bartel, M.; Hoffmann, D.; Ottmann, C.; Schmuck, C.
In: Chemical Communications, Vol. 55, No. 1, 01.01.2019, p. 111-114.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - A new class of supramolecular ligands stabilizes 14-3-3 protein-protein interactions by up to two orders of magnitude
AU - Gigante,A.
AU - Grad,J. N.
AU - Briels,J.
AU - Bartel,M.
AU - Hoffmann,D.
AU - Ottmann,C.
AU - Schmuck,C.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - We report the first supramolecular stabilizers of the interaction between 14-3-3ζ and two of its effectors, Tau and C-Raf, which are involved in neurodegenerative diseases and proliferative signal transduction, respectively. These supramolecular ligands open up an opportunity to modulate functions of 14-3-3 with these effectors.
AB - We report the first supramolecular stabilizers of the interaction between 14-3-3ζ and two of its effectors, Tau and C-Raf, which are involved in neurodegenerative diseases and proliferative signal transduction, respectively. These supramolecular ligands open up an opportunity to modulate functions of 14-3-3 with these effectors.
UR - http://www.scopus.com/inward/record.url?scp=85058766650&partnerID=8YFLogxK
U2 - 10.1039/c8cc07946c
DO - 10.1039/c8cc07946c
M3 - Article
VL - 55
SP - 111
EP - 114
JO - Chemical Communications
T2 - Chemical Communications
JF - Chemical Communications
SN - 1359-7345
IS - 1
ER -