A new class of supramolecular ligands stabilizes 14-3-3 protein-protein interactions by up to two orders of magnitude

A. Gigante, J. N. Grad, J. Briels, M. Bartel, D. Hoffmann (Corresponding author), C. Ottmann (Corresponding author), C. Schmuck (Corresponding author)

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Abstract

We report the first supramolecular stabilizers of the interaction between 14-3-3ζ and two of its effectors, Tau and C-Raf, which are involved in neurodegenerative diseases and proliferative signal transduction, respectively. These supramolecular ligands open up an opportunity to modulate functions of 14-3-3 with these effectors.

LanguageEnglish
Pages111-114
Number of pages4
JournalChemical Communications
Volume55
Issue number1
DOIs
StatePublished - 1 Jan 2019

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Neurodegenerative diseases
14-3-3 Proteins
Signal transduction
Ligands
Proteins

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Gigante, A. ; Grad, J. N. ; Briels, J. ; Bartel, M. ; Hoffmann, D. ; Ottmann, C. ; Schmuck, C./ A new class of supramolecular ligands stabilizes 14-3-3 protein-protein interactions by up to two orders of magnitude. In: Chemical Communications. 2019 ; Vol. 55, No. 1. pp. 111-114
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Gigante, A, Grad, JN, Briels, J, Bartel, M, Hoffmann, D, Ottmann, C & Schmuck, C 2019, 'A new class of supramolecular ligands stabilizes 14-3-3 protein-protein interactions by up to two orders of magnitude' Chemical Communications, vol. 55, no. 1, pp. 111-114. DOI: 10.1039/c8cc07946c

A new class of supramolecular ligands stabilizes 14-3-3 protein-protein interactions by up to two orders of magnitude. / Gigante, A.; Grad, J. N.; Briels, J.; Bartel, M.; Hoffmann, D. (Corresponding author); Ottmann, C. (Corresponding author); Schmuck, C. (Corresponding author).

In: Chemical Communications, Vol. 55, No. 1, 01.01.2019, p. 111-114.

Research output: Contribution to journalArticleAcademicpeer-review

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