A new class of supramolecular ligands stabilizes 14-3-3 protein-protein interactions by up to two orders of magnitude

A. Gigante, J. N. Grad, J. Briels, M. Bartel, D. Hoffmann (Corresponding author), C. Ottmann (Corresponding author), C. Schmuck (Corresponding author)

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Abstract

We report the first supramolecular stabilizers of the interaction between 14-3-3ζ and two of its effectors, Tau and C-Raf, which are involved in neurodegenerative diseases and proliferative signal transduction, respectively. These supramolecular ligands open up an opportunity to modulate functions of 14-3-3 with these effectors.

Original languageEnglish
Pages (from-to)111-114
Number of pages4
JournalChemical Communications
Volume55
Issue number1
DOIs
Publication statusPublished - 4 Jan 2019

Keywords

  • 14-3-3 Proteins/chemistry
  • Binding Sites
  • Dimerization
  • Humans
  • Ligands
  • Molecular Dynamics Simulation
  • Neurodegenerative Diseases/metabolism
  • Protein Binding
  • Protein Stability
  • Protein Structure, Tertiary
  • Proto-Oncogene Proteins c-raf/chemistry
  • Signal Transduction
  • tau Proteins/chemistry

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