A new class of supramolecular ligands stabilizes 14-3-3 protein-protein interactions by up to two orders of magnitude

A. Gigante, J. N. Grad, J. Briels, M. Bartel, D. Hoffmann, C. Ottmann, C. Schmuck

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

We report the first supramolecular stabilizers of the interaction between 14-3-3ζ and two of its effectors, Tau and C-Raf, which are involved in neurodegenerative diseases and proliferative signal transduction, respectively. These supramolecular ligands open up an opportunity to modulate functions of 14-3-3 with these effectors.

LanguageEnglish
Pages111-114
Number of pages4
JournalChemical Communications
Volume55
Issue number1
DOIs
StatePublished - 1 Jan 2019

Fingerprint

Neurodegenerative diseases
14-3-3 Proteins
Signal transduction
Ligands
Proteins

Cite this

Gigante, A. ; Grad, J. N. ; Briels, J. ; Bartel, M. ; Hoffmann, D. ; Ottmann, C. ; Schmuck, C./ A new class of supramolecular ligands stabilizes 14-3-3 protein-protein interactions by up to two orders of magnitude. In: Chemical Communications. 2019 ; Vol. 55, No. 1. pp. 111-114
@article{265c44c1516d4b95a4785a48b80d97e9,
title = "A new class of supramolecular ligands stabilizes 14-3-3 protein-protein interactions by up to two orders of magnitude",
abstract = "We report the first supramolecular stabilizers of the interaction between 14-3-3ζ and two of its effectors, Tau and C-Raf, which are involved in neurodegenerative diseases and proliferative signal transduction, respectively. These supramolecular ligands open up an opportunity to modulate functions of 14-3-3 with these effectors.",
author = "A. Gigante and Grad, {J. N.} and J. Briels and M. Bartel and D. Hoffmann and C. Ottmann and C. Schmuck",
year = "2019",
month = "1",
day = "1",
doi = "10.1039/c8cc07946c",
language = "English",
volume = "55",
pages = "111--114",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "1",

}

Gigante, A, Grad, JN, Briels, J, Bartel, M, Hoffmann, D, Ottmann, C & Schmuck, C 2019, 'A new class of supramolecular ligands stabilizes 14-3-3 protein-protein interactions by up to two orders of magnitude' Chemical Communications, vol. 55, no. 1, pp. 111-114. DOI: 10.1039/c8cc07946c

A new class of supramolecular ligands stabilizes 14-3-3 protein-protein interactions by up to two orders of magnitude. / Gigante, A.; Grad, J. N.; Briels, J.; Bartel, M.; Hoffmann, D.; Ottmann, C.; Schmuck, C.

In: Chemical Communications, Vol. 55, No. 1, 01.01.2019, p. 111-114.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - A new class of supramolecular ligands stabilizes 14-3-3 protein-protein interactions by up to two orders of magnitude

AU - Gigante,A.

AU - Grad,J. N.

AU - Briels,J.

AU - Bartel,M.

AU - Hoffmann,D.

AU - Ottmann,C.

AU - Schmuck,C.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - We report the first supramolecular stabilizers of the interaction between 14-3-3ζ and two of its effectors, Tau and C-Raf, which are involved in neurodegenerative diseases and proliferative signal transduction, respectively. These supramolecular ligands open up an opportunity to modulate functions of 14-3-3 with these effectors.

AB - We report the first supramolecular stabilizers of the interaction between 14-3-3ζ and two of its effectors, Tau and C-Raf, which are involved in neurodegenerative diseases and proliferative signal transduction, respectively. These supramolecular ligands open up an opportunity to modulate functions of 14-3-3 with these effectors.

UR - http://www.scopus.com/inward/record.url?scp=85058766650&partnerID=8YFLogxK

U2 - 10.1039/c8cc07946c

DO - 10.1039/c8cc07946c

M3 - Article

VL - 55

SP - 111

EP - 114

JO - Chemical Communications

T2 - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 1

ER -

Gigante A, Grad JN, Briels J, Bartel M, Hoffmann D, Ottmann C et al. A new class of supramolecular ligands stabilizes 14-3-3 protein-protein interactions by up to two orders of magnitude. Chemical Communications. 2019 Jan 1;55(1):111-114. Available from, DOI: 10.1039/c8cc07946c

Access to Document