A new class of supramolecular ligands stabilizes 14-3-3 protein-protein interactions by up to two orders of magnitude

A. Gigante; J. N. Grad; J. Briels; M. Bartel; D. Hoffmann; C. Ottmann; C. Schmuck

doi:10.1039/c8cc07946c

A new class of supramolecular ligands stabilizes 14-3-3 protein-protein interactions by up to two orders of magnitude

A. Gigante, J. N. Grad, J. Briels, M. Bartel, D. Hoffmann (Corresponding author), C. Ottmann (Corresponding author), C. Schmuck (Corresponding author)

Chemical Biology

Research output: Contribution to journal › Article › Academic › peer-review

7 Citations (Scopus)

Abstract

We report the first supramolecular stabilizers of the interaction between 14-3-3ζ and two of its effectors, Tau and C-Raf, which are involved in neurodegenerative diseases and proliferative signal transduction, respectively. These supramolecular ligands open up an opportunity to modulate functions of 14-3-3 with these effectors.

Original language	English
Pages (from-to)	111-114
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	1
DOIs	https://doi.org/10.1039/c8cc07946c
Publication status	Published - 4 Jan 2019

Keywords

14-3-3 Proteins/chemistry
Binding Sites
Dimerization
Humans
Ligands
Molecular Dynamics Simulation
Neurodegenerative Diseases/metabolism
Protein Binding
Protein Stability
Protein Structure, Tertiary
Proto-Oncogene Proteins c-raf/chemistry
Signal Transduction
tau Proteins/chemistry

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10.1039/c8cc07946c

Cite this

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title = "A new class of supramolecular ligands stabilizes 14-3-3 protein-protein interactions by up to two orders of magnitude",

abstract = "We report the first supramolecular stabilizers of the interaction between 14-3-3ζ and two of its effectors, Tau and C-Raf, which are involved in neurodegenerative diseases and proliferative signal transduction, respectively. These supramolecular ligands open up an opportunity to modulate functions of 14-3-3 with these effectors.",

keywords = "14-3-3 Proteins/chemistry, Binding Sites, Dimerization, Humans, Ligands, Molecular Dynamics Simulation, Neurodegenerative Diseases/metabolism, Protein Binding, Protein Stability, Protein Structure, Tertiary, Proto-Oncogene Proteins c-raf/chemistry, Signal Transduction, tau Proteins/chemistry",

author = "A. Gigante and Grad, {J. N.} and J. Briels and M. Bartel and D. Hoffmann and C. Ottmann and C. Schmuck",

year = "2019",

month = jan,

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doi = "10.1039/c8cc07946c",

language = "English",

volume = "55",

pages = "111--114",

journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry",

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A new class of supramolecular ligands stabilizes 14-3-3 protein-protein interactions by up to two orders of magnitude. / Gigante, A.; Grad, J. N.; Briels, J.; Bartel, M.; Hoffmann, D. (Corresponding author); Ottmann, C. (Corresponding author); Schmuck, C. (Corresponding author).

In: Chemical Communications, Vol. 55, No. 1, 04.01.2019, p. 111-114.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - A new class of supramolecular ligands stabilizes 14-3-3 protein-protein interactions by up to two orders of magnitude

AU - Gigante, A.

AU - Grad, J. N.

AU - Briels, J.

AU - Bartel, M.

AU - Hoffmann, D.

AU - Ottmann, C.

AU - Schmuck, C.

PY - 2019/1/4

Y1 - 2019/1/4

N2 - We report the first supramolecular stabilizers of the interaction between 14-3-3ζ and two of its effectors, Tau and C-Raf, which are involved in neurodegenerative diseases and proliferative signal transduction, respectively. These supramolecular ligands open up an opportunity to modulate functions of 14-3-3 with these effectors.

AB - We report the first supramolecular stabilizers of the interaction between 14-3-3ζ and two of its effectors, Tau and C-Raf, which are involved in neurodegenerative diseases and proliferative signal transduction, respectively. These supramolecular ligands open up an opportunity to modulate functions of 14-3-3 with these effectors.

KW - 14-3-3 Proteins/chemistry

KW - Binding Sites

KW - Dimerization

KW - Humans

KW - Ligands

KW - Molecular Dynamics Simulation

KW - Neurodegenerative Diseases/metabolism

KW - Protein Binding

KW - Protein Stability

KW - Protein Structure, Tertiary

KW - Proto-Oncogene Proteins c-raf/chemistry

KW - Signal Transduction

KW - tau Proteins/chemistry

UR - http://www.scopus.com/inward/record.url?scp=85058766650&partnerID=8YFLogxK

U2 - 10.1039/c8cc07946c

DO - 10.1039/c8cc07946c

M3 - Article

C2 - 30515494

AN - SCOPUS:85058766650

VL - 55

SP - 111

EP - 114

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 1

ER -

A new class of supramolecular ligands stabilizes 14-3-3 protein-protein interactions by up to two orders of magnitude

Abstract

Keywords

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