Abstract
We report the first supramolecular stabilizers of the interaction between 14-3-3ζ and two of its effectors, Tau and C-Raf, which are involved in neurodegenerative diseases and proliferative signal transduction, respectively. These supramolecular ligands open up an opportunity to modulate functions of 14-3-3 with these effectors.
| Original language | English |
|---|---|
| Pages (from-to) | 111-114 |
| Number of pages | 4 |
| Journal | Chemical Communications |
| Volume | 55 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 4 Jan 2019 |
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Keywords
- 14-3-3 Proteins/chemistry
- Binding Sites
- Dimerization
- Humans
- Ligands
- Molecular Dynamics Simulation
- Neurodegenerative Diseases/metabolism
- Protein Binding
- Protein Stability
- Protein Structure, Tertiary
- Proto-Oncogene Proteins c-raf/chemistry
- Signal Transduction
- tau Proteins/chemistry
Cite this
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A new class of supramolecular ligands stabilizes 14-3-3 protein-protein interactions by up to two orders of magnitude. / Gigante, A.; Grad, J. N.; Briels, J.; Bartel, M.; Hoffmann, D. (Corresponding author); Ottmann, C. (Corresponding author); Schmuck, C. (Corresponding author).
In: Chemical Communications, Vol. 55, No. 1, 04.01.2019, p. 111-114.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - A new class of supramolecular ligands stabilizes 14-3-3 protein-protein interactions by up to two orders of magnitude
AU - Gigante, A.
AU - Grad, J. N.
AU - Briels, J.
AU - Bartel, M.
AU - Hoffmann, D.
AU - Ottmann, C.
AU - Schmuck, C.
PY - 2019/1/4
Y1 - 2019/1/4
N2 - We report the first supramolecular stabilizers of the interaction between 14-3-3ζ and two of its effectors, Tau and C-Raf, which are involved in neurodegenerative diseases and proliferative signal transduction, respectively. These supramolecular ligands open up an opportunity to modulate functions of 14-3-3 with these effectors.
AB - We report the first supramolecular stabilizers of the interaction between 14-3-3ζ and two of its effectors, Tau and C-Raf, which are involved in neurodegenerative diseases and proliferative signal transduction, respectively. These supramolecular ligands open up an opportunity to modulate functions of 14-3-3 with these effectors.
KW - 14-3-3 Proteins/chemistry
KW - Binding Sites
KW - Dimerization
KW - Humans
KW - Ligands
KW - Molecular Dynamics Simulation
KW - Neurodegenerative Diseases/metabolism
KW - Protein Binding
KW - Protein Stability
KW - Protein Structure, Tertiary
KW - Proto-Oncogene Proteins c-raf/chemistry
KW - Signal Transduction
KW - tau Proteins/chemistry
UR - http://www.scopus.com/inward/record.url?scp=85058766650&partnerID=8YFLogxK
U2 - 10.1039/c8cc07946c
DO - 10.1039/c8cc07946c
M3 - Article
C2 - 30515494
AN - SCOPUS:85058766650
VL - 55
SP - 111
EP - 114
JO - Chemical Communications
JF - Chemical Communications
SN - 1359-7345
IS - 1
ER -