Abstract
We report the first supramolecular stabilizers of the interaction between 14-3-3ζ and two of its effectors, Tau and C-Raf, which are involved in neurodegenerative diseases and proliferative signal transduction, respectively. These supramolecular ligands open up an opportunity to modulate functions of 14-3-3 with these effectors.
Original language | English |
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Pages (from-to) | 111-114 |
Number of pages | 4 |
Journal | Chemical Communications |
Volume | 55 |
Issue number | 1 |
DOIs | |
Publication status | Published - 4 Jan 2019 |
Keywords
- 14-3-3 Proteins/chemistry
- Binding Sites
- Dimerization
- Humans
- Ligands
- Molecular Dynamics Simulation
- Neurodegenerative Diseases/metabolism
- Protein Binding
- Protein Stability
- Protein Structure, Tertiary
- Proto-Oncogene Proteins c-raf/chemistry
- Signal Transduction
- tau Proteins/chemistry