A new class of supramolecular ligands stabilizes 14-3-3 protein-protein interactions by up to two orders of magnitude

A. Gigante, J. N. Grad, J. Briels, M. Bartel, D. Hoffmann (Corresponding author), C. Ottmann (Corresponding author), C. Schmuck (Corresponding author)

Research output: Contribution to journal › Article › Academic › peer-review

1 Citation (Scopus)

Abstract

We report the first supramolecular stabilizers of the interaction between 14-3-3ζ and two of its effectors, Tau and C-Raf, which are involved in neurodegenerative diseases and proliferative signal transduction, respectively. These supramolecular ligands open up an opportunity to modulate functions of 14-3-3 with these effectors.

LanguageEnglish
Pages111-114
Number of pages4
JournalChemical Communications
Volume55
Issue number1
DOIs
StatePublished - 1 Jan 2019

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Neurodegenerative diseases
14-3-3 Proteins
Signal transduction
Ligands
Proteins

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Gigante, A. ; Grad, J. N. ; Briels, J. ; Bartel, M. ; Hoffmann, D. ; Ottmann, C. ; Schmuck, C./ A new class of supramolecular ligands stabilizes 14-3-3 protein-protein interactions by up to two orders of magnitude. In: Chemical Communications. 2019 ; Vol. 55, No. 1. pp. 111-114
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Gigante, A, Grad, JN, Briels, J, Bartel, M, Hoffmann, D, Ottmann, C & Schmuck, C 2019, 'A new class of supramolecular ligands stabilizes 14-3-3 protein-protein interactions by up to two orders of magnitude' Chemical Communications, vol. 55, no. 1, pp. 111-114. DOI: 10.1039/c8cc07946c

A new class of supramolecular ligands stabilizes 14-3-3 protein-protein interactions by up to two orders of magnitude. / Gigante, A.; Grad, J. N.; Briels, J.; Bartel, M.; Hoffmann, D. (Corresponding author); Ottmann, C. (Corresponding author); Schmuck, C. (Corresponding author).

In: Chemical Communications, Vol. 55, No. 1, 01.01.2019, p. 111-114.

Research output: Contribution to journal › Article › Academic › peer-review

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Gigante A, Grad JN, Briels J, Bartel M, Hoffmann D, Ottmann C et al. A new class of supramolecular ligands stabilizes 14-3-3 protein-protein interactions by up to two orders of magnitude. Chemical Communications. 2019 Jan 1;55(1):111-114. Available from, DOI: 10.1039/c8cc07946c

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