Abstract
Objective: Our objective was to unravel the dynamics underlying spike-and-wave discharges (SWDs) characteristic for childhood absence epilepsy. Methods: SWDs were recorded for a cohort of 28 children using magnetoencephalography. Non-linear association analyses and a graph theoretical metric of local connectedness (LoC) were utilized in a sliding window starting one s before till four s after ictal onset. Results: A focal pattern of bilateral frontal and parietal areas with high LoC during the spikes alternated by generalized patterns during the waves was found for all children studied during generalization of the SWDs. In the interval preceding the generalization a focal parietal region was most often (16/28) encountered and less often an occipital (4/28), temporal (5/28) or frontal (3/28) region. 55% of the children with a parietal/occipital focal onset became seizure free after the administration of two anti-epileptic drugs, and only 12.5% with a temporal/frontal focal onset. Conclusions: The transition from the interictal to the ictal state is for some of the children characterized by dominant LoC at either the parietal/occipital and for others at the frontal/temporal region. Significance: The focal onset of the SWDs varies in location among the children with a clinical similar profile, who, however, seemingly are differing with regard to seizure control.
| Original language | English |
|---|---|
| Pages (from-to) | 1611-1619 |
| Number of pages | 9 |
| Journal | Clinical Neurophysiology |
| Volume | 130 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 1 Sep 2019 |
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Keywords
- Childhood absence epilepsy
- Driving sources
- Local connectivity mapping
- Treatment response
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A network approach to investigate the bi-hemispheric synchrony in absence epilepsy. / Ossenblok, Pauly (Corresponding author); van Houdt, Petra; Colon, Albert; Stroink, Hans; van Luijtelaar, Gilles.
In: Clinical Neurophysiology, Vol. 130, No. 9, 01.09.2019, p. 1611-1619.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - A network approach to investigate the bi-hemispheric synchrony in absence epilepsy
AU - Ossenblok, Pauly
AU - van Houdt, Petra
AU - Colon, Albert
AU - Stroink, Hans
AU - van Luijtelaar, Gilles
PY - 2019/9/1
Y1 - 2019/9/1
N2 - Objective: Our objective was to unravel the dynamics underlying spike-and-wave discharges (SWDs) characteristic for childhood absence epilepsy. Methods: SWDs were recorded for a cohort of 28 children using magnetoencephalography. Non-linear association analyses and a graph theoretical metric of local connectedness (LoC) were utilized in a sliding window starting one s before till four s after ictal onset. Results: A focal pattern of bilateral frontal and parietal areas with high LoC during the spikes alternated by generalized patterns during the waves was found for all children studied during generalization of the SWDs. In the interval preceding the generalization a focal parietal region was most often (16/28) encountered and less often an occipital (4/28), temporal (5/28) or frontal (3/28) region. 55% of the children with a parietal/occipital focal onset became seizure free after the administration of two anti-epileptic drugs, and only 12.5% with a temporal/frontal focal onset. Conclusions: The transition from the interictal to the ictal state is for some of the children characterized by dominant LoC at either the parietal/occipital and for others at the frontal/temporal region. Significance: The focal onset of the SWDs varies in location among the children with a clinical similar profile, who, however, seemingly are differing with regard to seizure control.
AB - Objective: Our objective was to unravel the dynamics underlying spike-and-wave discharges (SWDs) characteristic for childhood absence epilepsy. Methods: SWDs were recorded for a cohort of 28 children using magnetoencephalography. Non-linear association analyses and a graph theoretical metric of local connectedness (LoC) were utilized in a sliding window starting one s before till four s after ictal onset. Results: A focal pattern of bilateral frontal and parietal areas with high LoC during the spikes alternated by generalized patterns during the waves was found for all children studied during generalization of the SWDs. In the interval preceding the generalization a focal parietal region was most often (16/28) encountered and less often an occipital (4/28), temporal (5/28) or frontal (3/28) region. 55% of the children with a parietal/occipital focal onset became seizure free after the administration of two anti-epileptic drugs, and only 12.5% with a temporal/frontal focal onset. Conclusions: The transition from the interictal to the ictal state is for some of the children characterized by dominant LoC at either the parietal/occipital and for others at the frontal/temporal region. Significance: The focal onset of the SWDs varies in location among the children with a clinical similar profile, who, however, seemingly are differing with regard to seizure control.
KW - Childhood absence epilepsy
KW - Driving sources
KW - Local connectivity mapping
KW - Treatment response
UR - http://www.scopus.com/inward/record.url?scp=85068839923&partnerID=8YFLogxK
U2 - 10.1016/j.clinph.2019.05.034
DO - 10.1016/j.clinph.2019.05.034
M3 - Article
C2 - 31319290
AN - SCOPUS:85068839923
VL - 130
SP - 1611
EP - 1619
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
SN - 1388-2457
IS - 9
ER -