A modular organic neuromorphic spiking circuit for retina-inspired sensory coding and neurotransmitter-mediated neural pathways

Giovanni Maria Matrone; Eveline R.W. van Doremaele; Abhijith Surendran; Zachary Laswick; Sophie Griggs; Gang Ye; Iain McCulloch; Francesca Santoro; Jonathan Rivnay; Yoeri van de Burgt

doi:10.1038/s41467-024-47226-3

A modular organic neuromorphic spiking circuit for retina-inspired sensory coding and neurotransmitter-mediated neural pathways

Giovanni Maria Matrone (Corresponding author), Eveline R.W. van Doremaele, Abhijith Surendran, Zachary Laswick, Sophie Griggs, Gang Ye, Iain McCulloch, Francesca Santoro, Jonathan Rivnay, Yoeri van de Burgt (Corresponding author)

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Abstract

Signal communication mechanisms within the human body rely on the transmission and modulation of action potentials. Replicating the interdependent functions of receptors, neurons and synapses with organic artificial neurons and biohybrid synapses is an essential first step towards merging neuromorphic circuits and biological systems, crucial for computing at the biological interface. However, most organic neuromorphic systems are based on simple circuits which exhibit limited adaptability to both external and internal biological cues, and are restricted to emulate only specific the functions of an individual neuron/synapse. Here, we present a modular neuromorphic system which combines organic spiking neurons and biohybrid synapses to replicate a neural pathway. The spiking neuron mimics the sensory coding function of afferent neurons from light stimuli, while the neuromodulatory activity of interneurons is emulated by neurotransmitters-mediated biohybrid synapses. Combining these functions, we create a modular connection between multiple neurons to establish a pre-processing retinal pathway primitive.

Original language	English
Article number	2868
Number of pages	9
Journal	Nature Communications
Volume	15
Issue number	1
DOIs	https://doi.org/10.1038/s41467-024-47226-3
Publication status	Published - 3 Apr 2024

Funding

E.R.W.D. and Y.v.d.B. acknowledge financial support from The European Union\u2019s Horizon 2020 Research and Innovation Programme, grant agreement no. 802615. This research was funded in part, by the European Union\u2019s Horizon 2020 research and innovation programme under grant agreement n\u00B0952911, project BOOSTER, grant agreement n\u00B0862474, project RoLA-FLEX and grant agreement n\u00B0101007084 CITYSOLAR, as well as EPSRC Project EP/T026219/1 EP/W017091/1. We gratefully acknowledge Alberto Salleo as a source of inspiration for the spiking circuit approach. The authors thank Bastiaan de Jong and Lucio Cin\u00E0 of Cicci Research who helped with the design and implementation of the the custom post processing code for the Arkeo platform.

Funders	Funder number
Horizon 2020 Framework Programme	862474, 952911, 802615, 101007084
Engineering and Physical Sciences Research Council	EP/T026219/1 EP/W017091/1

Keywords

Humans
Neurons/physiology
Action Potentials/physiology
Interneurons
Neurons, Afferent
Synapses/physiology
Neurotransmitter Agents

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Matrone, G. M., van Doremaele, E. R. W., Surendran, A., Laswick, Z., Griggs, S., Ye, G., McCulloch, I., Santoro, F., Rivnay, J., & van de Burgt, Y. (2024). A modular organic neuromorphic spiking circuit for retina-inspired sensory coding and neurotransmitter-mediated neural pathways. Nature Communications, 15(1), Article 2868. https://doi.org/10.1038/s41467-024-47226-3

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A modular organic neuromorphic spiking circuit for retina-inspired sensory coding and neurotransmitter-mediated neural pathways. / Matrone, Giovanni Maria (Corresponding author); van Doremaele, Eveline R.W.; Surendran, Abhijith et al.
In: Nature Communications, Vol. 15, No. 1, 2868, 03.04.2024.

Research output: Contribution to journal › Article › Academic › peer-review

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A modular organic neuromorphic spiking circuit for retina-inspired sensory coding and neurotransmitter-mediated neural pathways

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