Abstract
Described herein is an effective and practical modular flow design for the meta-selective C-H arylation of anilines. The design consists of four continuous-flow modules (i.e., diaryliodonium salt synthesis, meta-selective C-H arylation, inline copper extraction, and aniline deprotection) which can be operated either individually or consecutively to provide direct access to meta-arylated anilines. With a total residence time of 1 hour, the desired product could be obtained in high yield and excellent purity without the need for column chromatography, and the residual copper content meets the standards for parenterally administered pharmaceutical substances.
| Original language | English |
|---|---|
| Pages (from-to) | 7161-7165 |
| Number of pages | 5 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 56 |
| Issue number | 25 |
| DOIs | |
| Publication status | Published - 12 Jun 2017 |
Keywords
- C−H activation
- arylation
- copper
- flow chemistry
- hypervalent compounds
Fingerprint Dive into the research topics of 'A modular flow design for the meta-selective C-H arylation of anilines'. Together they form a unique fingerprint.
Cite this
Gemoets, H. P. L., Laudadio, G., Verstraete, K., Hessel, V., & Noël, T. (2017). A modular flow design for the meta-selective C-H arylation of anilines. Angewandte Chemie - International Edition, 56(25), 7161-7165. https://doi.org/10.1002/anie.201703369