A modular flow design for the meta-selective C-H arylation of anilines

H.P.L. Gemoets, G. Laudadio, K. Verstraete, V. Hessel, T. Noël

Research output: Contribution to journalArticleAcademicpeer-review

36 Citations (Scopus)
107 Downloads (Pure)

Abstract

Described herein is an effective and practical modular flow design for the meta-selective C-H arylation of anilines. The design consists of four continuous-flow modules (i.e., diaryliodonium salt synthesis, meta-selective C-H arylation, inline copper extraction, and aniline deprotection) which can be operated either individually or consecutively to provide direct access to meta-arylated anilines. With a total residence time of 1 hour, the desired product could be obtained in high yield and excellent purity without the need for column chromatography, and the residual copper content meets the standards for parenterally administered pharmaceutical substances.

Original languageEnglish
Pages (from-to)7161-7165
Number of pages5
JournalAngewandte Chemie - International Edition
Volume56
Issue number25
DOIs
Publication statusPublished - 12 Jun 2017

Keywords

  • C−H activation
  • arylation
  • copper
  • flow chemistry
  • hypervalent compounds

Fingerprint Dive into the research topics of 'A modular flow design for the meta-selective C-H arylation of anilines'. Together they form a unique fingerprint.

  • Cite this