A model for arterial adaptation combining microstructural collagen remodeling and 3D tissue growth

Research output: Book/ReportReportAcademic

25 Citations (Scopus)
63 Downloads (Pure)

Abstract

Long-term adaptation of soft tissues is realized through growth and remodeling (G&R). Mathematical models are powerful tools in testing hypotheses on G&R and supporting the design and interpretation of experiments. Most theoretical G&R studies concentrate on description of either growth or remodeling. Our model combines concepts of remodeling of collagen recruitment stretch and orientation suggested by other authors with a novel model of general 3D growth. We translate a growth-induced volume change into a change in shape due to the interaction of the growing tissue with its environment. Our G&R model is implemented in a finite element package in 3D, but applied to two rotationally symmetric cases, i.e. the adaptation towards the homeostatic state of the human aorta and the development of a fusiform aneurysm. Starting from a guessed non-homeostatic state the model is able to reproduce a homeostatic state of an artery with realistic parameters. We investigate the sensitivity of this state to settings of initial pa- rameters. In addition, we simulate G&R of a fusiform aneurysm, initiated by a localized degradation of the matrix of the healthy artery. The aneurysm stabilizes in size soon after the degradation stops.
Original languageEnglish
Place of PublicationEindhoven
PublisherTechnische Universiteit Eindhoven
Number of pages27
Publication statusPublished - 2010

Publication series

NameCASA-report
Volume1018
ISSN (Print)0926-4507

Fingerprint

collagens
arteries
aorta
mathematical models
degradation
sensitivity
matrices
interactions

Cite this

Machyshyn, I., Bovendeerd, P. H. M., Ven, van de, A. A. F., Rongen, P. M. J., & Vosse, van de, F. N. (2010). A model for arterial adaptation combining microstructural collagen remodeling and 3D tissue growth. (CASA-report; Vol. 1018). Eindhoven: Technische Universiteit Eindhoven.
@book{78f10a808d5c40cda32974d589efedf6,
title = "A model for arterial adaptation combining microstructural collagen remodeling and 3D tissue growth",
abstract = "Long-term adaptation of soft tissues is realized through growth and remodeling (G&R). Mathematical models are powerful tools in testing hypotheses on G&R and supporting the design and interpretation of experiments. Most theoretical G&R studies concentrate on description of either growth or remodeling. Our model combines concepts of remodeling of collagen recruitment stretch and orientation suggested by other authors with a novel model of general 3D growth. We translate a growth-induced volume change into a change in shape due to the interaction of the growing tissue with its environment. Our G&R model is implemented in a finite element package in 3D, but applied to two rotationally symmetric cases, i.e. the adaptation towards the homeostatic state of the human aorta and the development of a fusiform aneurysm. Starting from a guessed non-homeostatic state the model is able to reproduce a homeostatic state of an artery with realistic parameters. We investigate the sensitivity of this state to settings of initial pa- rameters. In addition, we simulate G&R of a fusiform aneurysm, initiated by a localized degradation of the matrix of the healthy artery. The aneurysm stabilizes in size soon after the degradation stops.",
author = "I. Machyshyn and P.H.M. Bovendeerd and {Ven, van de}, A.A.F. and P.M.J. Rongen and {Vosse, van de}, F.N.",
year = "2010",
language = "English",
series = "CASA-report",
publisher = "Technische Universiteit Eindhoven",

}

Machyshyn, I, Bovendeerd, PHM, Ven, van de, AAF, Rongen, PMJ & Vosse, van de, FN 2010, A model for arterial adaptation combining microstructural collagen remodeling and 3D tissue growth. CASA-report, vol. 1018, Technische Universiteit Eindhoven, Eindhoven.

A model for arterial adaptation combining microstructural collagen remodeling and 3D tissue growth. / Machyshyn, I.; Bovendeerd, P.H.M.; Ven, van de, A.A.F.; Rongen, P.M.J.; Vosse, van de, F.N.

Eindhoven : Technische Universiteit Eindhoven, 2010. 27 p. (CASA-report; Vol. 1018).

Research output: Book/ReportReportAcademic

TY - BOOK

T1 - A model for arterial adaptation combining microstructural collagen remodeling and 3D tissue growth

AU - Machyshyn, I.

AU - Bovendeerd, P.H.M.

AU - Ven, van de, A.A.F.

AU - Rongen, P.M.J.

AU - Vosse, van de, F.N.

PY - 2010

Y1 - 2010

N2 - Long-term adaptation of soft tissues is realized through growth and remodeling (G&R). Mathematical models are powerful tools in testing hypotheses on G&R and supporting the design and interpretation of experiments. Most theoretical G&R studies concentrate on description of either growth or remodeling. Our model combines concepts of remodeling of collagen recruitment stretch and orientation suggested by other authors with a novel model of general 3D growth. We translate a growth-induced volume change into a change in shape due to the interaction of the growing tissue with its environment. Our G&R model is implemented in a finite element package in 3D, but applied to two rotationally symmetric cases, i.e. the adaptation towards the homeostatic state of the human aorta and the development of a fusiform aneurysm. Starting from a guessed non-homeostatic state the model is able to reproduce a homeostatic state of an artery with realistic parameters. We investigate the sensitivity of this state to settings of initial pa- rameters. In addition, we simulate G&R of a fusiform aneurysm, initiated by a localized degradation of the matrix of the healthy artery. The aneurysm stabilizes in size soon after the degradation stops.

AB - Long-term adaptation of soft tissues is realized through growth and remodeling (G&R). Mathematical models are powerful tools in testing hypotheses on G&R and supporting the design and interpretation of experiments. Most theoretical G&R studies concentrate on description of either growth or remodeling. Our model combines concepts of remodeling of collagen recruitment stretch and orientation suggested by other authors with a novel model of general 3D growth. We translate a growth-induced volume change into a change in shape due to the interaction of the growing tissue with its environment. Our G&R model is implemented in a finite element package in 3D, but applied to two rotationally symmetric cases, i.e. the adaptation towards the homeostatic state of the human aorta and the development of a fusiform aneurysm. Starting from a guessed non-homeostatic state the model is able to reproduce a homeostatic state of an artery with realistic parameters. We investigate the sensitivity of this state to settings of initial pa- rameters. In addition, we simulate G&R of a fusiform aneurysm, initiated by a localized degradation of the matrix of the healthy artery. The aneurysm stabilizes in size soon after the degradation stops.

M3 - Report

T3 - CASA-report

BT - A model for arterial adaptation combining microstructural collagen remodeling and 3D tissue growth

PB - Technische Universiteit Eindhoven

CY - Eindhoven

ER -