Abstract
| Original language | English |
|---|---|
| Place of Publication | Eindhoven |
| Publisher | Technische Universiteit Eindhoven |
| Number of pages | 27 |
| Publication status | Published - 2010 |
Publication series
| Name | CASA-report |
|---|---|
| Volume | 1018 |
| ISSN (Print) | 0926-4507 |
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A model for arterial adaptation combining microstructural collagen remodeling and 3D tissue growth. / Machyshyn, I.; Bovendeerd, P.H.M.; Ven, van de, A.A.F.; Rongen, P.M.J.; Vosse, van de, F.N.
Eindhoven : Technische Universiteit Eindhoven, 2010. 27 p. (CASA-report; Vol. 1018).Research output: Book/Report › Report › Academic
TY - BOOK
T1 - A model for arterial adaptation combining microstructural collagen remodeling and 3D tissue growth
AU - Machyshyn, I.
AU - Bovendeerd, P.H.M.
AU - Ven, van de, A.A.F.
AU - Rongen, P.M.J.
AU - Vosse, van de, F.N.
PY - 2010
Y1 - 2010
N2 - Long-term adaptation of soft tissues is realized through growth and remodeling (G&R). Mathematical models are powerful tools in testing hypotheses on G&R and supporting the design and interpretation of experiments. Most theoretical G&R studies concentrate on description of either growth or remodeling. Our model combines concepts of remodeling of collagen recruitment stretch and orientation suggested by other authors with a novel model of general 3D growth. We translate a growth-induced volume change into a change in shape due to the interaction of the growing tissue with its environment. Our G&R model is implemented in a finite element package in 3D, but applied to two rotationally symmetric cases, i.e. the adaptation towards the homeostatic state of the human aorta and the development of a fusiform aneurysm. Starting from a guessed non-homeostatic state the model is able to reproduce a homeostatic state of an artery with realistic parameters. We investigate the sensitivity of this state to settings of initial pa- rameters. In addition, we simulate G&R of a fusiform aneurysm, initiated by a localized degradation of the matrix of the healthy artery. The aneurysm stabilizes in size soon after the degradation stops.
AB - Long-term adaptation of soft tissues is realized through growth and remodeling (G&R). Mathematical models are powerful tools in testing hypotheses on G&R and supporting the design and interpretation of experiments. Most theoretical G&R studies concentrate on description of either growth or remodeling. Our model combines concepts of remodeling of collagen recruitment stretch and orientation suggested by other authors with a novel model of general 3D growth. We translate a growth-induced volume change into a change in shape due to the interaction of the growing tissue with its environment. Our G&R model is implemented in a finite element package in 3D, but applied to two rotationally symmetric cases, i.e. the adaptation towards the homeostatic state of the human aorta and the development of a fusiform aneurysm. Starting from a guessed non-homeostatic state the model is able to reproduce a homeostatic state of an artery with realistic parameters. We investigate the sensitivity of this state to settings of initial pa- rameters. In addition, we simulate G&R of a fusiform aneurysm, initiated by a localized degradation of the matrix of the healthy artery. The aneurysm stabilizes in size soon after the degradation stops.
M3 - Report
T3 - CASA-report
BT - A model for arterial adaptation combining microstructural collagen remodeling and 3D tissue growth
PB - Technische Universiteit Eindhoven
CY - Eindhoven
ER -