A mock circulation model for cardiovascular device evalutation

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Abstract

The aim of this study was to develop an integrated mock circulation system that functions in a physiological manner for testing cardiovascular devices under well-controlled circumstances. In contrast to previously reported mock loops, the model includes a systemic, pulmonary, and coronary circulation, an elaborate heart contraction model, and a realistic heart rate control model. The behavior of the presented system was tested in response to changes in left ventricular contractile states, loading conditions, and heart rate. For validation purposes, generated hemodynamic parameters and responses were compared to literature. The model was implemented in a servo-motor driven mock loop, together with a relatively simple lead-lag controller. The pressure and flow signals measured closely mimicked human pressure under both physiological and pathological conditions. In addition, the system's response to changes in preload, afterload, and heart rate indicate a proper implementation of the incorporated feedback mechanisms (frequency and cardiac function control). Therefore, the presented mock circulation allows for generic in vitro testing of cardiovascular devices under well-controlled circumstances.
Original languageEnglish
Pages (from-to)687-702
Number of pages16
JournalPhysiological Measurement
Volume35
Issue number4
DOIs
Publication statusPublished - 2014

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Cardiovascular Models
Heart Rate
Equipment and Supplies
Pressure
Coronary Circulation
Pulmonary Circulation
Hemodynamics
Testing
Lead
Feedback
Controllers

Cite this

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title = "A mock circulation model for cardiovascular device evalutation",
abstract = "The aim of this study was to develop an integrated mock circulation system that functions in a physiological manner for testing cardiovascular devices under well-controlled circumstances. In contrast to previously reported mock loops, the model includes a systemic, pulmonary, and coronary circulation, an elaborate heart contraction model, and a realistic heart rate control model. The behavior of the presented system was tested in response to changes in left ventricular contractile states, loading conditions, and heart rate. For validation purposes, generated hemodynamic parameters and responses were compared to literature. The model was implemented in a servo-motor driven mock loop, together with a relatively simple lead-lag controller. The pressure and flow signals measured closely mimicked human pressure under both physiological and pathological conditions. In addition, the system's response to changes in preload, afterload, and heart rate indicate a proper implementation of the incorporated feedback mechanisms (frequency and cardiac function control). Therefore, the presented mock circulation allows for generic in vitro testing of cardiovascular devices under well-controlled circumstances.",
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A mock circulation model for cardiovascular device evalutation. / Schampaert, S.; Pennings, K.A.M.A.; Molengraft, van de, M.J.G.; Pijls, N.H.J.; Vosse, van de, F.N.; Rutten, M.C.M.

In: Physiological Measurement, Vol. 35, No. 4, 2014, p. 687-702.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Schampaert, S.

AU - Pennings, K.A.M.A.

AU - Molengraft, van de, M.J.G.

AU - Pijls, N.H.J.

AU - Vosse, van de, F.N.

AU - Rutten, M.C.M.

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AB - The aim of this study was to develop an integrated mock circulation system that functions in a physiological manner for testing cardiovascular devices under well-controlled circumstances. In contrast to previously reported mock loops, the model includes a systemic, pulmonary, and coronary circulation, an elaborate heart contraction model, and a realistic heart rate control model. The behavior of the presented system was tested in response to changes in left ventricular contractile states, loading conditions, and heart rate. For validation purposes, generated hemodynamic parameters and responses were compared to literature. The model was implemented in a servo-motor driven mock loop, together with a relatively simple lead-lag controller. The pressure and flow signals measured closely mimicked human pressure under both physiological and pathological conditions. In addition, the system's response to changes in preload, afterload, and heart rate indicate a proper implementation of the incorporated feedback mechanisms (frequency and cardiac function control). Therefore, the presented mock circulation allows for generic in vitro testing of cardiovascular devices under well-controlled circumstances.

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