A method to increase the pulsatility in hemodynamic variables in an LVAD supported human circulation system

S. Bozkurt, K.A.M.A. Pennings, S. Schampaert, F.N. Vosse, van de, M.C.M. Rutten

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

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Abstract

Left Ventricular Assist Devices (LVADs) generally operate at a constant speed in the human body. This causes a decrease in the pulsatility of hemodynamic variables. To increase the pulsatility a stepwise change was applied to the LVAD operating speed over a cardiac cycle. To do this, a numerical cardiovascular system model and a pump model were used. The model was developed by considering the static characteristics of the MicroMed DeBakey LVAD. First, the simulations were performed at constant operating speeds, 8500 rpm, 9500 rpm and 10500 rpm. Pulsatility indexes were calculated for left ventricular (LV) pressure, aortic pressure, LV volume and LVAD flow. Cardiac output (CO) was calculated at constant operating speed and these values used for comparing the pulsatility indexes with stepwise and constant operating speeds. The LVAD was operated at two different constant speeds in the stepwise operating speed simulations. Low and high operating speeds were adjusted so as to obtain the same cardiac output values with the constant operating speed simulations. The operating speeds in the simulations were 7800-11250 rpm, 9300-11250 rpm and 10300-11250 rpm. The same cardiac output values were obtained with an increase in the pulsatility of the hemodynamic variables without significant changes in their shapes except the LVAD flow. The obtained results show that it is possible to obtain more physiological results by applying a stepwise change to LVAD operating speed over a cardiac cycle.
Original languageEnglish
Title of host publicationProceedings of the International Conference on Advancements of Medicine and Health Care through Technology, 29-08-2011-02-09-2011, Cluj-Napoca, Romania
EditorsS. Vlad, R.V. Ciupa
Place of PublicationBerlin
PublisherSpringer
Pages328-331
ISBN (Print)978-3-642-22586-4
DOIs
Publication statusPublished - 2011
Eventconference; International Conference on Advancements of Medicine and Healthe Care through Technology; 2011-08-29; 2011-09-02 -
Duration: 29 Aug 20112 Sep 2011

Publication series

NameIFMBE Proceedings
Volume36

Conference

Conferenceconference; International Conference on Advancements of Medicine and Healthe Care through Technology; 2011-08-29; 2011-09-02
Period29/08/112/09/11
OtherInternational Conference on Advancements of Medicine and Healthe Care through Technology

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Left ventricular assist devices
Hemodynamics
Cardiovascular system

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Bozkurt, S., Pennings, K. A. M. A., Schampaert, S., Vosse, van de, F. N., & Rutten, M. C. M. (2011). A method to increase the pulsatility in hemodynamic variables in an LVAD supported human circulation system. In S. Vlad, & R. V. Ciupa (Eds.), Proceedings of the International Conference on Advancements of Medicine and Health Care through Technology, 29-08-2011-02-09-2011, Cluj-Napoca, Romania (pp. 328-331). (IFMBE Proceedings; Vol. 36). Berlin: Springer. https://doi.org/10.1007/978-3-642-22586-4
Bozkurt, S. ; Pennings, K.A.M.A. ; Schampaert, S. ; Vosse, van de, F.N. ; Rutten, M.C.M. / A method to increase the pulsatility in hemodynamic variables in an LVAD supported human circulation system. Proceedings of the International Conference on Advancements of Medicine and Health Care through Technology, 29-08-2011-02-09-2011, Cluj-Napoca, Romania. editor / S. Vlad ; R.V. Ciupa. Berlin : Springer, 2011. pp. 328-331 (IFMBE Proceedings).
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abstract = "Left Ventricular Assist Devices (LVADs) generally operate at a constant speed in the human body. This causes a decrease in the pulsatility of hemodynamic variables. To increase the pulsatility a stepwise change was applied to the LVAD operating speed over a cardiac cycle. To do this, a numerical cardiovascular system model and a pump model were used. The model was developed by considering the static characteristics of the MicroMed DeBakey LVAD. First, the simulations were performed at constant operating speeds, 8500 rpm, 9500 rpm and 10500 rpm. Pulsatility indexes were calculated for left ventricular (LV) pressure, aortic pressure, LV volume and LVAD flow. Cardiac output (CO) was calculated at constant operating speed and these values used for comparing the pulsatility indexes with stepwise and constant operating speeds. The LVAD was operated at two different constant speeds in the stepwise operating speed simulations. Low and high operating speeds were adjusted so as to obtain the same cardiac output values with the constant operating speed simulations. The operating speeds in the simulations were 7800-11250 rpm, 9300-11250 rpm and 10300-11250 rpm. The same cardiac output values were obtained with an increase in the pulsatility of the hemodynamic variables without significant changes in their shapes except the LVAD flow. The obtained results show that it is possible to obtain more physiological results by applying a stepwise change to LVAD operating speed over a cardiac cycle.",
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Bozkurt, S, Pennings, KAMA, Schampaert, S, Vosse, van de, FN & Rutten, MCM 2011, A method to increase the pulsatility in hemodynamic variables in an LVAD supported human circulation system. in S Vlad & RV Ciupa (eds), Proceedings of the International Conference on Advancements of Medicine and Health Care through Technology, 29-08-2011-02-09-2011, Cluj-Napoca, Romania. IFMBE Proceedings, vol. 36, Springer, Berlin, pp. 328-331, conference; International Conference on Advancements of Medicine and Healthe Care through Technology; 2011-08-29; 2011-09-02, 29/08/11. https://doi.org/10.1007/978-3-642-22586-4

A method to increase the pulsatility in hemodynamic variables in an LVAD supported human circulation system. / Bozkurt, S.; Pennings, K.A.M.A.; Schampaert, S.; Vosse, van de, F.N.; Rutten, M.C.M.

Proceedings of the International Conference on Advancements of Medicine and Health Care through Technology, 29-08-2011-02-09-2011, Cluj-Napoca, Romania. ed. / S. Vlad; R.V. Ciupa. Berlin : Springer, 2011. p. 328-331 (IFMBE Proceedings; Vol. 36).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

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T1 - A method to increase the pulsatility in hemodynamic variables in an LVAD supported human circulation system

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N2 - Left Ventricular Assist Devices (LVADs) generally operate at a constant speed in the human body. This causes a decrease in the pulsatility of hemodynamic variables. To increase the pulsatility a stepwise change was applied to the LVAD operating speed over a cardiac cycle. To do this, a numerical cardiovascular system model and a pump model were used. The model was developed by considering the static characteristics of the MicroMed DeBakey LVAD. First, the simulations were performed at constant operating speeds, 8500 rpm, 9500 rpm and 10500 rpm. Pulsatility indexes were calculated for left ventricular (LV) pressure, aortic pressure, LV volume and LVAD flow. Cardiac output (CO) was calculated at constant operating speed and these values used for comparing the pulsatility indexes with stepwise and constant operating speeds. The LVAD was operated at two different constant speeds in the stepwise operating speed simulations. Low and high operating speeds were adjusted so as to obtain the same cardiac output values with the constant operating speed simulations. The operating speeds in the simulations were 7800-11250 rpm, 9300-11250 rpm and 10300-11250 rpm. The same cardiac output values were obtained with an increase in the pulsatility of the hemodynamic variables without significant changes in their shapes except the LVAD flow. The obtained results show that it is possible to obtain more physiological results by applying a stepwise change to LVAD operating speed over a cardiac cycle.

AB - Left Ventricular Assist Devices (LVADs) generally operate at a constant speed in the human body. This causes a decrease in the pulsatility of hemodynamic variables. To increase the pulsatility a stepwise change was applied to the LVAD operating speed over a cardiac cycle. To do this, a numerical cardiovascular system model and a pump model were used. The model was developed by considering the static characteristics of the MicroMed DeBakey LVAD. First, the simulations were performed at constant operating speeds, 8500 rpm, 9500 rpm and 10500 rpm. Pulsatility indexes were calculated for left ventricular (LV) pressure, aortic pressure, LV volume and LVAD flow. Cardiac output (CO) was calculated at constant operating speed and these values used for comparing the pulsatility indexes with stepwise and constant operating speeds. The LVAD was operated at two different constant speeds in the stepwise operating speed simulations. Low and high operating speeds were adjusted so as to obtain the same cardiac output values with the constant operating speed simulations. The operating speeds in the simulations were 7800-11250 rpm, 9300-11250 rpm and 10300-11250 rpm. The same cardiac output values were obtained with an increase in the pulsatility of the hemodynamic variables without significant changes in their shapes except the LVAD flow. The obtained results show that it is possible to obtain more physiological results by applying a stepwise change to LVAD operating speed over a cardiac cycle.

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SN - 978-3-642-22586-4

T3 - IFMBE Proceedings

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BT - Proceedings of the International Conference on Advancements of Medicine and Health Care through Technology, 29-08-2011-02-09-2011, Cluj-Napoca, Romania

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Bozkurt S, Pennings KAMA, Schampaert S, Vosse, van de FN, Rutten MCM. A method to increase the pulsatility in hemodynamic variables in an LVAD supported human circulation system. In Vlad S, Ciupa RV, editors, Proceedings of the International Conference on Advancements of Medicine and Health Care through Technology, 29-08-2011-02-09-2011, Cluj-Napoca, Romania. Berlin: Springer. 2011. p. 328-331. (IFMBE Proceedings). https://doi.org/10.1007/978-3-642-22586-4