A membrane-anchored aptamer sensor for probing IFNγ secretion by single cells

L. Qiu; F. Wimmers; J. Weiden; H.A. Heus; J. Tel; C.G. Figdor

doi:10.1039/c7cc03576d

A membrane-anchored aptamer sensor for probing IFNγ secretion by single cells

L. Qiu, F. Wimmers, J. Weiden, H.A. Heus, J. Tel, C.G. Figdor

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Abstract

Insight into the behavior of individual immune cells, in particular cytokine secretion, will contribute to a more fundamental understanding of the immune system. In this work, we have developed a cell membrane-anchored sensor for the detection of cytokines secreted by single cells using a combination of aptamer-based sensors and droplet microfluidics.

Original language	English
Pages (from-to)	8066-8069
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	57
DOIs	https://doi.org/10.1039/c7cc03576d
Publication status	Published - 13 Jul 2017

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title = "A membrane-anchored aptamer sensor for probing IFNγ secretion by single cells",

abstract = "Insight into the behavior of individual immune cells, in particular cytokine secretion, will contribute to a more fundamental understanding of the immune system. In this work, we have developed a cell membrane-anchored sensor for the detection of cytokines secreted by single cells using a combination of aptamer-based sensors and droplet microfluidics.",

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AU - Wimmers, F.

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AU - Tel, J.

AU - Figdor, C.G.

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AB - Insight into the behavior of individual immune cells, in particular cytokine secretion, will contribute to a more fundamental understanding of the immune system. In this work, we have developed a cell membrane-anchored sensor for the detection of cytokines secreted by single cells using a combination of aptamer-based sensors and droplet microfluidics.

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A membrane-anchored aptamer sensor for probing IFNγ secretion by single cells

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