A l-glutamate-responsive delivery system based on enzyme-controlled self-immolative arylboronate-gated nanoparticles

Tania M. Godoy-Reyes, Antoni Llopis-Lorente, Alba García-Fernández, Pablo Gaviña, Ana M. Costero (Corresponding author), Reynaldo Villalonga, Félix Sancenón, Ramón Martínez-Máñez (Corresponding author)

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)
1 Downloads (Pure)

Abstract

We report herein a l-glutamate (l-Glu)-responsive delivery system. It consists of Janus Au-mesoporous silica (MS) nanoparticles functionalized with l-glutamate oxidase on the Au face and with self-immolative arylboronate derivatives as caps on the MS face. The MS face is additionally loaded with a cargo. The delivery paradigm is based on the recognition of l-Glu by the enzyme and the subsequent formation of H2O2, which induces the cleavage of the self-immolative gate and the uncapping of the pores. Given the importance of l-Glu as a key neurotransmitter, we hope that these findings will help in designing new therapeutic strategies for nervous system diseases.

Original languageEnglish
Pages (from-to)1058-1063
Number of pages6
JournalOrganic Chemistry Frontiers
Volume6
Issue number7
DOIs
Publication statusPublished - 7 Apr 2019
Externally publishedYes

Fingerprint Dive into the research topics of 'A l-glutamate-responsive delivery system based on enzyme-controlled self-immolative arylboronate-gated nanoparticles'. Together they form a unique fingerprint.

Cite this