A l-glutamate-responsive delivery system based on enzyme-controlled self-immolative arylboronate-gated nanoparticles

Tania M. Godoy-Reyes; Antoni Llopis-Lorente; Alba García-Fernández; Pablo Gaviña; Ana M. Costero; Reynaldo Villalonga; Félix Sancenón; Ramón Martínez-Máñez

doi:10.1039/c9qo00093c

A l-glutamate-responsive delivery system based on enzyme-controlled self-immolative arylboronate-gated nanoparticles

Tania M. Godoy-Reyes, Antoni Llopis-Lorente, Alba García-Fernández, Pablo Gaviña, Ana M. Costero (Corresponding author), Reynaldo Villalonga, Félix Sancenón, Ramón Martínez-Máñez (Corresponding author)

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Abstract

We report herein a l-glutamate (l-Glu)-responsive delivery system. It consists of Janus Au-mesoporous silica (MS) nanoparticles functionalized with l-glutamate oxidase on the Au face and with self-immolative arylboronate derivatives as caps on the MS face. The MS face is additionally loaded with a cargo. The delivery paradigm is based on the recognition of l-Glu by the enzyme and the subsequent formation of H₂O₂, which induces the cleavage of the self-immolative gate and the uncapping of the pores. Given the importance of l-Glu as a key neurotransmitter, we hope that these findings will help in designing new therapeutic strategies for nervous system diseases.

Original language	English
Pages (from-to)	1058-1063
Number of pages	6
Journal	Organic Chemistry Frontiers
Volume	6
Issue number	7
DOIs	https://doi.org/10.1039/c9qo00093c
Publication status	Published - 7 Apr 2019
Externally published	Yes

Funding

T. Godoy-Reyes is grateful to Generalitat Valenciana for her Santiago Grisolía fellowship. A. Llopis-Lorente thanks “La Caixa” Foundation for his PhD grant. A. García-Fernández is grateful to the Spanish Government for her FPU fellowship. The authors gratefully acknowledge the financial support from the Spanish Government (Projects MAT2015-64139-C4-1-R, MAT2015-64139-C4-4-R and AGL2015-70235-C2-2-R) and the Generalitat Valenciana (Project PROMETEO2018/024).

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title = "A l-glutamate-responsive delivery system based on enzyme-controlled self-immolative arylboronate-gated nanoparticles",

abstract = "We report herein a l-glutamate (l-Glu)-responsive delivery system. It consists of Janus Au-mesoporous silica (MS) nanoparticles functionalized with l-glutamate oxidase on the Au face and with self-immolative arylboronate derivatives as caps on the MS face. The MS face is additionally loaded with a cargo. The delivery paradigm is based on the recognition of l-Glu by the enzyme and the subsequent formation of H2O2, which induces the cleavage of the self-immolative gate and the uncapping of the pores. Given the importance of l-Glu as a key neurotransmitter, we hope that these findings will help in designing new therapeutic strategies for nervous system diseases.",

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AU - Godoy-Reyes, Tania M.

AU - Llopis-Lorente, Antoni

AU - García-Fernández, Alba

AU - Gaviña, Pablo

AU - Costero, Ana M.

AU - Villalonga, Reynaldo

AU - Sancenón, Félix

AU - Martínez-Máñez, Ramón

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AB - We report herein a l-glutamate (l-Glu)-responsive delivery system. It consists of Janus Au-mesoporous silica (MS) nanoparticles functionalized with l-glutamate oxidase on the Au face and with self-immolative arylboronate derivatives as caps on the MS face. The MS face is additionally loaded with a cargo. The delivery paradigm is based on the recognition of l-Glu by the enzyme and the subsequent formation of H2O2, which induces the cleavage of the self-immolative gate and the uncapping of the pores. Given the importance of l-Glu as a key neurotransmitter, we hope that these findings will help in designing new therapeutic strategies for nervous system diseases.

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A l-glutamate-responsive delivery system based on enzyme-controlled self-immolative arylboronate-gated nanoparticles

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