A High-throughput Microfluidic Rare Cell Enrichment System Based on Dielectrophoresis and Filtering

Gurhan Ozkayar, Yagmur Demircan Yalçin, Ebru Ozgur, Ufuk Gunduz, Haluk Kulah

Research output: Contribution to journalConference articleAcademicpeer-review

Abstract

In this study, a MEMS-based microfluidic device combining DEP-based cell manipulation with size-based filtration for the enrichment of CTCs from blood with high-throughput was developed. Positive-DEP (pDEP) force and the hydrodynamic force have been used to fine-tune the cell movement over the planar electrodes (sliding) at a high flow rate (30 μl/min). While smaller sized RBCs passed through the gaps and were directed to the waste channels, cancer cells (K562 cells) were filtered and directed to the cancer cell outlet. A cell enrichment factor and depletion rate of RBCs were calculated as 1.45 and 60%, respectively.
Original languageEnglish
Pages (from-to)177-178
Number of pages2
JournalProcedia Technology
Volume27
DOIs
Publication statusPublished - 2017
Externally publishedYes

Bibliographical note

Part of special issue: Biosensors 2016

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