A fully automated continuous-flow platform for fluorescence quenching studies and stern-volmer analysis

Koen P.L. Kuijpers, Cecilia Bottecchia, Dario Cambié, Koen Drummen, Niels J. König, Timothy Noël

Research output: Contribution to journalArticleAcademicpeer-review

26 Citations (Scopus)
109 Downloads (Pure)

Abstract

Herein, we report the first fully automated continuous-flow platform for fluorescence quenching studies and Stern-Volmer analysis. All the components of the platform were automated and controlled by a self-written Python script. A user-friendly software allows even inexperienced operators to perform automated screening of novel quenchers or Stern-Volmer analysis, thus accelerating and facilitating both reaction discovery and mechanistic studies. The operational simplicity of our system affords a time and labor reduction over batch methods while increasing the accuracy and reproducibility of the data produced. Finally, the applicability of our platform is elucidated through relevant case studies.

Original languageEnglish
Pages (from-to)11278-11282
Number of pages5
JournalAngewandte Chemie - International Edition
Volume57
Issue number35
DOIs
Publication statusPublished - 27 Aug 2018

Keywords

  • Automation
  • Continuous flow
  • Fluorescence quenching experiments
  • Photoredox catalysis
  • Stern-Volmer
  • continuous flow
  • automation
  • fluorescence quenching experiments
  • Stern–Volmer
  • photoredox catalysis

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