A facile strategy to prevent trifluoroacetylation of N-terminal proline peptides

C. Haase, M.F. Burton, S.M. Agten, L. Brunsveld

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)
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Abstract

Unwanted trifluoroacetylation occurred at the N-terminus of prolinyl peptides during detachment from the solid phase. This was observed when the N-a-Fmoc protecting group had been removed prior to the final TFA treatment. Subtly changing the SPPS protocol and incorporating Boc- in place of the Fmoc-protected proline as the N-terminal building block efficiently suppressed this side reaction.
Original languageEnglish
Pages (from-to)4763-4765
JournalTetrahedron Letters
Volume53
Issue number35
DOIs
Publication statusPublished - 2012

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