A DEP-based lab-on-a-chip system for the detection of multidrug resistance in K562 leukemia cells

Y. Demircan Yalçın; G. Özkayar; E. Özgür; U. Gündüz; H. Külah

doi:10.31438/trf.hh2016.86

A DEP-based lab-on-a-chip system for the detection of multidrug resistance in K562 leukemia cells

Y. Demircan Yalçın, G. Özkayar, E. Özgür, U. Gündüz, H. Külah

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

1 Citation (Scopus)

Abstract

This study presents a DEP-based lab-on-a-chip (LOC) system for label-free detection of multidrug resistant (MDR) K562 leukemia cells in a cell mixture, consisting of red blood cells (RBCs) and MDR-K562 cells, for the first time in the literature. The system consists of 2 consecutive DEP units, one for the depletion of RBCs and the other for capturing of MDR-K562 cells. RBCs are depleted by 60% in the first unit. In the second unit, MDR-K562 cell detection is performed with 100% selectivity at a flow rate of 10 μl/min and at 20 V_pp in a cell mixture, containing less than 25% MDR-K562 cells.

Original language	English
Title of host publication	2016 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2016
Editors	Mark G. Allen, Tina Lamers
Publisher	Transducer Research Foundation
Pages	316-319
Number of pages	4
ISBN (Electronic)	9781940470023
DOIs	https://doi.org/10.31438/trf.hh2016.86
Publication status	Published - 1 Jan 2016
Externally published	Yes
Event	2016 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2016 - Hilton Head, United States Duration: 5 Jun 2016 → 9 Jun 2016

Conference

Conference	2016 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2016
Country/Territory	United States
City	Hilton Head
Period	5/06/16 → 9/06/16

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10.31438/trf.hh2016.86

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Yalçın, Y. D., Özkayar, G., Özgür, E., Gündüz, U., & Külah, H. (2016). A DEP-based lab-on-a-chip system for the detection of multidrug resistance in K562 leukemia cells. In M. G. Allen, & T. Lamers (Eds.), 2016 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2016 (pp. 316-319). Transducer Research Foundation. https://doi.org/10.31438/trf.hh2016.86

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title = "A DEP-based lab-on-a-chip system for the detection of multidrug resistance in K562 leukemia cells",

abstract = "This study presents a DEP-based lab-on-a-chip (LOC) system for label-free detection of multidrug resistant (MDR) K562 leukemia cells in a cell mixture, consisting of red blood cells (RBCs) and MDR-K562 cells, for the first time in the literature. The system consists of 2 consecutive DEP units, one for the depletion of RBCs and the other for capturing of MDR-K562 cells. RBCs are depleted by 60% in the first unit. In the second unit, MDR-K562 cell detection is performed with 100% selectivity at a flow rate of 10 μl/min and at 20 Vpp in a cell mixture, containing less than 25% MDR-K562 cells.",

author = "Yal{\c c}ın, {Y. Demircan} and G. {\"O}zkayar and E. {\"O}zg{\"u}r and U. G{\"u}nd{\"u}z and H. K{\"u}lah",

year = "2016",

month = jan,

day = "1",

doi = "10.31438/trf.hh2016.86",

language = "English",

pages = "316--319",

editor = "Allen, {Mark G.} and Tina Lamers",

booktitle = "2016 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2016",

publisher = "Transducer Research Foundation",

note = "2016 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2016 ; Conference date: 05-06-2016 Through 09-06-2016",

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Yalçın, YD, Özkayar, G, Özgür, E, Gündüz, U & Külah, H 2016, A DEP-based lab-on-a-chip system for the detection of multidrug resistance in K562 leukemia cells. in MG Allen & T Lamers (eds), 2016 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2016. Transducer Research Foundation, pp. 316-319, 2016 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2016, Hilton Head, United States, 5/06/16. https://doi.org/10.31438/trf.hh2016.86

A DEP-based lab-on-a-chip system for the detection of multidrug resistance in K562 leukemia cells. / Yalçın, Y. Demircan; Özkayar, G.; Özgür, E. et al.
2016 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2016. ed. / Mark G. Allen; Tina Lamers. Transducer Research Foundation, 2016. p. 316-319.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

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AU - Gündüz, U.

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AB - This study presents a DEP-based lab-on-a-chip (LOC) system for label-free detection of multidrug resistant (MDR) K562 leukemia cells in a cell mixture, consisting of red blood cells (RBCs) and MDR-K562 cells, for the first time in the literature. The system consists of 2 consecutive DEP units, one for the depletion of RBCs and the other for capturing of MDR-K562 cells. RBCs are depleted by 60% in the first unit. In the second unit, MDR-K562 cell detection is performed with 100% selectivity at a flow rate of 10 μl/min and at 20 Vpp in a cell mixture, containing less than 25% MDR-K562 cells.

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A DEP-based lab-on-a-chip system for the detection of multidrug resistance in K562 leukemia cells

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