A DEP-based lab-on-a-chip system for the detection of multidrug resistance in K562 leukemia cells

Y. Demircan Yalçın, G. Özkayar, E. Özgür, U. Gündüz, H. Külah

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

1 Citation (Scopus)

Abstract

This study presents a DEP-based lab-on-a-chip (LOC) system for label-free detection of multidrug resistant (MDR) K562 leukemia cells in a cell mixture, consisting of red blood cells (RBCs) and MDR-K562 cells, for the first time in the literature. The system consists of 2 consecutive DEP units, one for the depletion of RBCs and the other for capturing of MDR-K562 cells. RBCs are depleted by 60% in the first unit. In the second unit, MDR-K562 cell detection is performed with 100% selectivity at a flow rate of 10 μl/min and at 20 Vpp in a cell mixture, containing less than 25% MDR-K562 cells.

Original languageEnglish
Title of host publication2016 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2016
EditorsMark G. Allen, Tina Lamers
PublisherTransducer Research Foundation
Pages316-319
Number of pages4
ISBN (Electronic)9781940470023
DOIs
Publication statusPublished - 1 Jan 2016
Externally publishedYes
Event2016 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2016 - Hilton Head, United States
Duration: 5 Jun 20169 Jun 2016

Conference

Conference2016 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2016
Country/TerritoryUnited States
CityHilton Head
Period5/06/169/06/16

Funding

The authors acknowledge The Scientific and Technological Research Council of Turkey (TUBITAK) for the scholarship support for Mrs. Yağmur Demircan Yalçın and for the financial support through project 111E194. *First and second authors have equal contributions on this study.

Fingerprint

Dive into the research topics of 'A DEP-based lab-on-a-chip system for the detection of multidrug resistance in K562 leukemia cells'. Together they form a unique fingerprint.

Cite this