Abstract
This study presents a DEP-based lab-on-a-chip (LOC) system for label-free detection of multidrug resistant (MDR) K562 leukemia cells in a cell mixture, consisting of red blood cells (RBCs) and MDR-K562 cells, for the first time in the literature. The system consists of 2 consecutive DEP units, one for the depletion of RBCs and the other for capturing of MDR-K562 cells. RBCs are depleted by 60% in the first unit. In the second unit, MDR-K562 cell detection is performed with 100% selectivity at a flow rate of 10 μl/min and at 20 Vpp in a cell mixture, containing less than 25% MDR-K562 cells.
| Original language | English |
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| Title of host publication | 2016 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2016 |
| Editors | Mark G. Allen, Tina Lamers |
| Publisher | Transducer Research Foundation |
| Pages | 316-319 |
| Number of pages | 4 |
| ISBN (Electronic) | 9781940470023 |
| DOIs | |
| Publication status | Published - 1 Jan 2016 |
| Externally published | Yes |
| Event | 2016 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2016 - Hilton Head, United States Duration: 5 Jun 2016 → 9 Jun 2016 |
Conference
| Conference | 2016 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2016 |
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| Country/Territory | United States |
| City | Hilton Head |
| Period | 5/06/16 → 9/06/16 |
Funding
The authors acknowledge The Scientific and Technological Research Council of Turkey (TUBITAK) for the scholarship support for Mrs. Yağmur Demircan Yalçın and for the financial support through project 111E194. *First and second authors have equal contributions on this study.