A cross-center smoothness prior for variational Bayesian brain tissue segmentation

Wouter M. Kouw, Silas N. Ørting, Jens Petersen, Kim S. Pedersen, Marleen de Bruijne

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Abstract

Suppose one is faced with the challenge of tissue segmentation in MR images, without annotators at their center to provide labeled training data. One option is to go to another medical center for a trained classifier. Sadly, tissue classifiers do not generalize well across centers due to voxel intensity shifts caused by center-specific acquisition protocols. However, certain aspects of segmentations, such as spatial smoothness, remain relatively consistent and can be learned separately. Here we present a smoothness prior that is fit to segmentations produced at another medical center. This informative prior is presented to an unsupervised Bayesian model. The model clusters the voxel intensities, such that it produces segmentations that are similarly smooth to those of the other medical center. In addition, the unsupervised Bayesian model is extended to a semi-supervised variant, which needs no visual interpretation of clusters into tissues.

Original languageEnglish
Title of host publicationInternational Conference on Information Processing in Medical Imaging
EditorsSiqi Bao, James C. Gee, Paul A. Yushkevich, Albert C.S. Chung
Place of PublicationCham
PublisherSpringer
Pages360-371
Number of pages12
ISBN (Electronic)978-3-030-20351-1
ISBN (Print)978-3-030-20350-4
DOIs
Publication statusPublished - 2019
Externally publishedYes
Event26th International Conference on Information Processing in Medical Imaging, IPMI 2019 - Hong Kong, China
Duration: 2 Jun 20197 Jun 2019

Publication series

NameLecture Notes in Computer Science
Volume11492 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference26th International Conference on Information Processing in Medical Imaging, IPMI 2019
CountryChina
CityHong Kong
Period2/06/197/06/19

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Keywords

  • Bayesian transfer learning
  • Image segmentation
  • Variational inference

Cite this

Kouw, W. M., Ørting, S. N., Petersen, J., Pedersen, K. S., & de Bruijne, M. (2019). A cross-center smoothness prior for variational Bayesian brain tissue segmentation. In S. Bao, J. C. Gee, P. A. Yushkevich, & A. C. S. Chung (Eds.), International Conference on Information Processing in Medical Imaging (pp. 360-371). (Lecture Notes in Computer Science; Vol. 11492 LNCS). Cham: Springer. https://doi.org/10.1007/978-3-030-20351-1_27