A continuum model for platelet plug formation, growth and deformation

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4 Citations (Scopus)


A numerical framework for modelling platelet plug dynamics is presented in this work. It consists of an extension of a biochemical and plug growth model with a solid mechanics model for the plug coupled with a fluid-structure interaction model for the blood flow-plug system. The platelet plug is treated as a neo-Hookean elastic solid, of which the implementation is based on an updated Lagrangian approach. The framework is applied to different haemodynamic configurations coupled with different shear moduli of the plug. Results about plug growth, shape and size, as well as the stress distribution, are shown. Based on the simulations performed, we conclude that the deformability of the platelet plug is essential for its growth.

Original languageEnglish
Pages (from-to)1541-1557
Number of pages17
JournalInternational Journal for Numerical Methods in Biomedical Engineering
Issue number12
Publication statusPublished - 1 Jan 2014


  • Continuum model
  • Fluid-structure interaction
  • Haemodynamics
  • Platelet plug development
  • Platelet plug stress
  • Updated Lagrangian formulation


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