A continuum model for platelet plug formation and growth under flow

F. Storti, F.N. van de Vosse, T.H.S. van Kempen

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

27 Citations (Scopus)

Abstract

When the wall of a blood vessel is damaged, the immediate response of the body to prevent blood loss is the creation of a platelet plug. The process is both chemical (platelets are chemically activated to adhere to the injured wall) and mechanical (platelets are convected by blood flow, which interacts with the forming plug). A continuum model for platelet plug formation and growth is presented in this work, which allows to study the interaction between platelet plug morphology
and local haemodynamics. The framework consists of two parts: a biochemical model [5] and a platelet plug growth model. Results for different cases are shown, together with a comparison between the sole biochemical model and the complete model which includes plug growth. The model opens the way to the development of continuum models for full blod clot formation and growth in physiologically relevant configurations.
Original languageEnglish
Title of host publication3rd International Conference on Computational and Mathematical Biomedical Engineering,
EditorsP. Nithiarasu, R. Löhner, K.M. Liew
PublisherCMBE
Pages85-88
ISBN (Print)978-0-9562914-2-4
Publication statusPublished - 2013
Event3rd International Conference on Computational & Mathematical Biomedical Engineering (CMBE13) - City University of Hong Kong, Hong Kong, China
Duration: 16 Dec 201318 Dec 2013
http://www.compbiomed.net/2013/

Conference

Conference3rd International Conference on Computational & Mathematical Biomedical Engineering (CMBE13)
Abbreviated titleCMBE13
CountryChina
CityHong Kong
Period16/12/1318/12/13
Internet address

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