A continuum model for platelet plug formation and growth under flow

F. Storti; F.N. van de Vosse; T.H.S. van Kempen

A continuum model for platelet plug formation and growth under flow

F. Storti, F.N. van de Vosse, T.H.S. van Kempen

Cardiovascular Biomechanics

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

Abstract

When the wall of a blood vessel is damaged, the immediate response of the body to prevent blood loss is the creation of a platelet plug. The process is both chemical (platelets are chemically activated to adhere to the injured wall) and mechanical (platelets are convected by blood flow, which interacts with the forming plug). A continuum model for platelet plug formation and growth is presented in this work, which allows to study the interaction between platelet plug morphology
and local haemodynamics. The framework consists of two parts: a biochemical model [5] and a platelet plug growth model. Results for different cases are shown, together with a comparison between the sole biochemical model and the complete model which includes plug growth. The model opens the way to the development of continuum models for full blod clot formation and growth in physiologically relevant configurations.

Original language	English
Title of host publication	3rd International Conference on Computational and Mathematical Biomedical Engineering,
Editors	P. Nithiarasu, R. Löhner, K.M. Liew
Publisher	CMBE
Pages	85-88
ISBN (Print)	978-0-9562914-2-4
Publication status	Published - 2013
Event	3rd International Conference on Computational & Mathematical Biomedical Engineering (CMBE13) - City University of Hong Kong, Hong Kong, China Duration: 16 Dec 2013 → 18 Dec 2013 http://www.compbiomed.net/2013/

Conference

Conference	3rd International Conference on Computational & Mathematical Biomedical Engineering (CMBE13)
Abbreviated title	CMBE13
Country/Territory	China
City	Hong Kong
Period	16/12/13 → 18/12/13
Internet address	http://www.compbiomed.net/2013/

Cite this

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title = "A continuum model for platelet plug formation and growth under flow",

abstract = "When the wall of a blood vessel is damaged, the immediate response of the body to prevent blood loss is the creation of a platelet plug. The process is both chemical (platelets are chemically activated to adhere to the injured wall) and mechanical (platelets are convected by blood flow, which interacts with the forming plug). A continuum model for platelet plug formation and growth is presented in this work, which allows to study the interaction between platelet plug morphologyand local haemodynamics. The framework consists of two parts: a biochemical model [5] and a platelet plug growth model. Results for different cases are shown, together with a comparison between the sole biochemical model and the complete model which includes plug growth. The model opens the way to the development of continuum models for full blod clot formation and growth in physiologically relevant configurations.",

author = "F. Storti and {van de Vosse}, F.N. and {van Kempen}, T.H.S.",

year = "2013",

language = "English",

isbn = "978-0-9562914-2-4",

pages = "85--88",

editor = "P. Nithiarasu and R. L{\"o}hner and K.M. Liew",

booktitle = "3rd International Conference on Computational and Mathematical Biomedical Engineering,",

publisher = "CMBE",

note = "3rd International Conference on Computational & Mathematical Biomedical Engineering (CMBE13), CMBE13 ; Conference date: 16-12-2013 Through 18-12-2013",

url = "http://www.compbiomed.net/2013/",

}

Storti, F, van de Vosse, FN & van Kempen, THS 2013, A continuum model for platelet plug formation and growth under flow. in P Nithiarasu, R Löhner & KM Liew (eds), 3rd International Conference on Computational and Mathematical Biomedical Engineering,. CMBE, pp. 85-88, 3rd International Conference on Computational & Mathematical Biomedical Engineering (CMBE13), Hong Kong, China, 16/12/13.

A continuum model for platelet plug formation and growth under flow. / Storti, F.; van de Vosse, F.N.; van Kempen, T.H.S.
3rd International Conference on Computational and Mathematical Biomedical Engineering,. ed. / P. Nithiarasu; R. Löhner; K.M. Liew. CMBE, 2013. p. 85-88.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

TY - GEN

T1 - A continuum model for platelet plug formation and growth under flow

AU - Storti, F.

AU - van de Vosse, F.N.

AU - van Kempen, T.H.S.

PY - 2013

Y1 - 2013

N2 - When the wall of a blood vessel is damaged, the immediate response of the body to prevent blood loss is the creation of a platelet plug. The process is both chemical (platelets are chemically activated to adhere to the injured wall) and mechanical (platelets are convected by blood flow, which interacts with the forming plug). A continuum model for platelet plug formation and growth is presented in this work, which allows to study the interaction between platelet plug morphologyand local haemodynamics. The framework consists of two parts: a biochemical model [5] and a platelet plug growth model. Results for different cases are shown, together with a comparison between the sole biochemical model and the complete model which includes plug growth. The model opens the way to the development of continuum models for full blod clot formation and growth in physiologically relevant configurations.

AB - When the wall of a blood vessel is damaged, the immediate response of the body to prevent blood loss is the creation of a platelet plug. The process is both chemical (platelets are chemically activated to adhere to the injured wall) and mechanical (platelets are convected by blood flow, which interacts with the forming plug). A continuum model for platelet plug formation and growth is presented in this work, which allows to study the interaction between platelet plug morphologyand local haemodynamics. The framework consists of two parts: a biochemical model [5] and a platelet plug growth model. Results for different cases are shown, together with a comparison between the sole biochemical model and the complete model which includes plug growth. The model opens the way to the development of continuum models for full blod clot formation and growth in physiologically relevant configurations.

M3 - Conference contribution

SN - 978-0-9562914-2-4

SP - 85

EP - 88

BT - 3rd International Conference on Computational and Mathematical Biomedical Engineering,

A2 - Nithiarasu, P.

A2 - Löhner, R.

A2 - Liew, K.M.

PB - CMBE

T2 - 3rd International Conference on Computational & Mathematical Biomedical Engineering (CMBE13)

Y2 - 16 December 2013 through 18 December 2013

ER -

A continuum model for platelet plug formation and growth under flow

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