A continuum model for hierarchical fibril assembly

B.S. Lith, van, A. Muntean, C. Storm

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Abstract

Most of the biological polymers that make up our cells and tissues are hierarchically structured. For biopolymers ranging from collagen, to actin, to fibrin and amyloid fibrils this hierarchy provides vitally important versatility. The structural hierarchy must be encoded in the self-assembly process, from the earliest stages onward, in order to produce the appropriate substructures. In this letter, we explore the kinetics of multistage self-assembly processes in a model system which allows comparison to bulk probes such as light scattering. We apply our model to recent turbidimetry data on the self-assembly of collagen fibrils. Our analysis suggests a connection between diffusion-limited aggregation kinetics and fibril growth, supported by slow, power-law growth at very long time scales.
Original languageEnglish
Pages (from-to)68004/1-6
Number of pages6
JournalEPL
Volume106
Issue number6
DOIs
Publication statusPublished - 2014

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