A constitutive modeling interpretation of the relationship between carotid artery stiffness, blood pressure and age in hypertensive subjects

B. Spronck, M.H.G. Heusinkveld, W.P. Donders, A.G.W. Lepper, de, J. Roodt, Op 't, A.A. Kroon, T. Delhaas, K.D. Reesink

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Abstract

Aging has a profound influence on arterial wall structure and function. We have previously reported the relationship between pulse wave velocity, age, and blood pressure in hypertensive subjects. In the present study, we aimed for a quantitative interpretation of the observed changes in wall behavior with age using a constitutive modeling approach. We implemented a model of arterial wall biomechanics and fitted this to the group-averaged pressure-area (P-A) relationship of the "young" subgroup of our study population. Using this model as our take-off point, we assessed which parameters had to be changed to let the model describe the "old" subgroup's P-A relationship. We allowed elastin stiffness and collagen recruitment parameters to vary and adjusted residual stress parameters according to published age-related changes. We required wall stress to be homogeneously distributed over the arterial wall, and assumed wall stress normalization with age by keeping average "old" wall stress at the "young" level. Additionally, we required axial force to remain constant over the cardiac cycle. Our simulations showed a shift in pressure-load bearing from elastin to collagen, caused by a decrease in elastin stiffness and a considerable increase in collagen recruitment. Correspondingly, simulated diameter and wall thickness increased by about 20% and 17%, respectively. The latter compared well with a measured thickness increase of 21%. We conclude that the physiologically realistic changes in constitutive properties we found under physiological constraints with respect to wall stress could well explain the influence of aging in the stiffness-pressure-age pattern observed.
Original languageEnglish
Pages (from-to)H568-H582
JournalAmerican Journal of Physiology : Heart and Circulatory Physiology
Volume308
Issue number6
DOIs
Publication statusPublished - 2015

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Elastin
Carotid Arteries
Collagen
Blood Pressure
Pressure
Pulse Wave Analysis
Weight-Bearing
Biomechanical Phenomena
Population

Cite this

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title = "A constitutive modeling interpretation of the relationship between carotid artery stiffness, blood pressure and age in hypertensive subjects",
abstract = "Aging has a profound influence on arterial wall structure and function. We have previously reported the relationship between pulse wave velocity, age, and blood pressure in hypertensive subjects. In the present study, we aimed for a quantitative interpretation of the observed changes in wall behavior with age using a constitutive modeling approach. We implemented a model of arterial wall biomechanics and fitted this to the group-averaged pressure-area (P-A) relationship of the {"}young{"} subgroup of our study population. Using this model as our take-off point, we assessed which parameters had to be changed to let the model describe the {"}old{"} subgroup's P-A relationship. We allowed elastin stiffness and collagen recruitment parameters to vary and adjusted residual stress parameters according to published age-related changes. We required wall stress to be homogeneously distributed over the arterial wall, and assumed wall stress normalization with age by keeping average {"}old{"} wall stress at the {"}young{"} level. Additionally, we required axial force to remain constant over the cardiac cycle. Our simulations showed a shift in pressure-load bearing from elastin to collagen, caused by a decrease in elastin stiffness and a considerable increase in collagen recruitment. Correspondingly, simulated diameter and wall thickness increased by about 20{\%} and 17{\%}, respectively. The latter compared well with a measured thickness increase of 21{\%}. We conclude that the physiologically realistic changes in constitutive properties we found under physiological constraints with respect to wall stress could well explain the influence of aging in the stiffness-pressure-age pattern observed.",
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A constitutive modeling interpretation of the relationship between carotid artery stiffness, blood pressure and age in hypertensive subjects. / Spronck, B.; Heusinkveld, M.H.G.; Donders, W.P.; Lepper, de, A.G.W.; Roodt, Op 't, J.; Kroon, A.A.; Delhaas, T.; Reesink, K.D.

In: American Journal of Physiology : Heart and Circulatory Physiology, Vol. 308, No. 6, 2015, p. H568-H582.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - A constitutive modeling interpretation of the relationship between carotid artery stiffness, blood pressure and age in hypertensive subjects

AU - Spronck, B.

AU - Heusinkveld, M.H.G.

AU - Donders, W.P.

AU - Lepper, de, A.G.W.

AU - Roodt, Op 't, J.

AU - Kroon, A.A.

AU - Delhaas, T.

AU - Reesink, K.D.

PY - 2015

Y1 - 2015

N2 - Aging has a profound influence on arterial wall structure and function. We have previously reported the relationship between pulse wave velocity, age, and blood pressure in hypertensive subjects. In the present study, we aimed for a quantitative interpretation of the observed changes in wall behavior with age using a constitutive modeling approach. We implemented a model of arterial wall biomechanics and fitted this to the group-averaged pressure-area (P-A) relationship of the "young" subgroup of our study population. Using this model as our take-off point, we assessed which parameters had to be changed to let the model describe the "old" subgroup's P-A relationship. We allowed elastin stiffness and collagen recruitment parameters to vary and adjusted residual stress parameters according to published age-related changes. We required wall stress to be homogeneously distributed over the arterial wall, and assumed wall stress normalization with age by keeping average "old" wall stress at the "young" level. Additionally, we required axial force to remain constant over the cardiac cycle. Our simulations showed a shift in pressure-load bearing from elastin to collagen, caused by a decrease in elastin stiffness and a considerable increase in collagen recruitment. Correspondingly, simulated diameter and wall thickness increased by about 20% and 17%, respectively. The latter compared well with a measured thickness increase of 21%. We conclude that the physiologically realistic changes in constitutive properties we found under physiological constraints with respect to wall stress could well explain the influence of aging in the stiffness-pressure-age pattern observed.

AB - Aging has a profound influence on arterial wall structure and function. We have previously reported the relationship between pulse wave velocity, age, and blood pressure in hypertensive subjects. In the present study, we aimed for a quantitative interpretation of the observed changes in wall behavior with age using a constitutive modeling approach. We implemented a model of arterial wall biomechanics and fitted this to the group-averaged pressure-area (P-A) relationship of the "young" subgroup of our study population. Using this model as our take-off point, we assessed which parameters had to be changed to let the model describe the "old" subgroup's P-A relationship. We allowed elastin stiffness and collagen recruitment parameters to vary and adjusted residual stress parameters according to published age-related changes. We required wall stress to be homogeneously distributed over the arterial wall, and assumed wall stress normalization with age by keeping average "old" wall stress at the "young" level. Additionally, we required axial force to remain constant over the cardiac cycle. Our simulations showed a shift in pressure-load bearing from elastin to collagen, caused by a decrease in elastin stiffness and a considerable increase in collagen recruitment. Correspondingly, simulated diameter and wall thickness increased by about 20% and 17%, respectively. The latter compared well with a measured thickness increase of 21%. We conclude that the physiologically realistic changes in constitutive properties we found under physiological constraints with respect to wall stress could well explain the influence of aging in the stiffness-pressure-age pattern observed.

U2 - 10.1152/ajpheart.00290.2014

DO - 10.1152/ajpheart.00290.2014

M3 - Article

C2 - 25539709

VL - 308

SP - H568-H582

JO - American Journal of Physiology : Heart and Circulatory Physiology

JF - American Journal of Physiology : Heart and Circulatory Physiology

SN - 0363-6135

IS - 6

ER -