A block copolymer for functionalisation of polymersome surfaces

S.F.M. van Dongen; M. Nallani; S. Schoffelen; J.J.L.M. Cornelissen; R.J.M. Nolte; J.C.M. van Hest

doi:10.1002/marc.200700765

A block copolymer for functionalisation of polymersome surfaces

S.F.M. van Dongen, M. Nallani, S. Schoffelen, J.J.L.M. Cornelissen, R.J.M. Nolte, J.C.M. van Hest

Bio-Organic Chemistry

Research output: Contribution to journal › Article › Academic › peer-review

76 Citations (Scopus)

Abstract

A block copolymer was designed to functionalise the surface of polystyrene-based polymersomes via coaggregation. An α,ω- diacetylene-functionalised poly(ethylene glycol) (PEG) was coupled to an azide-terminated polystyrene via a Cu(I)-catalysed cycloaddition to produce a PS-b-PEG polymer with an acetylene at its hydrophilic extremity. Incorporation of this 'anchor' compound in the bilayer of a polymersome places its bio-orthogonal group at the surface of this aggregate. Its accessibility was demonstrated using an azidofunctionalised Candida antarctica Lipase B (CalB), which retained its activity while immobilised on the polymersome.

Original language	English
Pages (from-to)	321-325
Number of pages	5
Journal	Macromolecular Rapid Communications
Volume	29
Issue number	4
DOIs	https://doi.org/10.1002/marc.200700765
Publication status	Published - 18 Feb 2008

Keywords

Diblock copolymers
Enzymes
Polymersomes
Self-organisation
Surface functionalization

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10.1002/marc.200700765

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abstract = "A block copolymer was designed to functionalise the surface of polystyrene-based polymersomes via coaggregation. An α,ω- diacetylene-functionalised poly(ethylene glycol) (PEG) was coupled to an azide-terminated polystyrene via a Cu(I)-catalysed cycloaddition to produce a PS-b-PEG polymer with an acetylene at its hydrophilic extremity. Incorporation of this 'anchor' compound in the bilayer of a polymersome places its bio-orthogonal group at the surface of this aggregate. Its accessibility was demonstrated using an azidofunctionalised Candida antarctica Lipase B (CalB), which retained its activity while immobilised on the polymersome.",

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T1 - A block copolymer for functionalisation of polymersome surfaces

AU - van Dongen, S.F.M.

AU - Nallani, M.

AU - Schoffelen, S.

AU - Cornelissen, J.J.L.M.

AU - Nolte, R.J.M.

AU - van Hest, J.C.M.

PY - 2008/2/18

Y1 - 2008/2/18

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AB - A block copolymer was designed to functionalise the surface of polystyrene-based polymersomes via coaggregation. An α,ω- diacetylene-functionalised poly(ethylene glycol) (PEG) was coupled to an azide-terminated polystyrene via a Cu(I)-catalysed cycloaddition to produce a PS-b-PEG polymer with an acetylene at its hydrophilic extremity. Incorporation of this 'anchor' compound in the bilayer of a polymersome places its bio-orthogonal group at the surface of this aggregate. Its accessibility was demonstrated using an azidofunctionalised Candida antarctica Lipase B (CalB), which retained its activity while immobilised on the polymersome.

KW - Diblock copolymers

KW - Enzymes

KW - Polymersomes

KW - Self-organisation

KW - Surface functionalization

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A block copolymer for functionalisation of polymersome surfaces

Abstract

Keywords

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