A block copolymer for functionalisation of polymersome surfaces

S.F.M. van Dongen; M. Nallani; S. Schoffelen; J.J.L.M. Cornelissen; R.J.M. Nolte; J.C.M. van Hest

doi:10.1002/marc.200700765

A block copolymer for functionalisation of polymersome surfaces

S.F.M. van Dongen, M. Nallani, S. Schoffelen, J.J.L.M. Cornelissen, R.J.M. Nolte, J.C.M. van Hest

Bio-Organic Chemistry

Research output: Contribution to journal › Article › Academic › peer-review

71 Citations (Scopus)

Abstract

A block copolymer was designed to functionalise the surface of polystyrene-based polymersomes via coaggregation. An α,ω- diacetylene-functionalised poly(ethylene glycol) (PEG) was coupled to an azide-terminated polystyrene via a Cu(I)-catalysed cycloaddition to produce a PS-b-PEG polymer with an acetylene at its hydrophilic extremity. Incorporation of this 'anchor' compound in the bilayer of a polymersome places its bio-orthogonal group at the surface of this aggregate. Its accessibility was demonstrated using an azidofunctionalised Candida antarctica Lipase B (CalB), which retained its activity while immobilised on the polymersome.

Original language	English
Pages (from-to)	321-325
Number of pages	5
Journal	Macromolecular Rapid Communications
Volume	29
Issue number	4
DOIs	https://doi.org/10.1002/marc.200700765
Publication status	Published - 18 Feb 2008

Keywords

Diblock copolymers
Enzymes
Polymersomes
Self-organisation
Surface functionalization

Access to Document

10.1002/marc.200700765

Cite this

@article{270de01e279b46dbab21d8f2f3c71b12,

title = "A block copolymer for functionalisation of polymersome surfaces",

abstract = "A block copolymer was designed to functionalise the surface of polystyrene-based polymersomes via coaggregation. An α,ω- diacetylene-functionalised poly(ethylene glycol) (PEG) was coupled to an azide-terminated polystyrene via a Cu(I)-catalysed cycloaddition to produce a PS-b-PEG polymer with an acetylene at its hydrophilic extremity. Incorporation of this 'anchor' compound in the bilayer of a polymersome places its bio-orthogonal group at the surface of this aggregate. Its accessibility was demonstrated using an azidofunctionalised Candida antarctica Lipase B (CalB), which retained its activity while immobilised on the polymersome.",

keywords = "Diblock copolymers, Enzymes, Polymersomes, Self-organisation, Surface functionalization",

author = "{van Dongen}, S.F.M. and M. Nallani and S. Schoffelen and J.J.L.M. Cornelissen and R.J.M. Nolte and {van Hest}, J.C.M.",

year = "2008",

month = feb,

day = "18",

doi = "10.1002/marc.200700765",

language = "English",

volume = "29",

pages = "321--325",

journal = "Macromolecular Rapid Communications",

issn = "1022-1336",

publisher = "Wiley-VCH Verlag",

number = "4",

}

TY - JOUR

T1 - A block copolymer for functionalisation of polymersome surfaces

AU - van Dongen, S.F.M.

AU - Nallani, M.

AU - Schoffelen, S.

AU - Cornelissen, J.J.L.M.

AU - Nolte, R.J.M.

AU - van Hest, J.C.M.

PY - 2008/2/18

Y1 - 2008/2/18

N2 - A block copolymer was designed to functionalise the surface of polystyrene-based polymersomes via coaggregation. An α,ω- diacetylene-functionalised poly(ethylene glycol) (PEG) was coupled to an azide-terminated polystyrene via a Cu(I)-catalysed cycloaddition to produce a PS-b-PEG polymer with an acetylene at its hydrophilic extremity. Incorporation of this 'anchor' compound in the bilayer of a polymersome places its bio-orthogonal group at the surface of this aggregate. Its accessibility was demonstrated using an azidofunctionalised Candida antarctica Lipase B (CalB), which retained its activity while immobilised on the polymersome.

AB - A block copolymer was designed to functionalise the surface of polystyrene-based polymersomes via coaggregation. An α,ω- diacetylene-functionalised poly(ethylene glycol) (PEG) was coupled to an azide-terminated polystyrene via a Cu(I)-catalysed cycloaddition to produce a PS-b-PEG polymer with an acetylene at its hydrophilic extremity. Incorporation of this 'anchor' compound in the bilayer of a polymersome places its bio-orthogonal group at the surface of this aggregate. Its accessibility was demonstrated using an azidofunctionalised Candida antarctica Lipase B (CalB), which retained its activity while immobilised on the polymersome.

KW - Diblock copolymers

KW - Enzymes

KW - Polymersomes

KW - Self-organisation

KW - Surface functionalization

UR - http://www.scopus.com/inward/record.url?scp=45749125891&partnerID=8YFLogxK

U2 - 10.1002/marc.200700765

DO - 10.1002/marc.200700765

M3 - Article

AN - SCOPUS:45749125891

VL - 29

SP - 321

EP - 325

JO - Macromolecular Rapid Communications

JF - Macromolecular Rapid Communications

SN - 1022-1336

IS - 4

ER -

A block copolymer for functionalisation of polymersome surfaces

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this