A block copolymer for functionalisation of polymersome surfaces

S.F.M. van Dongen, M. Nallani, S. Schoffelen, J.J.L.M. Cornelissen, R.J.M. Nolte, J.C.M. van Hest

Research output: Contribution to journalArticleAcademicpeer-review

71 Citations (Scopus)

Abstract

A block copolymer was designed to functionalise the surface of polystyrene-based polymersomes via coaggregation. An α,ω- diacetylene-functionalised poly(ethylene glycol) (PEG) was coupled to an azide-terminated polystyrene via a Cu(I)-catalysed cycloaddition to produce a PS-b-PEG polymer with an acetylene at its hydrophilic extremity. Incorporation of this 'anchor' compound in the bilayer of a polymersome places its bio-orthogonal group at the surface of this aggregate. Its accessibility was demonstrated using an azidofunctionalised Candida antarctica Lipase B (CalB), which retained its activity while immobilised on the polymersome.

Original languageEnglish
Pages (from-to)321-325
Number of pages5
JournalMacromolecular Rapid Communications
Volume29
Issue number4
DOIs
Publication statusPublished - 18 Feb 2008

Keywords

  • Diblock copolymers
  • Enzymes
  • Polymersomes
  • Self-organisation
  • Surface functionalization

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