A 3D active shape model driven by fuzzy inference : application to cardiac CT and MR

H.C. Assen, van, M.G. Danilouchkine, M.S. Dirksen, J.H.C. Reiber, B.P.F. Lelieveldt

Research output: Contribution to journalArticleAcademicpeer-review

74 Citations (Scopus)


Abstract—Manual quantitative analysis of cardiac left ventricular function using Multislice CT and MR is arduous because of the large data volume. In this paper, we present a 3-D active shape model (ASM) for semiautomatic segmentation of cardiac CT and MRvolumes, without the requirement of retraining the underlying statistical shape model. A fuzzy c-means based fuzzy inference system was incorporated into the model. Thus, relative gray-level differences instead of absolute gray values were used for classification of 3-D regions of interest (ROIs), removing the necessity of training different models for different modalities/acquisition protocols. The 3-D ASM was evaluated using 25 CT and 15 MR datasets. Automatically generated contours were compared to expert contours in 100 locations. For CT, 82.4% of epicardial contours and 74.1% of endocardial contours had a maximum error of 5 mm along 95% of the contour arc length. For MR, those numbers were 93.2% (epicardium) and 91.4% (endocardium). Volume regression analysis revealed good linear correlations between manual and semiautomatic volumes, r2 = 0.98. This study shows that the fuzzy inference 3-D ASM is a robust promising instrument for semiautomatic cardiac left ventricle segmentation.Without retraining its statistical shape component, it is applicable to routinely acquired CT and MR studies.
Original languageEnglish
Pages (from-to)595-605
Number of pages11
JournalIEEE Transactions on Information Technology in Biomedicine
Issue number5
Publication statusPublished - 2008


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