3D surface-based registration of ultrasound and histology in prostate cancer imaging

Stefan G Schalk, Arnoud Postema, Tamerlan A Saidov, Libertario Demi, Martijn Smeenge, Jean J M C H de la Rosette, Hessel Wijkstra, Massimo Mischi

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Scopus)
75 Downloads (Pure)


Several transrectal ultrasound (TRUS)-based techniques aiming at accurate localization of prostate cancer are emerging to improve diagnostics or to assist with focal therapy. However, precise validation prior to introduction into clinical practice is required. Histopathology after radical prostatectomy provides an excellent ground truth, but needs accurate registration with imaging. In this work, a 3D, surface-based, elastic registration method was developed to fuse TRUS images with histopathologic results. To maximize the applicability in clinical practice, no auxiliary sensors or dedicated hardware were used for the registration. The mean registration errors, measured in vitro and in vivo, were 1.5±0.2 and 2.1±0.5mm, respectively.

Original languageEnglish
Pages (from-to)29-39
Number of pages11
JournalComputerized Medical Imaging and Graphics
Publication statusPublished - 28 Nov 2015


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