TY - JOUR
T1 - 3D printed poly(lactic acid) scaffolds modified with chitosan and hydroxyapatite for bone repair applications
AU - Nazeer, Muhammad Anwaar
AU - Onder, Ozgun Can
AU - Sevgili, Ilkem
AU - Yilgor, Emel
AU - Kavakli, Ibrahim Halil
AU - Yilgor, Iskender
N1 - Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2020/12
Y1 - 2020/12
N2 - 3D printed poly(lactic acid) (PLA) scaffolds surface modified with chitosan (CS) and hydroxyapatite (HA) to produce a novel bioactive composite scaffold is reported. Excellent mechanical properties of PLA, the bioactivity of CS, and osteogenic characteristics of HA are combined to fabricate composite scaffolds using a simple desktop 3D printer. Scaffolds were characterized through attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy, scanning electron microscopy (SEM), energy dispersive X-ray (EDX) spectroscopy, X-ray diffraction (XRD) and water contact angle measurements before and after modification. Formic acid was used as a solvent to prepare stable CS/HA dispersions and was found to be a suitable solvent for producing PLA/CS/HA composites. Surface properties of modified scaffolds were superior in terms of hydrophilicity and bioactivity, which resulted in enhanced attachment and proliferation of human osteosarcoma cells in vitro compared to the unmodified PLA scaffolds.
AB - 3D printed poly(lactic acid) (PLA) scaffolds surface modified with chitosan (CS) and hydroxyapatite (HA) to produce a novel bioactive composite scaffold is reported. Excellent mechanical properties of PLA, the bioactivity of CS, and osteogenic characteristics of HA are combined to fabricate composite scaffolds using a simple desktop 3D printer. Scaffolds were characterized through attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy, scanning electron microscopy (SEM), energy dispersive X-ray (EDX) spectroscopy, X-ray diffraction (XRD) and water contact angle measurements before and after modification. Formic acid was used as a solvent to prepare stable CS/HA dispersions and was found to be a suitable solvent for producing PLA/CS/HA composites. Surface properties of modified scaffolds were superior in terms of hydrophilicity and bioactivity, which resulted in enhanced attachment and proliferation of human osteosarcoma cells in vitro compared to the unmodified PLA scaffolds.
KW - 3D printing
KW - Bioactive composite scaffolds
KW - Bone tissue engineering
KW - Chitosan
KW - Hydroxyapatite
KW - PLA
UR - http://www.scopus.com/inward/record.url?scp=85089495372&partnerID=8YFLogxK
U2 - 10.1016/j.mtcomm.2020.101515
DO - 10.1016/j.mtcomm.2020.101515
M3 - Article
AN - SCOPUS:85089495372
SN - 2352-4928
VL - 25
JO - Materials Today Communications
JF - Materials Today Communications
M1 - 101515
ER -