3D fusion of intravascular ultrasound and coronary computed tomography for in-vivo wall shear stress analysis : a feasibility study

A.G. Giessen, van der, M. Schaap, F.J.H. Gijsen, H.C. Groen, T. Walsum, van, N.R. Mollet, Jouke Dijkstra, F.N. Vosse, van de, W.J. Niessen, P.J. Feyter, de, A.F.W. Steen, van der, J.J. Wentzel

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Abstract

Wall shear stress, the force per areaacting on the lumen wall due to the blood flow, isan important biomechanical parameter in the localizationand progression of atherosclerosis. To calculateshear stress and relate it to atherosclerosis, a3D description of the lumen and vessel wall isrequired. We present a framework to obtain the 3Dreconstruction of human coronary arteries by thefusion of intravascular ultrasound (IVUS) and coronarycomputed tomography angiography (CT). Weimaged 23 patients with IVUS and CT. The imagesfrom both modalities were registered for 35 arteries,using bifurcations as landmarks. The IVUS imagestogether with IVUS derived lumen and wall contourswere positioned on the 3D centerline, whichwas derived from CT. The resulting 3D lumen andwall contours were transformed to a surface forcalculation of shear stress and plaque thickness. Weapplied variations in selection of landmarks andinvestigated whether these variations influenced therelation between shear stress and plaque thickness.Fusion was successfully achieved in 31 of the 35arteries. The average length of the fused segmentswas 36.4 ± 15.7 mm. The length in IVUS and CTof the fused parts correlated excellently (R2 = 0.98).Both for a mildly diseased and a very diseasedcoronary artery, shear stress was calculated andrelated to plaque thickness. Variations in the selectionof the landmarks for these two arteries did notaffect the relationship between shear stress andplaque thickness. This new framework can thereforesuccessfully be applied for shear stress analysis inhuman coronary arteries.
Original languageEnglish
Pages (from-to)781-796
JournalThe International Journal of Cardiovascular Imaging
Volume26
Issue number7
DOIs
Publication statusPublished - 2010

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Feasibility Studies
Angiography
Arteries
Tomography
Atherosclerosis
Coronary Vessels

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Giessen, van der, A.G. ; Schaap, M. ; Gijsen, F.J.H. ; Groen, H.C. ; Walsum, van, T. ; Mollet, N.R. ; Dijkstra, Jouke ; Vosse, van de, F.N. ; Niessen, W.J. ; Feyter, de, P.J. ; Steen, van der, A.F.W. ; Wentzel, J.J. / 3D fusion of intravascular ultrasound and coronary computed tomography for in-vivo wall shear stress analysis : a feasibility study. In: The International Journal of Cardiovascular Imaging. 2010 ; Vol. 26, No. 7. pp. 781-796.
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title = "3D fusion of intravascular ultrasound and coronary computed tomography for in-vivo wall shear stress analysis : a feasibility study",
abstract = "Wall shear stress, the force per areaacting on the lumen wall due to the blood flow, isan important biomechanical parameter in the localizationand progression of atherosclerosis. To calculateshear stress and relate it to atherosclerosis, a3D description of the lumen and vessel wall isrequired. We present a framework to obtain the 3Dreconstruction of human coronary arteries by thefusion of intravascular ultrasound (IVUS) and coronarycomputed tomography angiography (CT). Weimaged 23 patients with IVUS and CT. The imagesfrom both modalities were registered for 35 arteries,using bifurcations as landmarks. The IVUS imagestogether with IVUS derived lumen and wall contourswere positioned on the 3D centerline, whichwas derived from CT. The resulting 3D lumen andwall contours were transformed to a surface forcalculation of shear stress and plaque thickness. Weapplied variations in selection of landmarks andinvestigated whether these variations influenced therelation between shear stress and plaque thickness.Fusion was successfully achieved in 31 of the 35arteries. The average length of the fused segmentswas 36.4 ± 15.7 mm. The length in IVUS and CTof the fused parts correlated excellently (R2 = 0.98).Both for a mildly diseased and a very diseasedcoronary artery, shear stress was calculated andrelated to plaque thickness. Variations in the selectionof the landmarks for these two arteries did notaffect the relationship between shear stress andplaque thickness. This new framework can thereforesuccessfully be applied for shear stress analysis inhuman coronary arteries.",
author = "{Giessen, van der}, A.G. and M. Schaap and F.J.H. Gijsen and H.C. Groen and {Walsum, van}, T. and N.R. Mollet and Jouke Dijkstra and {Vosse, van de}, F.N. and W.J. Niessen and {Feyter, de}, P.J. and {Steen, van der}, A.F.W. and J.J. Wentzel",
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doi = "10.1007/s10554-009-9546-y",
language = "English",
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Giessen, van der, AG, Schaap, M, Gijsen, FJH, Groen, HC, Walsum, van, T, Mollet, NR, Dijkstra, J, Vosse, van de, FN, Niessen, WJ, Feyter, de, PJ, Steen, van der, AFW & Wentzel, JJ 2010, '3D fusion of intravascular ultrasound and coronary computed tomography for in-vivo wall shear stress analysis : a feasibility study', The International Journal of Cardiovascular Imaging, vol. 26, no. 7, pp. 781-796. https://doi.org/10.1007/s10554-009-9546-y

3D fusion of intravascular ultrasound and coronary computed tomography for in-vivo wall shear stress analysis : a feasibility study. / Giessen, van der, A.G.; Schaap, M.; Gijsen, F.J.H.; Groen, H.C.; Walsum, van, T.; Mollet, N.R.; Dijkstra, Jouke; Vosse, van de, F.N.; Niessen, W.J.; Feyter, de, P.J.; Steen, van der, A.F.W.; Wentzel, J.J.

In: The International Journal of Cardiovascular Imaging, Vol. 26, No. 7, 2010, p. 781-796.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - 3D fusion of intravascular ultrasound and coronary computed tomography for in-vivo wall shear stress analysis : a feasibility study

AU - Giessen, van der, A.G.

AU - Schaap, M.

AU - Gijsen, F.J.H.

AU - Groen, H.C.

AU - Walsum, van, T.

AU - Mollet, N.R.

AU - Dijkstra, Jouke

AU - Vosse, van de, F.N.

AU - Niessen, W.J.

AU - Feyter, de, P.J.

AU - Steen, van der, A.F.W.

AU - Wentzel, J.J.

PY - 2010

Y1 - 2010

N2 - Wall shear stress, the force per areaacting on the lumen wall due to the blood flow, isan important biomechanical parameter in the localizationand progression of atherosclerosis. To calculateshear stress and relate it to atherosclerosis, a3D description of the lumen and vessel wall isrequired. We present a framework to obtain the 3Dreconstruction of human coronary arteries by thefusion of intravascular ultrasound (IVUS) and coronarycomputed tomography angiography (CT). Weimaged 23 patients with IVUS and CT. The imagesfrom both modalities were registered for 35 arteries,using bifurcations as landmarks. The IVUS imagestogether with IVUS derived lumen and wall contourswere positioned on the 3D centerline, whichwas derived from CT. The resulting 3D lumen andwall contours were transformed to a surface forcalculation of shear stress and plaque thickness. Weapplied variations in selection of landmarks andinvestigated whether these variations influenced therelation between shear stress and plaque thickness.Fusion was successfully achieved in 31 of the 35arteries. The average length of the fused segmentswas 36.4 ± 15.7 mm. The length in IVUS and CTof the fused parts correlated excellently (R2 = 0.98).Both for a mildly diseased and a very diseasedcoronary artery, shear stress was calculated andrelated to plaque thickness. Variations in the selectionof the landmarks for these two arteries did notaffect the relationship between shear stress andplaque thickness. This new framework can thereforesuccessfully be applied for shear stress analysis inhuman coronary arteries.

AB - Wall shear stress, the force per areaacting on the lumen wall due to the blood flow, isan important biomechanical parameter in the localizationand progression of atherosclerosis. To calculateshear stress and relate it to atherosclerosis, a3D description of the lumen and vessel wall isrequired. We present a framework to obtain the 3Dreconstruction of human coronary arteries by thefusion of intravascular ultrasound (IVUS) and coronarycomputed tomography angiography (CT). Weimaged 23 patients with IVUS and CT. The imagesfrom both modalities were registered for 35 arteries,using bifurcations as landmarks. The IVUS imagestogether with IVUS derived lumen and wall contourswere positioned on the 3D centerline, whichwas derived from CT. The resulting 3D lumen andwall contours were transformed to a surface forcalculation of shear stress and plaque thickness. Weapplied variations in selection of landmarks andinvestigated whether these variations influenced therelation between shear stress and plaque thickness.Fusion was successfully achieved in 31 of the 35arteries. The average length of the fused segmentswas 36.4 ± 15.7 mm. The length in IVUS and CTof the fused parts correlated excellently (R2 = 0.98).Both for a mildly diseased and a very diseasedcoronary artery, shear stress was calculated andrelated to plaque thickness. Variations in the selectionof the landmarks for these two arteries did notaffect the relationship between shear stress andplaque thickness. This new framework can thereforesuccessfully be applied for shear stress analysis inhuman coronary arteries.

U2 - 10.1007/s10554-009-9546-y

DO - 10.1007/s10554-009-9546-y

M3 - Article

VL - 26

SP - 781

EP - 796

JO - The International Journal of Cardiovascular Imaging

JF - The International Journal of Cardiovascular Imaging

SN - 1569-5794

IS - 7

ER -