3-D quantitative dynamic contrast ultrasound for prostate cancer localization

S.G. Schalk, J. Huang, J. Li, L. Demi, H. Wijkstra, P. Huang, M. Mischi

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)
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To investigate quantitative 3-D dynamic contrast-enhanced ultrasound (DCE-US) and, in particular 3-D contrast-ultrasound dispersion imaging (CUDI), for prostate cancer detection and localization, 43 patients referred for 10-12-core systematic biopsy underwent 3-D DCE-US. For each 3-D DCE-US recording, parametric maps of CUDI-based and perfusion-based parameters were computed. The parametric maps were divided in regions, each corresponding to a biopsy core. The obtained parameters were validated per biopsy location and after combining two or more adjacent regions. For CUDI by correlation (r) and for the wash-in time (WIT), a significant difference in parameter values between benign and malignant biopsy cores was found (p < 0.001). In a per-prostate analysis, sensitivity and specificity were 94% and 50% for r, and 53% and 81% for WIT. Based on these results, it can be concluded that quantitative 3-D DCE-US could aid in localizing prostate cancer. Therefore, we recommend follow-up studies to investigate its value for targeting biopsies.

Original languageEnglish
Pages (from-to)807-814
Number of pages8
JournalUltrasound in Medicine and Biology
Issue number4
Early online date22 Jan 2018
Publication statusPublished - Apr 2018


  • Contrast ultrasound,
  • Dynamic contrast-enhanced ultrasound
  • 3-D ultrasound
  • Prostate cancer imaging
  • Dispersion imaging
  • Quantitative
  • Core needle biopsy
  • Systematic biopsy
  • Contrast ultrasound
  • Prostate/diagnostic imaging
  • Imaging, Three-Dimensional/methods
  • Humans
  • Middle Aged
  • Ultrasonography/methods
  • Male
  • Prostatic Neoplasms/diagnostic imaging
  • Contrast Media
  • Biopsy
  • Sensitivity and Specificity
  • Aged, 80 and over
  • Aged
  • Image Enhancement/methods
  • Evaluation Studies as Topic


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