Abstract
Metastasis, the major cause of cancer related deaths, is a multi-step procedure, influenced by many factors and cues present in the tumor microenvironment. One important but not thoroughly studied factor is hypoxia. In this study, we introduce the design, fabrication and validation of a PDMS chip to study the effect of hypoxia on the migration of cancer cells in 3D. The chip contains a cell culture chamber in which a linear and stable oxygen gradient can be established by an oxygen leaching fluid flowing through a neighboring channel, and enables to observe the migration of cancer cells in 3D.
| Original language | English |
|---|---|
| Title of host publication | MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
| Publisher | Royal Society of Chemistry |
| Pages | 514-515 |
| Number of pages | 2 |
| ISBN (Electronic) | 9781733419048 |
| Publication status | Published - 2022 |
| Event | 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022 - Hybrid, Hangzhou, China Duration: 23 Oct 2022 → 27 Oct 2022 |
Conference
| Conference | 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022 |
|---|---|
| Country/Territory | China |
| City | Hybrid, Hangzhou |
| Period | 23/10/22 → 27/10/22 |
Funding
The authors would like to acknowledge the financial contribution of NWO under the project “The Active Matter of Collective Metastasis (NWO-ENW Groot) ”.
| Funders |
|---|
| Nederlandse Organisatie voor Wetenschappelijk Onderzoek |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- 3D Culturing
- Hypoxia
- Metastasis
- Microfluidic Chip
- Oxygen Gradient
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