14-3-3: A case study in ppi modulation

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Abstract

In recent years, targeting the complex network of protein–protein interactions (PPIs) has been identified as a promising drug-discovery approach to develop new therapeutic strategies. 14-3-3 is a family of eukaryotic conserved regulatory proteins which are of high interest as potential targets for pharmacological intervention in human diseases, such as cancer and neurodegenerative and metabolic disorders. This viewpoint is built on the “hub” nature of the 14-3-3 proteins, binding to several hundred identified partners, consequently implicating them in a multitude of different cellular mechanisms. In this review, we provide an overview of the structural and biological features of 14-3-3 and the modulation of 14-3-3 PPIs for discovering small molecular inhibitors and stabilizers of 14-3-3 PPIs.

Original languageEnglish
Article number1386
Number of pages14
JournalMolecules
Volume23
Issue number6
DOIs
Publication statusPublished - 8 Jun 2018

Keywords

  • 14-3-3 PPIs
  • PPI modulation
  • Small molecules
  • Protein Interaction Maps/physiology
  • Humans
  • Ligands
  • 14-3-3 Proteins/metabolism
  • small molecules

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