1-Phenylcyclohexanemethylamines

E.F. Godefroi

1-Phenylcyclohexanemethylamines

E.F. Godefroi (Inventor)

Chemical Engineering and Chemistry

Research output: Patent › Patent publication

Abstract

1-Phenylcyclohexanemethylamine is alkylated with various agents to give N-alkyl derivs. These products are useful pharmaceutically as analeptic agents. E.g., 0.6 g. Ac2O is added to 5.7 g. 1-phenylcyclohexanemethylamine (I) in 25 ml. C6H6. The mixt. is worked up to give the amide which is mixed with ether and added to 5 g. LiAlH4 in 400 ml. ether. This soln. is refluxed 3 hrs. and worked up. The ether soln. is then treated with HCl in PrOH to give II.HCl, m. 208-9 Deg. Similarly (EtCO)2O with I gives III.HCl, m. 204-5 Deg. Succinic anhydride gives N-(1-phenylcyclohexylmethyl)pyrrolidine-HCl, m. 219-20 Deg. [on SciFinder (R)]

Original language	English
Publication status	Published - 16 May 1967

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title = "1-Phenylcyclohexanemethylamines",

abstract = "1-Phenylcyclohexanemethylamine is alkylated with various agents to give N-alkyl derivs. These products are useful pharmaceutically as analeptic agents. E.g., 0.6 g. Ac2O is added to 5.7 g. 1-phenylcyclohexanemethylamine (I) in 25 ml. C6H6. The mixt. is worked up to give the amide which is mixed with ether and added to 5 g. LiAlH4 in 400 ml. ether. This soln. is refluxed 3 hrs. and worked up. The ether soln. is then treated with HCl in PrOH to give II.HCl, m. 208-9 Deg. Similarly (EtCO)2O with I gives III.HCl, m. 204-5 Deg. Succinic anhydride gives N-(1-phenylcyclohexylmethyl)pyrrolidine-HCl, m. 219-20 Deg. [on SciFinder (R)]",

author = "E.F. Godefroi",

year = "1967",

month = may,

day = "16",

language = "English",

type = "Patent",

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TY - PAT

T1 - 1-Phenylcyclohexanemethylamines

AU - Godefroi, E.F.

PY - 1967/5/16

Y1 - 1967/5/16

N2 - 1-Phenylcyclohexanemethylamine is alkylated with various agents to give N-alkyl derivs. These products are useful pharmaceutically as analeptic agents. E.g., 0.6 g. Ac2O is added to 5.7 g. 1-phenylcyclohexanemethylamine (I) in 25 ml. C6H6. The mixt. is worked up to give the amide which is mixed with ether and added to 5 g. LiAlH4 in 400 ml. ether. This soln. is refluxed 3 hrs. and worked up. The ether soln. is then treated with HCl in PrOH to give II.HCl, m. 208-9 Deg. Similarly (EtCO)2O with I gives III.HCl, m. 204-5 Deg. Succinic anhydride gives N-(1-phenylcyclohexylmethyl)pyrrolidine-HCl, m. 219-20 Deg. [on SciFinder (R)]

AB - 1-Phenylcyclohexanemethylamine is alkylated with various agents to give N-alkyl derivs. These products are useful pharmaceutically as analeptic agents. E.g., 0.6 g. Ac2O is added to 5.7 g. 1-phenylcyclohexanemethylamine (I) in 25 ml. C6H6. The mixt. is worked up to give the amide which is mixed with ether and added to 5 g. LiAlH4 in 400 ml. ether. This soln. is refluxed 3 hrs. and worked up. The ether soln. is then treated with HCl in PrOH to give II.HCl, m. 208-9 Deg. Similarly (EtCO)2O with I gives III.HCl, m. 204-5 Deg. Succinic anhydride gives N-(1-phenylcyclohexylmethyl)pyrrolidine-HCl, m. 219-20 Deg. [on SciFinder (R)]

M3 - Patent publication

ER -

1-Phenylcyclohexanemethylamines

Abstract

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