@article{512fcc21024644c1a4e5bf19fcf3307c,
title = "1-aminoisoquinoline as benzamidine isoster in the design and synthesis of orally active thrombin inhibitors",
abstract = "Replacement of the highly basic benzamidine moiety of NAPAP by the moderately basic 1-aminoisoquinoline moiety resulted in thrombin inhibitors with improved selectivity towards trypsin and enhanced Caco-2 cell permeability.",
author = "J.B.M. Rewinkel and H. Lucas and {Galen, van}, P.J.M. and A.B.J. Noach and {Dinther, van}, T.G. and A.M.M. Rood and A.J.S.M. Jenneboer and {Boeckel, van}, C.A.A.",
year = "1999",
doi = "10.1016/S0960-894X(99)00069-4",
language = "English",
volume = "9",
pages = "685--690",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier",
number = "5",
}