Priming the epileptic brain

Project: Research direct

Project Details


The most prevalent neurological disorder with also immense burden of disease, epilepsy, is in over 30 percent of patients difficult to treat. The ideal treatment regime would give complete control of disease in an early stage, not only for patient well-being, but also to prevent the onset of persistent pathologic epileptic networks in the brain. The first step in treatment is the trial, and error, of multiple anti-epileptic drugs (AEDs), while invasive brain stimulation (BS) techniques with network modulating properties are saved as a last resort. We hypothesize that pharmacotherapeutic treatment of epilepsy can be more successful after “priming” (preparing) the brain using BS as a short-term neuromodulation treatment. The limitation of testing this hypothesis is the invasive aspect of the most used classic vagal nerve stimulation (VNS) treatment for epilepsy, but the recent development of transcutaneous vagal nerve stimulation(tVNS) offered a possibility to combine chemical and electrical modulation in an earlier stage of disease, which is not tested before.

Layman's description

In Prep, we study if brain stimulation can help to reduce or replace pharmacotherapeutic treatment of epilepsy
Effective start/end date1/03/1829/05/22


  • TKI-LS&H