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2024
Does GLP-1 cause post-bariatric hypoglycemia: 'Computer says no'
Pasveer, Y. M., Aydin, Ö., Groen, A. K., Meijnikman, A. S., Nieuwdorp, M., Gerdes, V. E. A. & van Riel, N. A. W. (Corresponding author), Dec 2024, In: Computer Methods and Programs in Biomedicine. 257, 9 p., 108424.Research output: Contribution to journal › Article › Academic › peer-review
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2023
A data-driven computational model for obesity-driven diabetes onset and remission through weight loss
Yildirim, V. (Corresponding author), Sheraton, V. M., Brands, R., Crielaard, L., Quax, R., van Riel, N. A. W., Stronks, K., Nicolaou, M. & Sloot, P. M. A., 17 Nov 2023, In: iScience. 26, 11, 25 p., 108324.Research output: Contribution to journal › Article › Academic › peer-review
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Bariatric surgery improves postprandial VLDL kinetics and restores insulin mediated regulation of hepatic VLDL production
Yildirim, V. (Corresponding author), Ter Horst, K. W., Gilijamse, P. W., van Harskamp, D., Schierbeek, H., Jansen, H., Schimmel, A., Nieuwdorp, M., Groen, A. K., Serlie, M. J., van Riel, N. A. W. & Dallinga-Thie, G. M., 22 Aug 2023, In: JCI Insight. 8, 16, e166905.Research output: Contribution to journal › Article › Academic › peer-review
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2022
A Systems Analysis of Phenotype Heterogeneity in APOE*3Leiden.CETP Mice Induced by Long-Term High-Fat High-Cholesterol Diet Feeding
Paalvast, Y., Zhou, E., Rozendaal, Y. J. W., Wang, Y., Gerding, A., van Dijk, T. H., de Boer, J. F., Rensen, P. C. N., Willems van Dijk, K., Kuivenhoven, J. A., Bakker, B. M., van Riel, N. A. W. & Groen, A. K. (Corresponding author), 21 Nov 2022, In: Nutrients. 14, 22, 15 p., 4936.Research output: Contribution to journal › Article › Academic › peer-review
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2021
Altered bile acid kinetics contribute to postprandial hypoglycaemia after Roux-en-Y gastric bypass surgery
van den Broek, M., de Heide, L. J. M., Sips, F. L. P., Koehorst, M., van Zutphen, T., Emous, M., van Faassen, M., Groen, A. K., van Riel, N. A. W., de Boer, J. F., van Beek, A. P. & Kuipers, F. (Corresponding author), Mar 2021, In: International Journal of Obesity. 45, 3, p. 619-630 12 p.Research output: Contribution to journal › Article › Academic › peer-review
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Metabolic Modeling Combined With Machine Learning Integrates Longitudinal Data and Identifies the Origin of LXR-Induced Hepatic Steatosis
van Riel, N. A. W. (Corresponding author), Tiemann, C. A., Hilbers, P. A. J. & Groen, A. K., 16 Feb 2021, In: Frontiers in Bioengineering and Biotechnology. 8, 18 p., 536957.Research output: Contribution to journal › Article › Academic › peer-review
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2020
Model-based data analysis of individual human postprandial plasma bile acid responses indicates a major role for the gallbladder and intestine
Meessen, E. C. E., Sips, F. L. P., Eggink, H. M., Koehorst, M., Romijn, J. A., Groen, A. K., van Riel, N. A. W. & Soeters, M. R. (Corresponding author), 1 Mar 2020, In: Physiological Reports. 8, 5, 14 p., e14358.Research output: Contribution to journal › Article › Academic › peer-review
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2018
In silico analysis identifies intestinal transit as a key determinant of systemic bile acid metabolism
Sips, F. L. P., Eggink, H. M., Hilbers, P. A. J., Soeters, M. R., Groen, A. K. & van Riel, N. A. W., 8 Jun 2018, In: Frontiers in Physiology. 9, 631.Research output: Contribution to journal › Article › Academic › peer-review
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In vivo and in silico dynamics of the development of Metabolic Syndrome
Rozendaal, Y. J. W., Wang, Y., Paalvast, Y., Tambyrajah, L. L., Li, Z., Willems van Dijk, K., Rensen, P. C. N., Kuivenhoven, J. A., Groen, A. K., Hilbers, P. A. J. & van Riel, N. A. W., 1 Jun 2018, In: PLoS Computational Biology. 14, 6, e1006145.Research output: Contribution to journal › Article › Academic › peer-review
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Model-based analysis of postprandial glycemic response dynamics for different types of food
Rozendaal, Y. J., Maas, A. H., van Pul, C., Cottaar, E. J. E., Haak, H. R., Hilbers, P. A. J. & van Riel, N. A., Jun 2018, In: Clinical Nutrition Experimental. 19, p. 32-45 14 p.Research output: Contribution to journal › Article › Academic › peer-review
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2016
Requirements for multi-level systems pharmacology models to reach end-usage: the case of type 2 diabetes
Nyman, E., Rozendaal, Y. J. W., Helmlinger, G., Hamrén, B., Kjellsson, M. C., Strålfors, P., van Riel, N. A. W., Gennemark, P. & Cedersund, G., 6 Apr 2016, In: Interface Focus. 6, 2, 14 p., 20150075.Research output: Contribution to journal › Article › Academic › peer-review
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