A systems biology approach to RESOLVE the molecular pathology of two hallmarks of patients with metabolic syndrome and its co-morbidities; hypertriglyceridemia and low HDL-cholesterol

van Riel, Natal A.W. (Project Manager)
Sips, Fianne L.P. (Project member)
Rozendaal, Yvonne J.W. (Project member)
Tiemann, Christian A. (Project member)
Groen, Bert (Program Manager)
Kuivenhoven, Jan A (PI)

Computational Biology

Project: Research direct

Description

Digital twin models for patients undergoing bariatric surgery to resolve metabolic syndrome.

Short title	RESOLVE FP7
Acronym	RESOLVE
Status	Finished
Effective start/end date	1/01/13 → 30/06/18

Collaborative partners

Eindhoven University of Technology
Amsterdam University Medical Center
University Medical Centre Groningen (lead)
University of Groningen

Keywords

hybrid machine learning model
ADAPT
multi-organ model
bile acids
gastric bypass surgery
multi-scale model
metabolic syndrome
genome-scale metabolic models
fatty liver disease

Topsector

TKI-LS&H

Access Project

https://cordis.europa.eu/project/id/305707

11 Article
5 Poster
3 Conference contribution
2 Abstract
More
- 1 Meeting Abstract

Does GLP-1 cause post-bariatric hypoglycemia: 'Computer says no'
Pasveer, Y. M., Aydin, Ö., Groen, A. K., Meijnikman, A. S., Nieuwdorp, M., Gerdes, V. E. A. & van Riel, N. A. W. (Corresponding author), Dec 2024, In: Computer Methods and Programs in Biomedicine. 257, 9 p., 108424.
Research output: Contribution to journal › Article › Academic › peer-review

Open Access
File
1 Link opens in a new tab Citation (Scopus)

55 Downloads (Pure)
Weight loss and metabolic changes in response to diet restriction and bariatric surgery
van Riel, N., 13 Sept 2024.
Research output: Contribution to conference › Abstract › Academic
A data-driven computational model for obesity-driven diabetes onset and remission through weight loss
Yildirim, V. (Corresponding author), Sheraton, V. M., Brands, R., Crielaard, L., Quax, R., van Riel, N. A. W., Stronks, K., Nicolaou, M. & Sloot, P. M. A., 17 Nov 2023, In: iScience. 26, 11, 25 p., 108324.
Research output: Contribution to journal › Article › Academic › peer-review

Open Access
File
7 Link opens in a new tab Citations (Scopus)

56 Downloads (Pure)

8 Invited talk
4 Contributed talk
3 Workshop, seminar, course or exhibition
1 Conference
More
- 1 Plenary talk

Mathematical modeling of the enterohepatic circulation
van Riel, N. A. W. (Speaker)
19 Nov 2025
Activity: Talk or presentation types › Invited talk › Scientific
Personalized modelling of bile acid metabolism: predicting metabolic effects of bariatric surgery
van Riel, N. (Speaker)
6 Jul 2018
Activity: Talk or presentation types › Invited talk › Scientific
A physiology based glucose-insulin-GLP-1 model: explaining changes observed after Roux-en-Y gastric bypass
Thijssen, L. C. P. (Speaker) & van Riel, N. (Member)
15 May 2018
Activity: Talk or presentation types › Contributed talk › Scientific

Studies Conducted at Amsterdam University Medical Center on Obesity and Diabetes Recently Reported (Bariatric Surgery Improves Postprandial Vldl Kinetics and Restores Insulin-mediated Regulation of Hepatic Vldl)
van Riel, N. A. W.
21/09/23
1 item of Media coverage
Press/Media: Expert Comment
New computational tool predicts progression of metabolic syndrome in mice
van Riel, N. & Rozendaal, Y. J. W.
7/06/18
1 Media contribution
Press/Media: Research
RESOLVE Metabolic Syndrome
van Riel, N.
11/10/17
1 Media contribution
Press/Media: Research

MATRyOShka: Metabolic adaptation, transitions and resilience in overweight individuals
van Riel, N. A. W. (Project Manager), O'Donovan, S. (Project member), Arts, I. C. W. (Project member) & Afman, L. A. (Project member)
1/10/17 → 30/06/23
Project: Research direct

A systems biology approach to RESOLVE the molecular pathology of two hallmarks of patients with metabolic syndrome and its co-morbidities; hypertriglyceridemia and low HDL-cholesterol

Project Details

Description

Collaborative partners

Keywords

Topsector

Access Project

Fingerprint

Does GLP-1 cause post-bariatric hypoglycemia: 'Computer says no'

Weight loss and metabolic changes in response to diet restriction and bariatric surgery

A data-driven computational model for obesity-driven diabetes onset and remission through weight loss

Mathematical modeling of the enterohepatic circulation

Personalized modelling of bile acid metabolism: predicting metabolic effects of bariatric surgery

A physiology based glucose-insulin-GLP-1 model: explaining changes observed after Roux-en-Y gastric bypass

Studies Conducted at Amsterdam University Medical Center on Obesity and Diabetes Recently Reported (Bariatric Surgery Improves Postprandial Vldl Kinetics and Restores Insulin-mediated Regulation of Hepatic Vldl)

New computational tool predicts progression of metabolic syndrome in mice

RESOLVE Metabolic Syndrome

MATRyOShka: Metabolic adaptation, transitions and resilience in overweight individuals

A systems biology approach to RESOLVE the molecular pathology of two hallmarks of patients with metabolic syndrome and its co-morbidities; hypertriglyceridemia and low HDL-cholesterol

Project Details

Description

Collaborative partners

Keywords

Topsector

Access Project

Fingerprint

Research output

Activities

Press/Media

Projects