Cells in our body are exceptionally robust: they constantly adapt their properties and behavior to their physical environment. Similarly, the environment surrounding the cells (‘extracellular matrix’) has to adapt to accommodate cell activity. Cells and the extracellular matrix are in constant communication with each other, and this communication is essential for the formation and functioning of new human tissue. Also, when this communication is impaired, a variety of diseases could arise, ranging from cardiomyopathies to cancer.