• 29 Citations
20172020

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Personal profile

Research profile

Xavier (1989) graduated in 2012 from the University of Nantes, France, with a MSc in Organic and Medicinal Chemistry after working on the final steps of the stereoselective synthesis of Fulvol Acetate, a biologically active compound presenting seven stereogenic centres on two six‑membered rings. Then, for his Ph.D. he joined a multidisciplinary research project involving a cluster of laboratories from Nantes. His Ph.D. research work was dedicated to the development of pH-sensitive injectable hydrogels made from functionalised polysaccharides. This kind of hydrogels being particularly promising as biomaterials in the regenerative medicine field.

In November 2016, Xavier started a post-doctoral position in the Chemical Biology Group (Biomedical Engineering department) at the Eindhoven University of Technology (TU/e). His research, carried out in Prof. Christian Ottmann’s group, is focused on the discovery and evaluation of novel bioactive small molecules for the inhibition and/or stabilization of 14-3-3 protein-protein interactions. To this end, Xavier uses a broad range of technics including synthetic chemistry, in silico design, biophysical assays (e.g. FP, ITC, MST), protein crystallography, solid-phase peptide synthesis, etc.

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Research Output

  • 29 Citations
  • 3 Article

Fragment-based Differential Targeting of PPI Stabilizer Interfaces

Guillory, X., Wolter, M., Leysen, S., Neves, J. F., Kuusk, A., Genet, S., Somsen, B., Morrow, J., Rivers, E., van Beek, L., Patel, J., Goodnow, R., Schoenherr, H., Fuller, N., Cao, Q., Doveston, R. G., Brunsveld, L., Arkin, M. R., Castaldi, M. P., Boyd, H. & 3 others, Landrieu, I., Chen, H. & Ottmann, C., 9 Jul 2020, In : Journal of Medicinal Chemistry. 63, 13, p. 6694–6707 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
  • Mono- and bivalent 14-3-3 inhibitors for characterizing supramolecular “Lysine Wrapping” of oligoethylene glycol (OEG) moieties in proteins

    Yilmaz, E., Bier, D., Guillory, X., Briels, J., Ruiz-Blanco, Y. B., Sanchez-Garcia, E., Ottmann, C. & Kaiser, M., 18 Sep 2018, In : Chemistry : A European Journal. 24, 52, p. 13807-13814 8 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    File
  • 3 Citations (Scopus)
    19 Downloads (Pure)

    The molecular tweezer CLR01 stabilizes a disordered protein-protein interface

    Bier, D., Mittal, S., Bravo-Rodriguez, K., Sowislok, A., Guillory, X. V., Briels, J., Heid, C., Bartel, M., Wettig, B., Brunsveld, L., Sanchez-Garcia, E., Schrader, T. & Ottmann, C., 15 Nov 2017, In : Journal of the American Chemical Society. 139, 45, p. 16256-16263 8 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    File
  • 26 Citations (Scopus)
    219 Downloads (Pure)