• 3043 Citations
20042019
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Personal profile

Quote

My overarching goal is to institutionalize nanotechnologies for precision immunotherapy and immuno-imaging. In addition to making such precision medicine approaches available to patients, I strive to cultivate a unique research environment for the next generation of biomedical engineers.   

Research profile

Willem Mulder is professor of Precision Medicine at the department of Biomedical Engineering. His main affiliation is with Mount Sinai’s Translational and Molecular Imaging Institute (TMII, Icahn School of Medicine, New York, USA) where he is a professor of Radiology and Oncological Sciences. His research focuses on precision imaging and targeted therapy in cardiovascular disease, cancer and transplantation. Mulder has established library technology, encompassing nanomaterials derived from natural lipoproteins, which allows meticulously designing nano-immunotherapies. When appropriately designed, such nano-immunotherapies can be applied to empower the immune system’s ability to fight disease, by promoting or inhibiting an immune response, by polarizing macrophage function, or by targeting myeloid cell dynamics. Concurrently, Mulder’s team develops methods that allow imaging immune response with high precision and non-invasively. Recently Mulder and co-workers presented the results of research regarding a mouse transplantation model where their nano-immunotherapy spectacularly promotes organ acceptance without the need for chronic immunosuppression in the journal 'Immunity'.

Academic background

Willem Mulder obtained his MSc in Chemistry from Utrecht University (the Netherlands) in 2001 and his PhD in Biomedical Engineering from Eindhoven University of Technology (TU/e, the Netherlands) in 2006. Thereafter, he was appointed assistant professor of Radiology at Mount Sinai’s Translational and Molecular Imaging Institute (TMII, Icahn School of Medicine at Mount SinaiNew York, USA) where he founded the Nanomedicine Laboratory. In 2012 he was appointed associate professor and in 2016 full professor of Radiology at Mount Sinai. In 2013, he received a Vidi grant by the Netherlands Organisation of Scientific Research (NWO) and was appointed as part-time professor of ‘Cardiovascular Nanomedicine' at the Academic Medical Center of the University of Amsterdam. In 2018, he was awarded a 1,5 million euro Vici grant by the Netherlands Organisation of Scientific Research NWO. He then moved to Eindhoven University of Technology (TU/e) to start his research group as professor of Precision Medicine at the TU/e department of Biomedical Engineering.

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Research Output 2004 2019

An iterative sparse deconvolution method for simultaneous multicolor 19F-MRI of multiple contrast agents

Schoormans, J., Calcagno, C., Daal, M. R. R., Wüst, R. C. I., Faries, C., Maier, A., Teunissen, A. J. P., Naidu, S., Sanchez-Gaytan, B. L., Nederveen, A. J., Fayad, Z. A., Mulder, W. J. M., Coolen, B. F. & Strijkers, G. J., 10 Jul 2019, (Accepted/In press) In : Magnetic Resonance in Medicine.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Contrast Media
Artifacts
Fluorine
Noise
Cell Tracking

Imaging-assisted nanoimmunotherapy for atherosclerosis in multiple species

Binderup, T., Duivenvoorden, R., Fay, F., van Leent, M. M. T., Malkus, J., Baxter, S., Ishino, S., Zhao, Y., Sanchez-Gaytan, B., Teunissen, A. J. P., Frederico, Y. C. A., Tang, J., Carlucci, G., Lyashchenko, S., Calcagno, C., Karakatsanis, N., Soultanidis, G., Senders, M. L., Robson, P. M., Mani, V. & 12 othersRamachandran, S., Lobatto, M. E., Hutten, B. A., Granada, J. F., Reiner, T., Swirski, F. K., Nahrendorf, M., Kjaer, A., Fisher, E. A., Fayad, Z. A., Pérez-Medina, C. & Mulder, W. J. M., 21 Aug 2019, In : Science Translational Medicine. 11, 506, eaaw7736

Research output: Contribution to journalArticleAcademicpeer-review

Atherosclerosis
Swine
Animal Models
Nanomedicine
Rabbits

Multimodal positron emission tomography imaging to quantify uptake of 89Zr-labeled liposomes in the atherosclerotic vessel wall

Lobatto, M. E., Binderup, T., Robson, P. M., Giesen, L. F. P., Calcagno, C., Witjes, J., Fay, F., Baxter, S., Wessel, C. H., Eldib, M., Bini, J., Carlin, S. D., Stroes, E. S. G., Storm, G., Kjaer, A., Lewis, J. S., Reiner, T., Fayad, Z. A., Mulder, W. J. M. & Pérez-Medina, C., 16 May 2019, In : Bioconjugate Chemistry.

Research output: Contribution to journalArticleAcademicpeer-review

Positron emission tomography
Liposomes
Positron-Emission Tomography
Nanoparticles
Magnetic resonance imaging
3 Citations (Scopus)

Nanoimmunotherapy to treat ischaemic heart disease

Duivenvoorden, R., Senders, M. L., van Leent, M. M. T., Pérez-Medina, C., Nahrendorf, M., Fayad, Z. A. & Mulder, W. J. M., 2019, In : Nature Reviews. Cardiology. 16, p. 21-32

Research output: Contribution to journalArticleAcademicpeer-review

Myocardial Ischemia
Atherosclerosis
Inflammation
Lipids
Recurrence
3 Citations (Scopus)

Therapeutic targeting of trained immunity

Mulder, W. J. M., Ochando, J., Joosten, L. A. B., Fayad, Z. A. & Netea, M. G., 9 Apr 2019, In : Nature Reviews Drug Discovery. 18, p. 553-566 14 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Immunity
Immunotherapy
Immune System
Immune System Diseases
Myeloid Cells

Prizes

Checkpoint NANO

Willem Mulder (Recipient), Nov 2018

Recognition: ERCConsolidatorScientific

Precision Medicine
Immune System
Research
Pharmaceutical Preparations
Immunotherapy

Student theses

Molecular imaging: characterization of novel lipid-based MR contrast agents

Author: van Heeswijk, R., 31 Dec 2004

Supervisor: Mulder, W. (Supervisor 1), Strijkers, G. (Supervisor 2) & Nicolaij, K. (Supervisor 2)

Student thesis: Master