• 3286 Citations
20042020

Research output per year

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Personal profile

Quote

My overarching goal is to institutionalize nanotechnologies for precision immunotherapy and immuno-imaging. In addition to making such precision medicine approaches available to patients, I strive to cultivate a unique research environment for the next generation of biomedical engineers.   

Research profile

Willem Mulder is professor of Precision Medicine at the department of Biomedical Engineering. His main affiliation is with Mount Sinai’s Translational and Molecular Imaging Institute (TMII, Icahn School of Medicine, New York, USA) where he is a professor of Radiology and Oncological Sciences. His research focuses on precision imaging and targeted therapy in cardiovascular disease, cancer and transplantation. Mulder has established library technology, encompassing nanomaterials derived from natural lipoproteins, which allows meticulously designing nano-immunotherapies. When appropriately designed, such nano-immunotherapies can be applied to empower the immune system’s ability to fight disease, by promoting or inhibiting an immune response, by polarizing macrophage function, or by targeting myeloid cell dynamics. Concurrently, Mulder’s team develops methods that allow imaging immune response with high precision and non-invasively. Recently Mulder and co-workers presented the results of research regarding a mouse transplantation model where their nano-immunotherapy spectacularly promotes organ acceptance without the need for chronic immunosuppression in the journal 'Immunity'.

Academic background

Willem Mulder obtained his MSc in Chemistry from Utrecht University (the Netherlands) in 2001 and his PhD in Biomedical Engineering from Eindhoven University of Technology (TU/e, the Netherlands) in 2006. Thereafter, he was appointed assistant professor of Radiology at Mount Sinai’s Translational and Molecular Imaging Institute (TMII, Icahn School of Medicine at Mount SinaiNew York, USA) where he founded the Nanomedicine Laboratory. In 2012 he was appointed associate professor and in 2016 full professor of Radiology at Mount Sinai. In 2013, he received a Vidi grant by the Netherlands Organisation of Scientific Research (NWO) and was appointed as part-time professor of ‘Cardiovascular Nanomedicine' at the Academic Medical Center of the University of Amsterdam. In 2018, he was awarded a 1,5 million euro Vici grant by the Netherlands Organisation of Scientific Research NWO. He then moved to Eindhoven University of Technology (TU/e) to start his research group as professor of Precision Medicine at the TU/e department of Biomedical Engineering.

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Research Output

An 89Zr-HDL PET Tracer Monitors Response to a CSF1R Inhibitor

Mason, C. A., Kossatz, S., Carter, L. M., Pirovano, G., Brand, C., Guru, N., Pérez-Medina, C., Lewis, J. S., Mulder, W. J. M. & Reiner, T., 1 Mar 2020, In : Journal of Nuclear Medicine. 61, 3, p. 433-436 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
  • 2 Citations (Scopus)

    Defining trained immunity and its role in health and disease

    Netea, M. G., Domínguez-Andrés, J., Barreiro, L. B., Chavakis, T., Divangahi, M., Fuchs, E., Joosten, L. A. B., van der Meer, J. W. M., Mhlanga, M. M., Mulder, W. J. M., Riksen, N. P., Schlitzer, A., Schultze, J. L., Stabell Benn, C., Sun, J. C., Xavier, R. J. & Latz, E., Jun 2020, In : Nature Reviews Immunology. 20, 6, p. 375–388 14 p.

    Research output: Contribution to journalReview articleAcademicpeer-review

    Open Access
  • 14 Citations (Scopus)

    Multimodal positron emission tomography imaging to quantify uptake of 89Zr-labeled liposomes in the atherosclerotic vessel wall

    Lobatto, M. E., Binderup, T., Robson, P. M., Giesen, L. F. P., Calcagno, C., Witjes, J., Fay, F., Baxter, S., Wessel, C. H., Eldib, M., Bini, J., Carlin, S. D., Stroes, E. S. G., Storm, G., Kjaer, A., Lewis, J. S., Reiner, T., Fayad, Z. A., Mulder, W. J. M. & Pérez-Medina, C., 19 Feb 2020, In : Bioconjugate Chemistry. 31, 2, p. 360-368 9 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  • 3 Citations (Scopus)

    Probing myeloid cell dynamics in ischaemic heart disease by nanotracer hot-spot imaging

    Senders, M. L., Meerwaldt, A. E., van Leent, M. M. T., Sanchez-Gaytan, B. L., van de Voort, J. C., Toner, Y. C., Maier, A., Klein, E. D., Sullivan, N. A. T., Sofias, A. M., Groenen, H., Faries, C., Oosterwijk, R. S., van Leeuwen, E. M., Fay, F., Chepurko, E., Reiner, T., Duivenvoorden, R., Zangi, L., Dijkhuizen, R. M. & 9 others, Hak, S., Swirski, F. K., Nahrendorf, M., Pérez-Medina, C., Teunissen, A. J. P., Fayad, Z. A., Calcagno, C., Strijkers, G. J. & Mulder, W. J. M., 1 May 2020, In : Nature Nanotechnology. 15, 5, p. 398-405 8 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  • 1 Citation (Scopus)

    Trained immunity in organ transplantation

    Ochando, J., Fayad, Z. A., Madsen, J. C., Netea, M. G. & Mulder, W. J. M., 1 Jan 2020, In : American Journal of Transplantation. 20, 1, p. 10-18 9 p.

    Research output: Contribution to journalReview articleAcademicpeer-review

    Open Access
  • 3 Citations (Scopus)

    Prizes

    Checkpoint NANO

    W.J.M. Mulder (Recipient), Nov 2018

    Prize: ERCConsolidatorScientific

  • Student theses

    Molecular imaging: characterization of novel lipid-based MR contrast agents

    Author: van Heeswijk, R., 31 Dec 2004

    Supervisor: Mulder, W. (Supervisor 1), Strijkers, G. (Supervisor 2) & Nicolaij, K. (Supervisor 2)

    Student thesis: Master