• 28 Citations
20182019
If you made any changes in Pure these will be visible here soon.

Research Output 2018 2019

  • 28 Citations
  • 10 Article
  • 1 Inaugural speech
2019
1 Citation (Scopus)
6 Downloads (Pure)

A CRISPR-Cas9 screen identifies essential CTCF anchor sites for estrogen receptor-driven breast cancer cell proliferation

Korkmaz, G., Manber, Z., Lopes, R., Prekovic, S., Schuurman, K., Kim, Y., Teunissen, H., Flach, K., Wit, E. D., Galli, G. G., Zwart, W., Elkon, R. & Agami, R., 10 Oct 2019, In : Nucleic Acids Research. 47, 18, p. 9557-9572 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Clustered Regularly Interspaced Short Palindromic Repeats
Estrogen Receptors
Cell Proliferation
Breast Neoplasms
Chromatin
2 Citations (Scopus)

CHD1 loss alters AR binding at lineage-specific enhancers and modulates distinct transcriptional programs to drive prostate tumorigenesis

Augello, M. A., Liu, D., Deonarine, L. D., Robinson, B. D., Huang, D., Stelloo, S., Blattner, M., Doane, A. S., Wong, E. W. P., Chen, Y., Rubin, M. A., Beltran, H., Elemento, O., Bergman, A. M., Zwart, W., Sboner, A., Dephoure, N. & Barbieri, C. E., 15 Apr 2019, In : Cancer Cell. 35, 4, p. 603-617.e8

Research output: Contribution to journalArticleAcademicpeer-review

Androgen Receptors
Prostate
Carcinogenesis
Neoplasms
Prostatic Neoplasms
1 Citation (Scopus)

Frequent clonal relations between metastases and non-index prostate cancer lesions

Kneppers, J., Krijgsman, O., Melis, M., de Jong, J., Peeper, D. S., Bekers, E., van der Poel, H. G., Zwart, W. T. & Bergman, A. M., 24 Jan 2019, In : JCI Insight. 4, 2, 9 p., e124756.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Prostatic Neoplasms
Neoplasm Metastasis
Lymph Nodes
Mortality
Therapeutics
1 Citation (Scopus)

GATA3 truncating mutations promote cistromic re-programming in vitro, but not mammary tumor formation in mice

Cornelissen, L. M., de Bruijn, R., Henneman, L., Kim, Y., Zwart, W. & Jonkers, J., 1 Sep 2019, In : Journal of Mammary Gland Biology and Neoplasia. 24, 3, p. 271-284 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Human Mammary Glands
Breast Neoplasms
Mutation
GATA3 Transcription Factor
Zinc Fingers
1 Downloads (Pure)

Genomic data integration by WON-PARAFAC identifies interpretable factors for predicting drug-sensitivity in vivo

Kim, Y., Bismeijer, T., Zwart, W., Wessels, L. F. A. & Vis, D. J., 1 Dec 2019, In : Nature Communications. 10, 1, 12 p., 5034.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
data integration
factor analysis
Data integration
Factor analysis
Statistical Factor Analysis
41 Downloads (Pure)

Het fundament van maatwerk

Zwart, W., 10 May 2019, Eindhoven: Technische Universiteit Eindhoven. 32 p.

Research output: Book/ReportInaugural speechAcademic

Open Access
File
5 Citations (Scopus)
24 Downloads (Pure)

Optimized ChIP-seq method facilitates transcription factor profiling in human tumors

Singh, A. A., Schuurman, K., Nevedomskaya, E., Stelloo, S., Linder, S., Droog, M., Kim, Y., Sanders, J., van der Poel, H., Bergman, A. M., Wessels, L. F. A. & Zwart, W., Feb 2019, In : Life Science Alliance. 2, 1, 12 p., e201800115.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Chromatin Immunoprecipitation
tumor
Chromatin
chromatin
Tumors
2018
2 Citations (Scopus)
37 Downloads (Pure)

Enzalutamide therapy for advanced prostate cancer: efficacy, resistance and beyond

Linder, S., van der Poel, H. G., Bergman, A. M., Zwart, W. & Prekovic, S., 31 Oct 2018, In : Endocrine-related cancer. 26, 1, p. R31-R52 22 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Prostatic Neoplasms
Castration
Therapeutics
Androgen Receptor Antagonists
Translational Medical Research
4 Citations (Scopus)
13 Downloads (Pure)

FOXA1 levels are decreased in pleural breast cancer metastases after adjuvant endocrine therapy, and this is associated with poor outcome

Schrijver, W., Schuurman, K., van Rossum, A., Droog, M., Jeronimo, C., Salta, S., Henrique, R., Wesseling, J., Moelans, C., Linn, S. C., van den Heuvel, M., van Diest, P. & Zwart, W., Nov 2018, In : Molecular Oncology. 12, 11, p. 1884-1894 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Estrogen Receptor alpha
Breast Neoplasms
Neoplasm Metastasis
Therapeutics
Cell Proliferation
8 Citations (Scopus)
99 Downloads (Pure)

Integrative epigenetic taxonomy of primary prostate cancer

Stelloo, S., Nevedomskaya, E., Kim, Y., Schuurman, K., Valle-Encinas, E., Lobo, J., Krijgsman, O., Peeper, D. S., Chang, S. L., Feng, F. Y. C., Wessels, L. F. A., Henrique, R., Jerónimo, C., Bergman, A. M. & Zwart, W., 21 Nov 2018, In : Nature Communications. 9, 1, 1 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
taxonomy
Androgen Receptors
Taxonomies
Epigenomics
Prostatic Neoplasms
4 Citations (Scopus)

Molecular underpinnings of enzalutamide resistance

Prekovic, S., van den Broeck, T., Linder, S., van Royen, M. E., Houtsmuller, A. B., Handle, F., Joniau, S., Zwart, W. & Claessens, F., 1 Nov 2018, In : Endocrine-related cancer. 25, 11, p. R545-R557 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Prostatic Neoplasms
Androgen Receptors
Second Primary Neoplasms
Therapeutics
Hormones