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Personal profile

Quote

"In scientific research, it is important to never reach a steady state."

Research profile

Research in the Noël group encompasses the development of new catalytic strategies and technologies for chemical synthesis. The catalytic targets are chosen in such a way that continuous-flow microreactors and chemical engineering principles can make a substantial impact. By building bridges between chemical engineering and organic synthetic chemistry, long-standing problems in synthetic chemistry can be overcome. These includes scalability, gas-liquid reactions, photochemistry, electrochemistry and the generation and use of hazardous reagents. The unique approach at the interface of organic synthetic chemistry and chemical engineering enables the Noël group to rapidly recognize those synthetic problems that would benefit from microreactor technology.

The group strives to develop new technological tools that are of interest to the pharmaceutical industry and can overcome challenges in a variety of specialty applications, e.g. organic synthesis, chemical biology, material science, etc. The ambition is to develop new catalytic strategies for chemical synthesis that engage novel reactivity concepts which facilitate the rapid generation of biologically active molecules. In the long run this would lead to an automated and chemo-catalytic equivalent to Nature’s biosynthetic machinery that is able to build essentially any molecule on demand.

Academic background

Timothy Noël obtained his MSc in Industrial Chemical Engineering from KaHo Sint Lieven (Ghent, Belgium) in 2004. In 2009, he received his PhD at the Laboratory for Organic and Bioorganic Synthesis at Ghent University under supervision of Prof. Johan Van der Eycken with his thesis 'Synthesis and application of chiral dienes and chiral imidates for asymmetric transition metal catalysis'. He then moved to the Massachusetts Institute of Technology as a Fulbright Postdoctoral Fellow with Prof. Stephen L. Buchwald (MIT-Novartis Center for Continuous Manufacturing) where he worked on the development of new continuous-flow methods for cross-coupling chemistry. In 2012 he was appointed assistant professor at Eindhoven University of Technology (TU/e) and in 2017 associate professor with the research group Micro Flow Chemistry and Process Technology.

Affiliated with

  • Flow Chemistry Society
  • Ghent University

Partners in (semi-)industry

  • AbbVie
  • InnoStudio Scientific Advisory Board member

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2011 2019

39 Citations (Scopus)

A leaf-inspired luminescent solar concentrator for energy-efficient continuous-flow photochemistry

Cambié, D., Zhao, F., Hessel, V., Debije, M. G. & Noël, T., 19 Jan 2017, In : Angewandte Chemie - International Edition. 56, 4, p. 1050-1054 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Solar concentrators
Photochemical reactions
Polydimethylsiloxane
Microchannels
Fluorescent Dyes
29 Citations (Scopus)

A modular flow design for the meta-selective C-H arylation of anilines

Gemoets, H. P. L., Laudadio, G., Verstraete, K., Hessel, V. & Noël, T., 12 Jun 2017, In : Angewandte Chemie - International Edition. 56, 25, p. 7161-7165 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Aniline Compounds
Aniline
Copper
Column chromatography
Salts
23 Citations (Scopus)

An environmentally benign and selective electrochemical oxidation of sulfides and thiols in a continuous-flow microreactor

Laudadio, G., Straathof, N. J. W., Lanting, M. D., Knoops, B., Hessel, V. & Noël, T., 7 Aug 2017, In : Green Chemistry. 19, p. 4061-4066 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Electrochemical oxidation
thiol
Sulfides
Sulfhydryl Compounds
sulfide

Application of metal oxide semiconductors in light-driven organic transformations

Riente Paiva, P. & Noël, T., 22 Aug 2019, In : Catalysis Science & Technology. 9, 19, p. 5186-5232 47 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Metals
Photocatalysts
Chemical stability
Transition metals
Energy efficiency
1 Citation (Scopus)

De novo design of organic photocatalysts: bithiophene derivatives for the visible-light induced C−H functionalization of heteroarenes

Bottecchia, C., Martín, R., Abdiaj, I., Crovini, E., Alcazar, J., Orduna, J., Blesa, M. J., Carrillo, J. R., Prieto, P. & Noël, T., 5 Mar 2019, In : Advanced Synthesis & Catalysis. 361, 5, p. 945-950

Research output: Contribution to journalArticleAcademicpeer-review

Photocatalysts
Derivatives
Catalysts
Discrete Fourier transforms
Absorption spectra

Prizes

NWO Veni Award : Breakthrough in drug development

Timothy Noël (Recipient), 2012

Recognition: NWOVeniScientific

Fluorine
Pharmaceutical Preparations
Research Personnel

NWO Vidi Award : Home run for photochemistry!

Timothy Noël (Recipient), 2014

Recognition: NWOVidiScientific

Photochemical reactions
Chemical reactions
Catalysts

Press / Media

Photo-catalysis for greener, faster manufacturing

Timothy Noël

17/11/17

1 item of media coverage

Press/Media: Expert Comment

Flow process streamlines assembly of essential antibiotic

Timothy Noël

24/08/17

1 item of media coverage

Press/Media: Expert Comment

Student theses

A broadly applicable red dye doped Luminescent Solar Concentrator photo microreactor

Author: Dobbelaar, J., May 2017

Supervisor: Cambié, D. (Supervisor 1), Noël, T. (Supervisor 2), Hessel, V. (Supervisor 2) & Debije, M. (Supervisor 2)

Student thesis: Master

Accurate measurements of the photon flux in multiphase reactor systems by actinometry

Author: Verijke, R., 30 Apr 2016

Supervisor: Noël, T. (Supervisor 1), Su, Y. (Supervisor 2), Hessel, V. (Supervisor 2) & Roghair, I. (External coach)

Student thesis: Master

File

A comparison between classical cross-coupling and C-H activation via experiments, cost analysis and green metrics

Author: Schouten, A., 31 Aug 2016

Supervisor: Gemoets, H. (Supervisor 1), Noël, T. (Supervisor 2), Hessel, V. (Supervisor 2) & Peters, E. (External coach)

Student thesis: Master

A convenient internal numbering-up strategy for the scale up of gas-liquid photoredox catalysis

Author: Kuijpers, K. P., 31 Jan 2016

Supervisor: Su, Y. (Supervisor 1), Noël, T. (Supervisor 2), Hessel, V. (Supervisor 2) & Padding, J. (External coach)

Student thesis: Master

File

Arylation of cysteine residues via photoredox catalysis in batch and flow

Author: van den Bosch, M., 31 Aug 2017

Supervisor: Noël, T. (Supervisor 1)

Student thesis: Master

File