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Personal profile

Quote

"In scientific research, it is important to never reach a steady state."

Research profile

Research in the Noël group encompasses the development of new catalytic strategies and technologies for chemical synthesis. The catalytic targets are chosen in such a way that continuous-flow microreactors and chemical engineering principles can make a substantial impact. By building bridges between chemical engineering and organic synthetic chemistry, long-standing problems in synthetic chemistry can be overcome. These includes scalability, gas-liquid reactions, photochemistry, electrochemistry and the generation and use of hazardous reagents. The unique approach at the interface of organic synthetic chemistry and chemical engineering enables the Noël group to rapidly recognize those synthetic problems that would benefit from microreactor technology.

The group strives to develop new technological tools that are of interest to the pharmaceutical industry and can overcome challenges in a variety of specialty applications, e.g. organic synthesis, chemical biology, material science, etc. The ambition is to develop new catalytic strategies for chemical synthesis that engage novel reactivity concepts which facilitate the rapid generation of biologically active molecules. In the long run this would lead to an automated and chemo-catalytic equivalent to Nature’s biosynthetic machinery that is able to build essentially any molecule on demand.

Academic background

Timothy Noël obtained his MSc in Industrial Chemical Engineering from KaHo Sint Lieven (Ghent, Belgium) in 2004. In 2009, he received his PhD at the Laboratory for Organic and Bioorganic Synthesis at Ghent University under supervision of Prof. Johan Van der Eycken with his thesis 'Synthesis and application of chiral dienes and chiral imidates for asymmetric transition metal catalysis'. He then moved to the Massachusetts Institute of Technology as a Fulbright Postdoctoral Fellow with Prof. Stephen L. Buchwald (MIT-Novartis Center for Continuous Manufacturing) where he worked on the development of new continuous-flow methods for cross-coupling chemistry. In 2012 he was appointed assistant professor at Eindhoven University of Technology (TU/e) and in 2017 associate professor with the research group Micro Flow Chemistry and Process Technology.

Affiliated with

  • Flow Chemistry Society
  • Ghent University

Partners in (semi-)industry

  • AbbVie
  • InnoStudio Scientific Advisory Board member

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Research Output

A leaf-inspired luminescent solar concentrator for energy-efficient continuous-flow photochemistry

Cambié, D., Zhao, F., Hessel, V., Debije, M. G. & Noël, T., 19 Jan 2017, In : Angewandte Chemie - International Edition. 56, 4, p. 1050-1054 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
  • 50 Citations (Scopus)
    246 Downloads (Pure)

    A modular flow design for the meta-selective C-H arylation of anilines

    Gemoets, H. P. L., Laudadio, G., Verstraete, K., Hessel, V. & Noël, T., 12 Jun 2017, In : Angewandte Chemie - International Edition. 56, 25, p. 7161-7165 5 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    File
  • 32 Citations (Scopus)
    101 Downloads (Pure)

    An environmentally benign and selective electrochemical oxidation of sulfides and thiols in a continuous-flow microreactor

    Laudadio, G., Straathof, N. J. W., Lanting, M. D., Knoops, B., Hessel, V. & Noël, T., 7 Aug 2017, In : Green Chemistry. 19, 17, p. 4061-4066 6 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    File
  • 42 Citations (Scopus)
    143 Downloads (Pure)

    Accelerating sulfonyl fluoride synthesis through electrochemical oxidative coupling of thiols and potassium fluoride in flow

    Cao, Y., Adriaenssens, B., de Andrade Bartolomeu, A., Laudadio, G., de Oliveira, K. T. & Noël, T., 1 Mar 2020, In : Journal of Flow Chemistry. 10, 1, p. 191-197 7 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    File
  • 1 Citation (Scopus)
    13 Downloads (Pure)

    A letter to the flow community

    Noël, T., 1 Jun 2020, In : Journal of Flow Chemistry. 10, 2, p. 363 1 p.

    Research output: Contribution to journalEditorialAcademicpeer-review

    Open Access

    Prizes

    NWO Veni Award : Breakthrough in drug development

    T. Noël (Recipient), 2012

    Prize: NWOVeniScientific

  • NWO Vidi Award : Home run for photochemistry!

    T. Noël (Recipient), 2014

    Prize: NWOVidiScientific

  • Press / Media

    Can an artificial leaf make the pharmaceutical industry greener?

    Timothy Noël

    11/09/1912/09/19

    2 items of Media coverage

    Press/Media: Expert Comment

    This Synthetic Leaf Turns Sunlight Into Drugs

    Timothy Noël

    11/09/1912/09/19

    3 items of Media coverage

    Press/Media: Expert Comment

    Researchers produce medicine from sunlight from ‘artificial leaf’

    Timothy Noël

    9/09/19

    1 item of Media coverage

    Press/Media: Expert Comment

    Student theses

    A broadly applicable red dye doped Luminescent Solar Concentrator photo microreactor

    Author: Dobbelaar, J., 29 Nov 2017

    Supervisor: Cambié, D. (Supervisor 1), Noël, T. (Supervisor 2), Hessel, V. (Supervisor 2) & Debije, M. (Supervisor 2)

    Student thesis: Master

    File

    Accurate measurements of the photon flux in multiphase reactor systems by actinometry

    Author: Verijke, R., 30 Apr 2016

    Supervisor: Noël, T. (Supervisor 1), Su, Y. (Supervisor 2), Hessel, V. (Supervisor 2) & Roghair, I. (External coach)

    Student thesis: Master

    File

    A comparison between classical cross-coupling and C-H activation via experiments, cost analysis and green metrics

    Author: Schouten, A., 31 Aug 2016

    Supervisor: Gemoets, H. (Supervisor 1), Noël, T. (Supervisor 2), Hessel, V. (Supervisor 2) & Peters, E. (External coach)

    Student thesis: Master

    A convenient internal numbering-up strategy for the scale up of gas-liquid photoredox catalysis

    Author: Kuijpers, K. P., 31 Jan 2016

    Supervisor: Su, Y. (Supervisor 1), Noël, T. (Supervisor 2), Hessel, V. (Supervisor 2) & Padding, J. (External coach)

    Student thesis: Master

    File

    Arylation of cysteine residues via photoredox catalysis in batch and flow

    Author: van den Bosch, M., 31 Aug 2017

    Supervisor: Noël, T. (Supervisor 1)

    Student thesis: Master

    File