• 7 Citations
20182019
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Personal profile

Research profile

Simone Wouters received her Bachelor degree Biomedical Engineering in 2013. She continued at the Eindhoven University of Technology with her master degree Biomedical Engineering in the Protein Engineering research group of Prof. dr. M. Merkx. During her master thesis she developed light-switchable 14-3-3 proteins. She currently holds a PhD position in the same group where her research is focussed on the controlled activation of antibodies. A bivalent DNA-based ligand was developed to block the antigen-binding sites of antibodies. By using external triggers, that disrupt the bivalency of the ligand, the inhibition of the antibody can be reversed. Protease cleavage and strand-displacement have already been used as trigger. During the project, Simone will extend the triggers and use the system to control therapeutic antibodies such as Cetuximab.

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  • 13 Similar Profiles
Scaffolds (biology) Engineering & Materials Science
Scaffolds Chemical Compounds
Peptides Chemical Compounds
Peptide Hydrolases Chemical Compounds
Proteins Engineering & Materials Science
Antibodies Chemical Compounds
DNA Chemical Compounds
Caspase 9 Chemical Compounds

Research Output 2018 2019

  • 7 Citations
  • 2 Article
2 Citations (Scopus)
11 Downloads (Pure)

Optical control of antibody activity using photocleavable bivalent peptide-DNA locks

Wouters, S., Wijker, E. & Merkx, M., 1 Oct 2019, In : ChemBioChem. 20, 19, p. 2463-2466 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Peptides
Antibodies
DNA
Ligands
Light
5 Citations (Scopus)
48 Downloads (Pure)

Protease-activatable scaffold proteins as versatile molecular hubs in synthetic signaling networks

Aper, S. J. A., den Hamer, A., Wouters, S., Lemmens, L., Ottmann, C., Brunsveld, L. & Merkx, M., 20 Aug 2018, In : ACS Synthetic Biology. 7, 9, p. 2216-2225

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Scaffolds (biology)
Scaffolds
Peptide Hydrolases
Proteins
Caspase 9

Student theses

Bioluminescent labeled antibodies for detection of colorectal cancer

Author: Vugs, W., 29 Aug 2019

Supervisor: Wouters, S. (Supervisor 1) & Merkx, M. (Supervisor 2)

Student thesis: Master