• 2150 Citations
20022020
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Personal profile

Quote

"Combining biology with technological solutions will lead to medical progress. However, extensive efforts are required to bridge the gap between discovery, invention and application."

Research profile

Simon Hoestrup is part-time professor at the department of Biomedical Engineering (research group Soft Tissue Engineering and Mechanobiology). He is Chair and Director of the Institute for Regenerative Medicine (University Zurich) and Founding Co-Director of the Wyss Zurich (University Zurich & ETH Zurich) in Switzerland. His work at the interface of basic science and translational research has resulted in more than 150 peer-reviewed scientific publications and a unique patent portfolio in the field of Regenerative Medicine. Hoerstrup leads several major scientific international consortia projects funded by the European Commission, the Swiss National Science Foundation, Commission for Technology and Innovation, etc.

Academic background

Simon P. Hoerstrup studied medicine at the University of Cologne with electives in Switzerland (University of Berne) and the USA (Baylor College of Medicine and Texas Heart Institute, Houston; Harvard Medical School, Boston). After graduation in 1995, he received his Medical Doctor (M.D.) degree (magna cum laude) from the University of Cologne and started his clinical education in Cardiovascular Surgery at the University Hospital Zürich, Switzerland. From 1998-2000, he received a research grant of the German Research Foundation and Harvard Medical School to become research fellow at Children’s Hospital Boston, Harvard Medical School. In 2001, he received his 'Habilitation' (Privatdozent Dr. med.) from the Medical Faculty of the University of Zürich, Switzerland. In 2003, he was appointed part-time professor at the department of Biomedical Engineering of Eindhoven University of Technology (TU/e). Currently, he is Chair and Director of the Institute for Regenerative Medicine (University Zurich) and Founding Co-Director of the Wyss Zurich (University Zurich & ETH Zurich) in Switzerland. He also is Associate Member of the Department of Health Science Technology at the Swiss Federal Institute of Technology (ETH) and associate faculty of the Harvard Wyss Institute for Biologically Inspired Engineering in Boston (USA). Furthermore, Hoerstrup is co-founder of a series of medtech and biotech spin-off companies (Symetis AG, Xeltis AG, Insphero AG, etc.).

External positions

University Hospital Zürich

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  • 15 Similar Profiles
Heart Valves Medicine & Life Sciences
Tissue Engineering Medicine & Life Sciences
Sheep Medicine & Life Sciences
Pulmonary Valve Medicine & Life Sciences
Tissue Engineering & Materials Science
Tissue engineering Engineering & Materials Science
Stents Medicine & Life Sciences
Stem Cells Medicine & Life Sciences

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Research Output 2002 2020

1 Citation (Scopus)
3 Downloads (Pure)

Differential leaflet remodeling of bone marrow cell pre-seeded versus nonseeded bioresorbable transcatheter pulmonary valve replacements

Fioretta, E., Lintas, V., Mallone, A., Motta, S. E., von Boehmer, L., Dijkman, P. E., Cesarovic, N., Caliskan, E., Rodriguez Cetina Biefer, H., Lipiski, M., Sauer, M., Putti, M., Janssen, H. M., Söntjens, S. H. M., Smits, A. I. P. M., Bouten, C. V. C., Emmert, M. Y. & Hoerstrup, S. P., 1 Jan 2020, In : JACC: Basic to Translational Science. 5, 1, p. 15-31 17 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Pulmonary Valve
Heart Valves
Bone Marrow Cells
polycarbonate
Sheep
24 Citations (Scopus)
16 Downloads (Pure)

Computational modeling guides tissue-engineered heart valve design for long-term in vivo performance in a translational sheep model

Emmert, M. Y., Schmitt, B. A., Loerakker, S., Sanders, B., Spriestersbach, H., Fioretta, E. S., Bruder, L., Brakmann, K., Motta, S. E., Lintas, V., Dijkman, P. E., Frese, L., Berger, F., Baaijens, F. P. T. & Hoerstrup, S. P., 9 May 2018, In : Science Translational Medicine. 10, 440, 13 p., eaan4587.

Research output: Contribution to journalArticleAcademicpeer-review

Heart Valves
Sheep
Tissue Engineering
Bioengineering
Heart Valve Prosthesis
1 Citation (Scopus)

Puncturing of lyophilized tissue engineered vascular matrices enhances the efficiency of their recellularization

Ksiazek, A. A., Frese, L., Dijkman, P. E., Sanders, B., Motta, S. E., Weber, B. & Hoerstrup, S. P., 15 Apr 2018, In : Acta Biomaterialia. 71, p. 474-485

Research output: Contribution to journalArticleAcademicpeer-review

Piercing
Grafts
Blood Vessels
Tissue
Transplants
16 Citations (Scopus)
764 Downloads (Pure)

The future of heart valve replacement: recent developments and translational challenges for heart valve tissue engineering

Fioretta, E. S., Dijkman, P. E., Emmert, M. Y. & Hoerstrup, S. P., 1 Jan 2018, In : Journal of Tissue Engineering and Regenerative Medicine. 12, 1, p. e323-e335

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Heart Valves
Tissue Engineering
Tissue engineering
Heart Valve Diseases
Starters
2 Citations (Scopus)

Are adipose-derived stem cells cultivated in human platelet lysate suitable for heart valve tissue engineering?

Frese, L., Sasse, T., Sanders, B., Baaijens, F. P. T., Beer, G. M. & Hoerstrup, S. P., 18 Aug 2017, In : Journal of Tissue Engineering and Regenerative Medicine. 11, 8, p. 2193-2203 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Heart Valves
Tissue Engineering
Platelets
Stem cells
Tissue engineering

Student theses

Influence of material choice and surface structure on cell behaviour

Author: Ronken, S., 31 Mar 2009

Supervisor: Hoerstrup, S. (Supervisor 1), Baaijens, F. (Supervisor 2), Schmidt, D. (External person) (External coach) & Driessen - Mol, A. (Supervisor 2)

Student thesis: Master