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Personal profile

Research profile

Sebastiaan Overeem is Full Professor in the Signal Processing Systems group (Department of Electrical Engineering). He is a clinical somnologist and a neuroscientist, holding the chair Intelligent Systems for Sleep Disorders. He focuses on the development, validation and implementation of new diagnostic methods for sleep and sleep disorders.

Overeem has a broad interest and experience in the field of sleep medicine.  One focus over the last 15 years has been on narcolepsy, including the neurophysiology of cataplexy and the biology of the hypocretin system. The hypocretin-system formed the initial connecting link to sleep in Parkinson’s disease, when it was shown that hypocretin defects are present in Parkinson’s as a cause of sleep disturbances. This work led to a research line on sleep disorders in neurodegenerative disease, which is how Overeem was first appointed researcher at Eindhoven University of Technology (TU/e).

Within the framework of the Eindhoven MedTech Innovation Center, Overeem is participating in a various research efforts aiming to improve the diagnosis of sleep disorders, by developing and validating new non-obtrusive measurement modalities. Importantly, besides objective measures, the assessement of subjective sleep experience and symptoms is an integral topic of research.

His clinical work as a sleep medicine specialist takes place at the Center for Sleep Medicine Kempenhaeghe.

Academic background

Sebastiaan Overeem holds a PhD (2003) and MD (2004) from Leiden University. Part of his theis work took place at the Center for Narcolepsy Research at Stanford University. After graduating, he worked as Assistant Professor in the Department of Neurology at Radboud University Medical Center from 2005 to 2015. In 2008, he took up the position of somnologist at expertise center Kempenhaeghe. Overeem joined Eindhoven University of Technology (TU/e) as Senior Researcher in 2015 and was appointed professor in 2017.


“Technological developments in the area of sleep diagnostics are essential to improve the care for patients with sleep disorders, diseases with a tremendous impact on quality of life.”

External positions

somnologist, Kempenhaeghe

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Narcolepsy Medicine & Life Sciences
Sleep Medicine & Life Sciences
Parkinson Disease Medicine & Life Sciences
Cataplexy Medicine & Life Sciences
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Polysomnography Medicine & Life Sciences
Sleep Initiation and Maintenance Disorders Medicine & Life Sciences
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Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2009 2020

A mobile app for longterm monitoring of narcolepsy symptoms: design, development, and evaluation

Quaedackers, L., de Wit, J., Pillen, S., van Gilst, M., Batalas, N., Lammers, G. J., Markopoulos, P. & Overeem, S., 7 Jan 2020, In : JMIR Mhealth and Uhealth. 8, 1, 14 p., e14939.

Research output: Contribution to journalArticleAcademicpeer-review

Mobile Applications
Sleep Paralysis
2 Citations (Scopus)
1 Downloads (Pure)

Brain glucose metabolism heterogeneity in idiopathic REM sleep behavior disorder and in Parkinson's disease

Arnaldi, D., Meles, S. K., Giuliani, A., Morbelli, S., Renken, R. J., Janzen, A., Sittig-Wiegand, E., Depboylu, C., Reetz, K., Overeem, S., Pijpers, A., Reesink, F. E., Van Laar, T., Teune, L. K., Höffken, H., Luster, M., Timmermann, L., Kesper, K., Adriaanse, S. M., Booij, J. & 2 others, Sambuceti, G. & Girtler, N., 1 Jan 2019, In : Journal of Parkinson's Disease. 9, 1, p. 229-239 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

4 Downloads (Pure)

Design and evaluation of a negotiation-based sleep scheduler app for insomnia treatment

Erten-Uyumaz, B., Ahuja, M., Vacaretu, T., Rama, M. D., Overeem, S., Visser, T., Hu, J. & Feijs, L., 20 May 2019, Proceedings of the 13th EAI International Conference on Pervasive Computing Technologies for Healthcare, PervasiveHealth 2019. ACM/IEEE, p. 225-233 9 p.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Sleep Initiation and Maintenance Disorders
Appointments and Schedules
5 Citations (Scopus)
85 Downloads (Pure)

Determinants of perceived sleep quality in normal sleepers

Goelema, M. S., Regis, M., Haakma, R., van den Heuvel, E. R., Markopoulos, P. & Overeem, S., 2019, In : Behavioral Sleep Medicine. 17, 4, p. 388-397 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
4 Downloads (Pure)
Open Access
Obstructive Sleep Apnea


Activities 2012 2019

  • 1 Workshop, seminar, course or exhibition
  • 1 Editorial activity
  • 1 Keynote talk
  • 1 Plenary talk

Developments in the assessment of sleep and circadian rhythms

Sebastiaan Overeem (Organiser)
10 May 2019

Activity: Participating in or organising an event typesWorkshop, seminar, course or exhibitionScientific

Waarom kan je je niet herinneren dat je in slaap bent gevallen?

Sebastiaan Overeem (Speaker)
2 May 2019

Activity: Talk or presentation typesKeynote talkPopular

A Somnologist's Dream

Sebastiaan Overeem (Speaker)
19 Jan 2018

Activity: Talk or presentation typesPlenary talkProfessional

Sleep Medicine Reviews (Journal)

Sebastiaan Overeem (Editorial board member)
2012 → …

Activity: Publication peer-review and editorial work typesEditorial activityScientific

Press / Media

Apneu beu

Sebastiaan Overeem


1 Media contribution

Press/Media: Expert Comment

Voor opsporen slaapapneu is [dit] wellicht niet meer nodig

Sebastiaan Overeem


1 Media contribution

Press/Media: Expert Comment

Detecting sleep apnea in your own bed

Sebastiaan Overeem


2 items of Media coverage

Press/Media: Expert Comment

Slaapapneu opsporen vanuit je eigen bed

Sebastiaan Overeem


1 Media contribution

Press/Media: Expert Comment

Student theses

Design for sleep paralysis

Author: Matthijsse, D., 2016

Supervisor: Hu, J. (Supervisor 1), Markopoulos, P. (Supervisor 2), Overeem, S. (Supervisor 2), Tao, L. (Supervisor 2) & de Wit, J. (Supervisor 2)

Student thesis: Bachelor