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Personal profile

Research profile

Sebastiaan Overeem is Full Professor in the Signal Processing Systems group (Department of Electrical Engineering). He is a clinical somnologist and a neuroscientist, holding the chair Intelligent Systems for Sleep Disorders. He focuses on the development, validation and implementation of new diagnostic methods for sleep and sleep disorders.

Overeem has a broad interest and experience in the field of sleep medicine.  One focus over the last 15 years has been on narcolepsy, including the neurophysiology of cataplexy and the biology of the hypocretin system. The hypocretin-system formed the initial connecting link to sleep in Parkinson’s disease, when it was shown that hypocretin defects are present in Parkinson’s as a cause of sleep disturbances. This work led to a research line on sleep disorders in neurodegenerative disease, which is how Overeem was first appointed researcher at Eindhoven University of Technology (TU/e).

Within the framework of the Eindhoven MedTech Innovation Center, Overeem is participating in a various research efforts aiming to improve the diagnosis of sleep disorders, by developing and validating new non-obtrusive measurement modalities. Importantly, besides objective measures, the assessement of subjective sleep experience and symptoms is an integral topic of research.

His clinical work as a sleep medicine specialist takes place at the Center for Sleep Medicine Kempenhaeghe.

Academic background

Sebastiaan Overeem holds a PhD (2003) and MD (2004) from Leiden University. Part of his theis work took place at the Center for Narcolepsy Research at Stanford University. After graduating, he worked as Assistant Professor in the Department of Neurology at Radboud University Medical Center from 2005 to 2015. In 2008, he took up the position of somnologist at expertise center Kempenhaeghe. Overeem joined Eindhoven University of Technology (TU/e) as Senior Researcher in 2015 and was appointed professor in 2017.


“Technological developments in the area of sleep diagnostics are essential to improve the care for patients with sleep disorders, diseases with a tremendous impact on quality of life.”

External positions

somnologist, Kempenhaeghe

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Research Output

A mobile app for longterm monitoring of narcolepsy symptoms: design, development, and evaluation

Quaedackers, L., de Wit, J., Pillen, S., van Gilst, M., Batalas, N., Lammers, G. J., Markopoulos, P. & Overeem, S., 7 Jan 2020, In : JMIR Mhealth and Uhealth. 8, 1, 14 p., e14939.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
  • 14 Downloads (Pure)

    A new incidence peak of childhood narcolepsy type 1 in 2013: a new perspective on the role of influenza virus?

    Zhang, Z., Gool, J., Fronczek, R., Bassetti, C., Dauvilliers, Y., Mayer, G., Plazzi, G., Pizza, F., Santamaria, J., Partinen, M., Overeem, S., Peraita-Adrados, R., Sonka, K., Del Rio-Villegas, R., Heinzer, R., Wierzbicka, A., Hoegl, B., Young, P., Martins Da Silva, A., Manconi, M. & 9 others, Feketeova, E., Mathis, J., Paiva, T., Canellas, F., Lecendreux, M., Baumann, C., Haba-Rubio, J., Lammers, G. J. & Khatami, R., May 2020, In : European Journal of Neurobiology. 27, p. 101-102

    Research output: Contribution to journalMeeting AbstractAcademic

    Automatic sleep staging using heart rate variability, body movements, and recurrent neural networks in a sleep disordered population

    Fonseca, P., van Gilst, M. M., Radha, M., Ross, M., Moreau, A., Cerny, A., Anderer, P., Long, X., van Dijk, J. P. & Overeem, S., 6 Apr 2020, In : Sleep.

    Research output: Contribution to journalArticleAcademicpeer-review

  • HLA associations in narcolepsy type 1 persist after the 2009 H1N1 pandemic

    Schinkelshoek, M., Fronczek, R., Verduijn, W., Haasnoot, G., Overeem, S., Donjacour, C., van der Heide, A., Roelen, D., Claas, F. & Lammers, G. J., 15 May 2020, In : Journal of Neuroimmunology. 342, 5 p., 577210.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
  • 3 Downloads (Pure)

    Lying awake at night: cardiac autonomic activity in relation to sleep onset and maintenance

    Nano, M., Fonseca, P., Overeem, S., Vullings, R. & Aarts, R. M., 15 Jan 2020, In : Frontiers in Neuroscience. 13, 13 p., 1405.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    12 Downloads (Pure)



    • 1 Workshop, seminar, course or exhibition
    • 1 Editorial activity
    • 1 Keynote talk
    • 1 Plenary talk

    Developments in the assessment of sleep and circadian rhythms

    Sebastiaan Overeem (Organiser)
    10 May 2019

    Activity: Participating in or organising an event typesWorkshop, seminar, course or exhibitionScientific

    Waarom kan je je niet herinneren dat je in slaap bent gevallen?

    Sebastiaan Overeem (Speaker)
    2 May 2019

    Activity: Talk or presentation typesKeynote talkPopular

    A Somnologist's Dream

    Sebastiaan Overeem (Speaker)
    19 Jan 2018

    Activity: Talk or presentation typesPlenary talkProfessional

    Sleep Medicine Reviews (Journal)

    Sebastiaan Overeem (Editorial board member)
    2012 → …

    Activity: Publication peer-review and editorial work typesEditorial activityScientific

    Press / Media

    Apneu beu

    Sebastiaan Overeem


    1 Media contribution

    Press/Media: Expert Comment

    Voor opsporen slaapapneu is [dit] wellicht niet meer nodig

    Sebastiaan Overeem


    1 Media contribution

    Press/Media: Expert Comment

    Detecting sleep apnea in your own bed

    Sebastiaan Overeem


    2 items of Media coverage

    Press/Media: Expert Comment

    Slaapapneu opsporen vanuit je eigen bed

    Sebastiaan Overeem


    1 Media contribution

    Press/Media: Expert Comment

    Student theses

    Design for sleep paralysis

    Author: Matthijsse, D., 2016

    Supervisor: Hu, J. (Supervisor 1), Markopoulos, P. (Supervisor 2), Overeem, S. (Supervisor 2), Tao, L. (Supervisor 2) & de Wit, J. (Supervisor 2)

    Student thesis: Bachelor