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Personal profile

Research profile

Sebastiaan Overeem is Full Professor in the Signal Processing Systems group (Department of Electrical Engineering) and in the Future Everyday group (Department of Industrial Design). He is a clinical somnologist and a neuroscientist, holding the chair Intelligent Systems for Sleep Disorders. He focuses on the development, validation and implementation of new diagnostic methods for sleep and sleep disorders.

Overeem has a broad interest and experience in the field of sleep medicine.  One focus over the last 15 years has been on narcolepsy, including the neurophysiology of cataplexy and the biology of the hypocretin system. The hypocretin-system formed the initial connecting link to sleep in Parkinson’s disease, when it was shown that hypocretin defects are present in Parkinson’s as a cause of sleep disturbances. This work led to a research line on sleep disorders in neurodegenerative disease, which is how Overeem was first appointed researcher at Eindhoven University of Technology (TU/e).

Within the framework of the Eindhoven MedTech Innovation Center, Overeem is participating in a various research efforts aiming to improve the diagnosis of sleep disorders, by developing and validating new non-obtrusive measurement modalities. Importantly, besides objective measures, the assessement of subjective sleep experience and symptoms is an integral topic of research.

His clinical work as a sleep medicine specialist takes place at the Center for Sleep Medicine Kempenhaeghe.

Academic background

Sebastiaan Overeem holds a PhD (2003) and MD (2004) from Leiden University. Part of his theis work took place at the Center for Narcolepsy Research at Stanford University. After graduating, he worked as Assistant Professor in the Department of Neurology at Radboud University Medical Center from 2005 to 2015. In 2008, he took up the position of somnologist at expertise center Kempenhaeghe. Overeem joined Eindhoven University of Technology (TU/e) as Senior Researcher in 2015 and was appointed professor in 2017.


“Technological developments in the area of sleep diagnostics are essential to improve the care for patients with sleep disorders, diseases with a tremendous impact on quality of life.”

External positions

somnologist, Kempenhaeghe

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

Narcolepsy Medicine & Life Sciences
Parkinson Disease Medicine & Life Sciences
Sleep Medicine & Life Sciences
Cataplexy Medicine & Life Sciences
Sodium Oxybate Medicine & Life Sciences
Gait Medicine & Life Sciences
Sleep Initiation and Maintenance Disorders Medicine & Life Sciences
Polysomnography Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2009 2018

A digital sleep restriction system for insomnia therapy based on sleep window shift negotiation

Erten-Uyumaz, B., Overeem, S., Feijs, L., Rama, M. D. & Hu, J., 26 Jun 2018, Proceedings of the 11th PErvasive Technologies Related to Assistive Environments Conference, PETRA 2018. Association for Computing Machinery, Inc, p. 58-61 4 p.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review


Autonomic cardiac activity in adults with short and long sleep onset latency

Nano, M. M., Fonseca, P., Overeem, S., Vullings, R. & Aarts, R. M., 26 Oct 2018, 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018. Piscataway: Institute of Electrical and Electronics Engineers (IEEE), p. 1448-1451 4 p. 8512534

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Healthy Volunteers
Sleep Stages

Conceptions of sleep experience: a layman perspective

Goelema, M. S., de Bruijn, R., Overeem, S., Møst, E., Haakma, R. & Markopoulos, P., 18 Jul 2018, In : AMAS Lecture Notes. 11, 1, 5 p., 494

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Data visualization

Enhanced food-related responses in the ventral medial prefrontal cortex in narcolepsy type 1

van Holst, R. J., Janssen, L. K., van Mierlo, P., Jan Lammers, G., Cools, R., Overeem, S. & Aarts, E., 1 Dec 2018, In : Scientific Reports. 8, 1, 12 p., 16391

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Prefrontal Cortex
Executive Function

Exploring the clinical features of narcolepsy type 1 versus narcolepsy type 2 from European Narcolepsy Network database with machine learning

Zhang, Z., Mayer, G., Dauvilliers, Y., Plazzi, G., Pizza, F., Fronczek, R., Santamaria, J., Partinen, M., Overeem, S., Peraita-Adrados, R., Da Silva, A. M., Sonka, K., Rio-Villegas, R. D., Heinzer, R., Wierzbicka, A., Young, P., Högl, B., Bassetti, C. L., Manconi, M., Feketeova, E. & 17 othersMathis, J., Paiva, T., Canellas, F., Lecendreux, M., Baumann, C. R., Barateau, L., Pesenti, C., Antelmi, E., Gaig, C., Iranzo, A., Lillo-Triguero, L., Medrano-Martínez, P., Haba-Rubio, J., Gorban, C., Luca, G., Lammers, G. J. & Khatami, R., 13 Jul 2018, In : Scientific Reports. 8, 1, p. 11 10628

Research output: Contribution to journalArticleAcademicpeer-review

Open Access


The power of a nap: sleep benefit in Parkinson’s Disease

Sebastiaan Overeem (Recipient), 2011

Recognition: NWOVidiScientific

Activities 2012 2018

  • 1 Editorial activity
  • 1 Plenary talk

A Somnologist's Dream

Sebastiaan Overeem (Speaker)
19 Jan 2018

Activity: Talk or presentation typesPlenary talkProfessional

Sleep Medicine Reviews (Journal)

Sebastiaan Overeem (Editorial board member)
2012 → …

Activity: Publication peer-review and editorial work typesEditorial activityScientific

Press / Media

Technische snufjes tegen slecht slapen.

Sebastiaan Overeem


1 item of media coverage

Press/Media: Public Engagement Activities

Slapen met een app.

Sebastiaan Overeem


1 item of media coverage

Press/Media: Public Engagement Activities

Don't take changing the clocks too lightly

Yvonne de Kort & Sebastiaan Overeem


1 media contribution

Press/Media: Expert Comment


Sebastiaan Overeem


1 media contribution

Press/Media: Public Engagement Activities

Mensen met een slaapstoornis hebben niks aan gadgets.

Sebastiaan Overeem


1 item of media coverage

Press/Media: Public Engagement Activities

Student theses

Design for sleep paralysis

Author: Matthijsse, D., 2016

Supervisor: Hu, J. (Supervisor 1), Markopoulos, P. (Supervisor 2), Overeem, S. (Supervisor 2), Tao, L. (Supervisor 2) & de Wit, J. (Supervisor 2)

Student thesis: Bachelor