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Research Output 2007 2020

2020
7 Downloads (Pure)
Open Access
File
Tissue Engineering
Tissue engineering
Scaffolds
Tissue
Gastrin-Secreting Cells
2019
11 Downloads (Pure)

A computational model to predict cell traction-mediated prestretch in the mitral valve

van Kelle, M. A. J., Rausch, M. K., Kuhl, E. & Loerakker, S., 18 Nov 2019, In : Computer Methods in Biomechanics and Biomedical Engineering. 22, 15, p. 1174-1185 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Tissue
Actins
Structural properties
Anisotropy
Fibers
4 Downloads (Pure)

Biomechanics and modeling of tissue-engineered heart valves

Ristori, T., van Kelle, A. J. M., Baaijens, F. & Loerakker, S., 9 Apr 2019, Advances in heart valve biomechanics: valvular physiology, mechanobiology, and bioengineering. Sacks, M. & Liao, J. (eds.). Cham: Springer, p. 413-446 34 p.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Biomechanics
Tissue engineering
Tissue
Collagen
Heart valve prostheses
1 Citation (Scopus)
30 Downloads (Pure)

Increased cell traction-induced prestress in dynamically cultured microtissues

van Kelle, M. A. J., Khalil, N., Foolen, J., Loerakker, S. & Bouten, C. V. C., 12 Mar 2019, In : Frontiers in Bioengineering and Biotechnology. 7, 11 p., 41.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
8 Downloads (Pure)

Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress

van Engeland, N. C. A., Suarez Rodriguez, F., Rivero-Müller, A., Ristori, T., Duran, C. L., Stassen, O. M. J. A., Antfolk, D., Driessen, R. C. H., Ruohonen, S., Ruohonen, S. T., Nuutinen, S., Savontaus, E., Loerakker, S., Bayless, K. J., Sjöqvist, M., Bouten, C. V. C., Eriksson, J. E. & Sahlgren, C. M., 27 Aug 2019, In : Scientific Reports. 9, 1, 14 p., 12415.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Vimentin
Hemodynamics
Vascular Smooth Muscle
Transcriptional Activation
Smooth Muscle Myocytes
2018
22 Citations (Scopus)
16 Downloads (Pure)

Computational modeling guides tissue-engineered heart valve design for long-term in vivo performance in a translational sheep model

Emmert, M. Y., Schmitt, B. A., Loerakker, S., Sanders, B., Spriestersbach, H., Fioretta, E. S., Bruder, L., Brakmann, K., Motta, S. E., Lintas, V., Dijkman, P. E., Frese, L., Berger, F., Baaijens, F. P. T. & Hoerstrup, S. P., 9 May 2018, In : Science Translational Medicine. 10, 440, 13 p., eaan4587.

Research output: Contribution to journalArticleAcademicpeer-review

Heart Valves
Sheep
Tissue Engineering
Bioengineering
Heart Valve Prosthesis
57 Downloads (Pure)

Emergence of a geometrical and mechanical equilibrium in tissue-engineered heart valves?

van Kelle, A. J., Janssen - van den Broek, W. J. T., Lopata, R. G. P., Loerakker, S. & Bouten, C. V. C., 12 Apr 2018. 1 p.

Research output: Contribution to conferenceAbstract

Open Access
File
5 Citations (Scopus)
57 Downloads (Pure)

Growth and remodeling play opposing roles during postnatal human heart valve development

Oomen, P. J. A., Holland, M. A., Bouten, C. V. C., Kuhl, E. & Loerakker, S., 19 Jan 2018, In : Scientific Reports. 8, p. 1-13 13 p., 1235.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
heart valves
homeostasis
adult development
postnatal development
tissues
1 Citation (Scopus)
5 Downloads (Pure)

Initial scaffold thickness affects the emergence of a geometrical and mechanical equilibrium in engineered cardiovascular tissues

van Kelle, M. A. J., Oomen, P. J. A., Janssen-van den Broek, W. J. T., Lopata, R. G. P., Loerakker, S. & Bouten, C. V. C., 14 Nov 2018, In : Journal of Royal Society Interface. 15, 148, 12 p., 20180359.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Scaffolds
Tissue
Tissue Engineering
Tissue engineering
Polycaprolactone
3 Citations (Scopus)
68 Downloads (Pure)

Intrinsic cell stress is independent of organization in engineered cell sheets

van Loosdregt, I. A. E. W., Dekker, S., Alford, P. W., Oomens, C. W. J., Loerakker, S. & Bouten, C. V. C., 1 Jun 2018, In : Cardiovascular Engineering and Technology. 9, 2, p. 181-192 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Monolayers
Tissue
Myofibroblasts
Cell Count
Heart Valves
7 Citations (Scopus)
41 Downloads (Pure)

Mechanosensitivity of Jagged–Notch signaling can induce a switch-type behavior in vascular homeostasis

Loerakker, S., Stassen, O. M. J. A., ter Huurne, F. M., Boareto, M., Bouten, C. V. C. & Sahlgren, C. M., 17 Apr 2018, In : Proceedings of the National Academy of Sciences of the United States of America (PNAS). 115, 16, p. E3682-E3691 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Blood Vessels
Homeostasis
Vascular Smooth Muscle
Smooth Muscle Myocytes
Hemodynamics
3 Citations (Scopus)
51 Downloads (Pure)

Modelling the combined effects of collagen and cyclic strain on cellular orientation in collagenous tissues

Ristori, T., Notermans, T. M. W., Foolen, J., Kurniawan, N. A., Bouten, C. V. C., Baaijens, F. P. T. & Loerakker, S., 1 Dec 2018, In : Scientific Reports. 8, 1, 14 p., 8518.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Collagen
Heart Valves
Cues
Arteries
Gels
2 Citations (Scopus)
44 Downloads (Pure)

Predicting and understanding collagen remodeling in human native heart valves during early development

Ristori, T., Bouten, C. V. C., Baaijens, F. P. T. & Loerakker, S., 15 Oct 2018, In : Acta Biomaterialia. 80, p. 203-216

Research output: Contribution to journalArticleAcademicpeer-review

File
Heart Valves
Collagen
Bearings (structural)
Fibers
Pediatrics
3 Citations (Scopus)
1 Downloads (Pure)

Strain mediated enzymatic degradation of arterial tissue: Insights into the role of the non-collagenous tissue matrix and collagen crimp

Gaul, R. T., Nolan, D. R., Ristori, T., Bouten, C. V. C., Loerakker, S. & Lally, C., 1 Sep 2018, In : Acta Biomaterialia. 77, p. 301-310

Research output: Contribution to journalArticleAcademicpeer-review

Collagen
Tissue
Degradation
Fibers
Bearings (structural)
5 Downloads (Pure)
File
Stress Fibers
Vimentin
Knockout Mice
Fibroblasts
Focal Adhesions
12 Citations (Scopus)
71 Downloads (Pure)

Tissue alignment enhances remodeling potential of tendon-derived cells - lessons from a novel microtissue model of tendon scarring

Foolen, J., Wunderli, S. L., Loerakker, S. & Snedeker, J. G., Jan 2018, In : Matrix Biology. 65, p. 14-29 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Tendons
Cicatrix
Tendinopathy
Extracellular Matrix
Matrix Metalloproteinases
2017

A biologically motivated computational model to explain anisotropic prestretch in the mitral valve

van Kelle, A. J., Rausch, M., Bouten, C. V. C., Kuhl, E. & Loerakker, S., 2 Jul 2017.

Research output: Contribution to conferenceAbstract

5 Citations (Scopus)
104 Downloads (Pure)

A bioreactor to identify the driving mechanical stimuli of tissue growth and remodeling

van Kelle, A. J., Oomen, P. J. A., Bulsink, J. A., Janssen - van den Broek, W. J. T., Lopata, R. G. P., Rutten, M. C. M., Loerakker, S. & Bouten, C. V. C., 1 Jun 2017, In : Tissue Engineering. Part C: Methods. 23, 6, p. 377-387 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Bioreactors
Tissue
Growth
Mechanical testing
Mechanical Phenomena

A novel bioreactor to study the driving mechanical stimuli of tissue growth and remodeling

van Kelle, A. J., Oomen, P. J. A., Janssen - van den Broek, W. J. T., Lopata, R. G. P., Rutten, M. C. M., Loerakker, S. & Bouten, C. V. C., 21 Jun 2017.

Research output: Contribution to conferenceAbstract

3 Citations (Scopus)
62 Downloads (Pure)

Lmna knockout mouse embryonic fibroblasts are less contractile than their wild-type counterparts

van Loosdregt, I. A. E. W., Kamps, M. A. F., Oomens, C. W. J., Loerakker, S., Broers, J. L. V. & Bouten, C. V. C., 1 Aug 2017, In : Integrative Biology. 9, 8, p. 709-721 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Stress Fibers
Fibroblasts
Knockout Mice
Actins
Nuclear Lamina
3 Citations (Scopus)
131 Downloads (Pure)

Nondestructive mechanical characterization of developing biological tissues using inflation testing

Oomen, P. J. A., van Kelle, A. J., Oomens, C. W. J., Bouten, C. V. C. & Loerakker, S., 5 Jul 2017, In : Journal of the Mechanical Behavior of Biomedical Materials. 74, p. 438-447 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Tissue
Testing
Mechanical properties
Tissue culture
Mechanical testing
2016
19 Citations (Scopus)
172 Downloads (Pure)
Open Access
File
Collagen
Compaction
Tissue
Blood pressure
Tissue engineering
24 Citations (Scopus)
142 Downloads (Pure)

Age-dependent changes of stress and strain in the human heart valve and their relation with collagen remodeling

Oomen, P. J. A., Loerakker, S., Van Geemen, D., Neggers, J., Goumans, M. J. T. H., van den Bogaerdt, A. J., Bogers, A. J. J. C., Bouten, C. V. C. & Baaijens, F. P. T., 1 Jan 2016, In : Acta Biomaterialia. 29, p. 161-169 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Heart Valves
Collagen
Aortic Valve
Pulmonary Valve
Tissue Engineering
6 Citations (Scopus)
55 Downloads (Pure)

Efficient computational simulation of actin stress fiber remodeling

Ristori, T., Obbink-Huizer, C., Oomens, C. W. J., Baaijens, F. P. T. & Loerakker, S., 28 Jan 2016, In : Computer Methods in Biomechanics and Biomedical Engineering. 19, 12, p. 1347-1358 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Actins
Fibers
Collagen
Tissue
Costs
20 Citations (Scopus)
106 Downloads (Pure)

Improved geometry of decellularized tissue engineered heart valves to prevent leaflet retraction

Sanders, B., Loerakker, S., Fioretta, E. S., Bax, J. P., Driessen - Mol, A., Hoerstrup, S. & Baaijens, F. P. T., Apr 2016, In : Annals of Biomedical Engineering. 44, 4, p. 1061-1071 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Tissue
Geometry
Bioreactors
Cell culture
Collagen
75 Downloads (Pure)
Open Access
File
6 Citations (Scopus)
46 Downloads (Pure)

Prediction of cell alignment on cyclically strained grooved substrates

Ristori, T., Vigliotti, A., Baaijens, F. P. T., Loerakker, S. & Deshpande, V. S., 15 Nov 2016, In : Biophysical Journal. 111, 10, p. 2274-2285 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Biophysical Phenomena
Focal Adhesions
Cytoskeleton
Cues
Cultured Cells
35 Downloads (Pure)

Remodeling of tissue-engineered heart valves during a one-year follow-up period in sheep : a computational-experimental analysis

Loerakker, S., Sanders, B., Schmitt, B., Dijkman, P. E., Spriestersbach, H., Driessen-Mol, A., Fioretta, E. S., Bartosch, M., Frese, L., Hoerstrup, S. P., Berger, F. & Baaijens, F. P. T., 2016, In : Cardiology. 134, 2, p. 147 1 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
2015
39 Downloads (Pure)
cells
tissues
28 Downloads (Pure)

Controlling tissue engineered heart valve geometry by using predefined inserts during culture

Sanders, B., Loerakker, S., Driessen - Mol, A., Hoerstrup, S. & Baaijens, F. P. T., 2 Apr 2015, IPC No. A61F 2/24, Patent No. WO2015044190, Priority date 27 Sep 2013

Research output: PatentPatent publication

Open Access
File
heart valves
tissue culture
tissues
geometry

First successful one-year follow up of decellularized tissue engineered heart valves in sheep

Sanders, B., Schmitt, B., Loerakker, S., Spriestersbach, H., Driessen-Mol, A., Fioretta, E., Dijkman, P., Bartosch, M., Frese, L., Berger, F., Baaijens, F. & Hoerstrup, S., 1 Sep 2015, In : Tissue engineering. Part A. 21, p. S227-S227

Research output: Contribution to journalMeeting AbstractAcademic

62 Citations (Scopus)
10 Downloads (Pure)

Pressure induced deep tissue injury explained

Oomens, C. W. J., Bader, D. L., Loerakker, S. & Baaijens, F. P. T., Feb 2015, In : Annals of Biomedical Engineering. 43, 2, p. 297-305 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Animals
Tissue
Pressure
Tissue culture
Pressure Ulcer
2014
22 Citations (Scopus)
7 Downloads (Pure)

A physically motivated constitutive model for cell-mediated compaction and collagen remodeling in soft tissues

Loerakker, S., Obbink - Huizer, C. & Baaijens, F. P. T., 2014, In : Biomechanics and Modeling in Mechanobiology. 13, 5, p. 985-1001 17 p.

Research output: Contribution to journalArticleAcademicpeer-review

Remodeling
Collagen
Soft Tissue
Compaction
Constitutive Model
27 Citations (Scopus)
1 Downloads (Pure)

Computational model predicts cell orientation in response to a range of mechanical stimuli

Obbink - Huizer, C., Oomens, C. W. J., Loerakker, S., Foolen, J., Bouten, C. V. C. & Baaijens, F. P. T., 2014, In : Biomechanics and Modeling in Mechanobiology. 13, 1, p. 227-236 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Stress Fibers
Computational Model
Fiber
Predict
Fibers
9 Downloads (Pure)

First tissue-engineered heart valve 1-year follow-up in sheep

Sanders, B., Loerakker, S., Schmitt, B., Spriestersbach, H., Fioretta, E. S., Bartosch, M., Dijkman, P. E., Frese, L., Driessen-Mol, A., Hoerstrup, S. P. & Baaijens, F. P. T., 2014.

Research output: Contribution to conferencePoster

97 Downloads (Pure)
Open Access
File
26 Citations (Scopus)
99 Downloads (Pure)

The influence of matrix (an)isotropy on cardiomyocyte contraction in engineered cardiac microtissues

Spreeuwel, van, A. C. C., Bax, N. A. M., Bastiaens, A. J., Foolen, J., Loerakker, S., Borochin, M. A., Schaft, van der, D. W. J., Chen, C. S., Baaijens, F. P. T. & Bouten, C. V. C., 2014, In : Integrative Biology. 6, 4, p. 422-429 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Cardiac Myocytes
Heart Diseases
Sarcomeres
Cell Shape
Hydrogel
21 Downloads (Pure)

Unraveling collagen remodelling in human native heart valves

Oomen, P. J. A., Loerakker, S., Bouten, C. V. C. & Baaijens, F. P. T., 2014.

Research output: Contribution to conferencePoster

2013
7 Downloads (Pure)

A new model system to measure tissue stress and retraction

Loosdregt, van, I. A. E. W., Loerakker, S., Driessen - Mol, A. & Baaijens, F. P. T., 2013.

Research output: Contribution to conferencePoster

Computational modeling of cell orientation in 3D micro-constructs

Obbink-Huizer, C., Oomens, C. W. J., Loerakker, S., Foolen, J., Bouten, C. V. C. & Baaijens, F. P. T., 1 Dec 2013, ASME 2013 Summer Bioengineering Conference, SBC 2013. Vol. 1 A. 2 p. SBC2013-14252

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Stress Fibers
Fibers
Silicones
Tissue Engineering
Actins
2 Downloads (Pure)

Controlling valve geometry during culture

Sanders, B., Loerakker, S., Driessen - Mol, A., Hoerstrup, S. P. & Baaijens, F. P. T., 2013.

Research output: Contribution to conferencePoster

35 Citations (Scopus)
4 Downloads (Pure)

Effects of valve geometry and tissue anisotropy on the radial stretch and coaptation area of tissue-engineered heart valves

Loerakker, S., Argento, G., Oomens, C. W. J. & Baaijens, F. P. T., 2013, In : Journal of Biomechanics. 46, 11, p. 1792-1800

Research output: Contribution to journalArticleAcademicpeer-review

Heart Valves
Anisotropy
Tissue
Geometry
Blood Pressure

Effects of valve geometry and tissue anisotropy on the radial stretch and coaptation area of tissue-engineered heart valves

Loerakker, S., Argento, G., Oomens, C. W. J. & Baaijens, F. P. T., 2013, ASME 2013 Summer Bioengineering Conference, SBC 2013, 26-29 June 2013, Sunriver, Oregon. American Society of Mechanical Engineers, p. 1-2 SBC2013-14234

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Heart Valves
Anisotropy
Tissue
Geometry
Tissue Engineering
16 Citations (Scopus)
3 Downloads (Pure)

How does muscle stiffness affect the internal deformations within the soft tissue layers of the buttocks under constant loading?

Loerakker, S., Solis, L. R., Bader, D. L., Baaijens, F. P. T., Mushahwar, V. K. & Oomens, C. W. J., 2013, In : Computer Methods in Biomechanics and Biomedical Engineering. 16, 5, p. 520-529

Research output: Contribution to journalArticleAcademicpeer-review

Muscle
Stiffness
Tissue
Shear strain
Oils and fats
4 Downloads (Pure)

Influence of anisotropy on cardiomyocyte contraction in engineered microtissues

Spreeuwel, van, A. C. C., Bax, N. A. M., Bastiaens, A. J., Foolen, J., Loerakker, S., Borochin, M. A., Schaft, van der, D. W. J., Chen, C. S., Baaijens, F. P. T. & Bouten, C. V. C., 2013.

Research output: Contribution to conferencePoster

68 Downloads (Pure)

Modeling cell-mediated compaction and collagen remodeling in tissue-engineered heart valves

Loerakker, S., Obbink - Huizer, C. & Baaijens, F. P. T., 2013.

Research output: Contribution to conferencePoster

Open Access
File
9 Citations (Scopus)
6 Downloads (Pure)
Muscle
Tissue
Animals
Experiments
Skin
2012
1 Downloads (Pure)