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Research Output 2007 2019

2019

A computational model to predict cell traction-mediated prestretch in the mitral valve

van Kelle, M. A. J., Rausch, M. K., Kuhl, E. & Loerakker, S., 19 Aug 2019, In : Computer Methods in Biomechanics and Biomedical Engineering.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Tissue
Actins
Structural properties
Anisotropy
Fibers

Biomechanics and modeling of tissue-engineered heart valves

Ristori, T., van Kelle, A. J. M., Baaijens, F. & Loerakker, S., 9 Apr 2019, Advances in heart valve biomechanics: valvular physiology, mechanobiology, and bioengineering. Sacks, M. & Liao, J. (eds.). Cham: Springer, p. 413-446 34 p.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Biomechanics
Tissue engineering
Tissue
Collagen
Heart valve prostheses
1 Citation (Scopus)

Increased cell traction-induced prestress in dynamically cultured microtissues

van Kelle, M. A. J., Khalil, N., Foolen, J., Loerakker, S. & Bouten, C. V. C., 12 Mar 2019, In : Frontiers in Bioengineering and Biotechnology. 7, 11 p., 41

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File

Mechanically driven adaptation in engineered cardiovascular tissues

van Kelle, A. J., 31 Jan 2019, Eindhoven: Technische Universiteit Eindhoven. 134 p.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)Academic

Heart Valves
Blood Vessels

Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress

van Engeland, N. C. A., Suarez Rodriguez, F., Rivero-Müller, A., Ristori, T., Duran, C. L., Stassen, O. M. J. A., Antfolk, D., Driessen, R. C. H., Ruohonen, S., Ruohonen, S. T., Nuutinen, S., Savontaus, E., Loerakker, S., Bayless, K. J., Sjöqvist, M., Bouten, C. V. C., Eriksson, J. E. & Sahlgren, C. M., 27 Aug 2019, In : Scientific Reports. 9, 1, 14 p., 12415

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Vimentin
Hemodynamics
Vascular Smooth Muscle
Transcriptional Activation
Smooth Muscle Myocytes
2018

Computational analysis of cell-mediated remodeling of collagenous tissues

Ristori, T., 5 Mar 2018, Eindhoven: Technische Universiteit Eindhoven. 177 p.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)Academic

Open Access
File
13 Citations (Scopus)

Computational modeling guides tissue-engineered heart valve design for long-term in vivo performance in a translational sheep model

Emmert, M. Y., Schmitt, B. A., Loerakker, S., Sanders, B., Spriestersbach, H., Fioretta, E. S., Bruder, L., Brakmann, K., Motta, S. E., Lintas, V., Dijkman, P. E., Frese, L., Berger, F., Baaijens, F. P. T. & Hoerstrup, S. P., 9 May 2018, In : Science Translational Medicine. 10, 440, 13 p., eaan4587

Research output: Contribution to journalArticleAcademicpeer-review

Heart Valves
Sheep
Tissue Engineering
Bioengineering
Heart Valve Prosthesis

Emergence of a geometrical and mechanical equilibrium in tissue-engineered heart valves?

van Kelle, A. J., Janssen - van den Broek, W. J. T., Lopata, R. G. P., Loerakker, S. & Bouten, C. V. C., 12 Apr 2018 1 p.

Research output: Contribution to conferenceAbstractAcademic

Open Access
File
3 Citations (Scopus)

Growth and remodeling play opposing roles during postnatal human heart valve development

Oomen, P. J. A., Holland, M. A., Bouten, C. V. C., Kuhl, E. & Loerakker, S., 19 Jan 2018, In : Scientific Reports. 8, p. 1-13 13 p., 1235

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
heart valves
homeostasis
adult development
postnatal development
tissues

Initial scaffold thickness affects the emergence of a geometrical and mechanical equilibrium in engineered cardiovascular tissues

van Kelle, M. A. J., Oomen, P. J. A., Janssen-van den Broek, W. J. T., Lopata, R. G. P., Loerakker, S. & Bouten, C. V. C., 14 Nov 2018, In : Journal of Royal Society Interface. 15, 148, 12 p., 20180359

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Scaffolds
Tissue
Tissue Engineering
Tissue engineering
Polycaprolactone
3 Citations (Scopus)

Intrinsic cell stress is independent of organization in engineered cell sheets

van Loosdregt, I. A. E. W., Dekker, S., Alford, P. W., Oomens, C. W. J., Loerakker, S. & Bouten, C. V. C., 1 Jun 2018, In : Cardiovascular Engineering and Technology. 9, 2, p. 181-192 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Monolayers
Tissue
Myofibroblasts
Cell Count
Heart Valves

Mechanics of growth and remodeling in native and engineered cardiovascular tissues

Oomen, P. J. A., 15 Oct 2018, Eindhoven: Technische Universiteit Eindhoven. 144 p.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)Academic

Open Access
File
Mechanics
Growth
4 Citations (Scopus)

Mechanosensitivity of Jagged–Notch signaling can induce a switch-type behavior in vascular homeostasis

Loerakker, S., Stassen, O. M. J. A., ter Huurne, F. M., Boareto, M., Bouten, C. V. C. & Sahlgren, C. M., 17 Apr 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 16, p. E3682-E3691 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Blood Vessels
Homeostasis
Vascular Smooth Muscle
Smooth Muscle Myocytes
Hemodynamics
1 Citation (Scopus)

Modelling the combined effects of collagen and cyclic strain on cellular orientation in collagenous tissues

Ristori, T., Notermans, T. M. W., Foolen, J., Kurniawan, N. A., Bouten, C. V. C., Baaijens, F. P. T. & Loerakker, S., 1 Dec 2018, In : Scientific Reports. 8, 1, 14 p., 8518

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Collagen
Heart Valves
Cues
Arteries
Gels

Predicting and understanding collagen remodeling in human native heart valves during early development

Ristori, T., Bouten, C. V. C., Baaijens, F. P. T. & Loerakker, S., 15 Oct 2018, In : Acta Biomaterialia. 80, p. 203-216

Research output: Contribution to journalArticleAcademicpeer-review

File
Heart Valves
Collagen
Bearings (structural)
Fibers
Pediatrics

Quantifying the effect of structural manipulations on cellular stress generation

van Loosdregt, I. A. E. W., 23 Jan 2018, Eindhoven: Technische Universiteit Eindhoven. 113 p.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)Academic

Open Access
File
2 Citations (Scopus)

Strain mediated enzymatic degradation of arterial tissue: Insights into the role of the non-collagenous tissue matrix and collagen crimp

Gaul, R. T., Nolan, D. R., Ristori, T., Bouten, C. V. C., Loerakker, S. & Lally, C., 1 Sep 2018, In : Acta Biomaterialia. 77, p. 301-310

Research output: Contribution to journalArticleAcademicpeer-review

Collagen
Tissue
Degradation
Fibers
Bearings (structural)
Stress Fibers
Vimentin
Knockout Mice
Fibroblasts
Focal Adhesions
9 Citations (Scopus)

Tissue alignment enhances remodeling potential of tendon-derived cells - lessons from a novel microtissue model of tendon scarring

Foolen, J., Wunderli, S. L., Loerakker, S. & Snedeker, J. G., Jan 2018, In : Matrix Biology. 65, p. 14-29 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Tendons
Cicatrix
Tendinopathy
Extracellular Matrix
Matrix Metalloproteinases
2017

A biologically motivated computational model to explain anisotropic prestretch in the mitral valve

van Kelle, A. J., Rausch, M., Bouten, C. V. C., Kuhl, E. & Loerakker, S., 2 Jul 2017

Research output: Contribution to conferenceAbstractAcademic

3 Citations (Scopus)

A bioreactor to identify the driving mechanical stimuli of tissue growth and remodeling

van Kelle, A. J., Oomen, P. J. A., Bulsink, J. A., Janssen - van den Broek, W. J. T., Lopata, R. G. P., Rutten, M. C. M., Loerakker, S. & Bouten, C. V. C., 1 Jun 2017, In : Tissue Engineering. Part C: Methods. 23, 6, p. 377-387 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Bioreactors
Tissue
Growth
Mechanical testing
Mechanical Phenomena

A novel bioreactor to study the driving mechanical stimuli of tissue growth and remodeling

van Kelle, A. J., Oomen, P. J. A., Janssen - van den Broek, W. J. T., Lopata, R. G. P., Rutten, M. C. M., Loerakker, S. & Bouten, C. V. C., 21 Jun 2017

Research output: Contribution to conferenceAbstractAcademic

3 Citations (Scopus)

Lmna knockout mouse embryonic fibroblasts are less contractile than their wild-type counterparts

van Loosdregt, I. A. E. W., Kamps, M. A. F., Oomens, C. W. J., Loerakker, S., Broers, J. L. V. & Bouten, C. V. C., 1 Aug 2017, In : Integrative Biology. 9, 8, p. 709-721 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Stress Fibers
Fibroblasts
Knockout Mice
Actins
Nuclear Lamina
3 Citations (Scopus)

Nondestructive mechanical characterization of developing biological tissues using inflation testing

Oomen, P. J. A., van Kelle, A. J., Oomens, C. W. J., Bouten, C. V. C. & Loerakker, S., 5 Jul 2017, In : Journal of the Mechanical Behavior of Biomedical Materials. 74, p. 438-447 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Tissue
Testing
Mechanical properties
Tissue culture
Mechanical testing
2016
16 Citations (Scopus)
Open Access
File
Collagen
Compaction
Tissue
Blood pressure
Tissue engineering
20 Citations (Scopus)

Age-dependent changes of stress and strain in the human heart valve and their relation with collagen remodeling

Oomen, P. J. A., Loerakker, S., Van Geemen, D., Neggers, J., Goumans, M. J. T. H., van den Bogaerdt, A. J., Bogers, A. J. J. C., Bouten, C. V. C. & Baaijens, F. P. T., 1 Jan 2016, In : Acta Biomaterialia. 29, p. 161-169 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Heart Valves
Collagen
Aortic Valve
Pulmonary Valve
Tissue Engineering

Computational design of stents for tissue-engineered heart valve replacement

Cabrera, M. S., 16 Nov 2016, Eindhoven: Technische Universiteit Eindhoven. 163 p.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)Academic

Open Access
File
5 Citations (Scopus)

Efficient computational simulation of actin stress fiber remodeling

Ristori, T., Obbink-Huizer, C., Oomens, C. W. J., Baaijens, F. P. T. & Loerakker, S., 28 Jan 2016, In : Computer Methods in Biomechanics and Biomedical Engineering. 19, 12, p. 1347-1358 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Actins
Fibers
Collagen
Tissue
Costs
18 Citations (Scopus)

Improved geometry of decellularized tissue engineered heart valves to prevent leaflet retraction

Sanders, B., Loerakker, S., Fioretta, E. S., Bax, J. P., Driessen - Mol, A., Hoerstrup, S. & Baaijens, F. P. T., Apr 2016, In : Annals of Biomedical Engineering. 44, 4, p. 1061-1071 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Tissue
Geometry
Bioreactors
Cell culture
Collagen

Lamin deficient cells are less contractile due to their disrupted cytoskeleton organization

van Loosdregt, I. A. E. W., Kamps, M. A. F., Oomens, C. W. J., Loerakker, S., Broers, J. L. V. & Bouten, C. V. C., 2016

Research output: Contribution to conferencePosterAcademic

Open Access
File
4 Citations (Scopus)

Prediction of cell alignment on cyclically strained grooved substrates

Ristori, T., Vigliotti, A., Baaijens, F. P. T., Loerakker, S. & Deshpande, V. S., 15 Nov 2016, In : Biophysical Journal. 111, 10, p. 2274-2285 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Biophysical Phenomena
Focal Adhesions
Cytoskeleton
Cues
Cultured Cells

Remodeling of tissue-engineered heart valves during a one-year follow-up period in sheep : a computational-experimental analysis

Loerakker, S., Sanders, B., Schmitt, B., Dijkman, P. E., Spriestersbach, H., Driessen-Mol, A., Fioretta, E. S., Bartosch, M., Frese, L., Hoerstrup, S. P., Berger, F. & Baaijens, F. P. T., 2016, In : Cardiology. 134, 2, p. 147 1 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
2015
cells
tissues

Controlling tissue engineered heart valve geometry by using predefined inserts during culture

Sanders, B., Loerakker, S., Driessen - Mol, A., Hoerstrup, S. & Baaijens, F. P. T., 2 Apr 2015, IPC No. A61F 2/24, Patent No. WO2015044190, Priority date 27 Sep 2013

Research output: PatentPatent publicationProfessional

Open Access
File
heart valves
tissue culture
tissues
geometry

First successful one-year follow up of decellularized tissue engineered heart valves in sheep

Sanders, B., Schmitt, B., Loerakker, S., Spriestersbach, H., Driessen-Mol, A., Fioretta, E., Dijkman, P., Bartosch, M., Frese, L., Berger, F., Baaijens, F. & Hoerstrup, S., 1 Sep 2015, In : Tissue engineering. Part A. 21, p. S227-S227

Research output: Contribution to journalMeeting AbstractAcademic

51 Citations (Scopus)

Pressure induced deep tissue injury explained

Oomens, C. W. J., Bader, D. L., Loerakker, S. & Baaijens, F. P. T., Feb 2015, In : Annals of Biomedical Engineering. 43, 2, p. 297-305 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Animals
Tissue
Pressure
Tissue culture
Pressure Ulcer
2014
20 Citations (Scopus)

A physically motivated constitutive model for cell-mediated compaction and collagen remodeling in soft tissues

Loerakker, S., Obbink - Huizer, C. & Baaijens, F. P. T., 2014, In : Biomechanics and Modeling in Mechanobiology. 13, 5, p. 985-1001 17 p.

Research output: Contribution to journalArticleAcademicpeer-review

Remodeling
Collagen
Soft Tissue
Compaction
Constitutive Model
26 Citations (Scopus)

Computational model predicts cell orientation in response to a range of mechanical stimuli

Obbink - Huizer, C., Oomens, C. W. J., Loerakker, S., Foolen, J., Bouten, C. V. C. & Baaijens, F. P. T., 2014, In : Biomechanics and Modeling in Mechanobiology. 13, 1, p. 227-236 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Stress Fibers
Computational Model
Fiber
Predict
Fibers

First tissue-engineered heart valve 1-year follow-up in sheep

Sanders, B., Loerakker, S., Schmitt, B., Spriestersbach, H., Fioretta, E. S., Bartosch, M., Dijkman, P. E., Frese, L., Driessen-Mol, A., Hoerstrup, S. P. & Baaijens, F. P. T., 2014

Research output: Contribution to conferencePosterAcademic

Solutions for preventing leaflet retraction in tissue-engineered heart valves

Loerakker, S., Sanders, B., Obbink - Huizer, C., Ristori, T., Hoerstrup, S. & Baaijens, F. P. T., 2014

Research output: Contribution to conferencePosterAcademic

Open Access
File
26 Citations (Scopus)

The influence of matrix (an)isotropy on cardiomyocyte contraction in engineered cardiac microtissues

Spreeuwel, van, A. C. C., Bax, N. A. M., Bastiaens, A. J., Foolen, J., Loerakker, S., Borochin, M. A., Schaft, van der, D. W. J., Chen, C. S., Baaijens, F. P. T. & Bouten, C. V. C., 2014, In : Integrative Biology. 6, 4, p. 422-429 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Cardiac Myocytes
Heart Diseases
Sarcomeres
Cell Shape
Hydrogel

Unraveling collagen remodelling in human native heart valves

Oomen, P. J. A., Loerakker, S., Bouten, C. V. C. & Baaijens, F. P. T., 2014

Research output: Contribution to conferencePosterAcademic

2013

A new model system to measure tissue stress and retraction

Loosdregt, van, I. A. E. W., Loerakker, S., Driessen - Mol, A. & Baaijens, F. P. T., 2013

Research output: Contribution to conferencePosterAcademic

Computational modeling of cell orientation in 3D micro-constructs

Obbink-Huizer, C., Oomens, C. W. J., Loerakker, S., Foolen, J., Bouten, C. V. C. & Baaijens, F. P. T., 1 Dec 2013, ASME 2013 Summer Bioengineering Conference, SBC 2013. Vol. 1 A, 2 p. SBC2013-14252

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Stress Fibers
Fibers
Silicones
Tissue Engineering
Actins

Controlling valve geometry during culture

Sanders, B., Loerakker, S., Driessen - Mol, A., Hoerstrup, S. P. & Baaijens, F. P. T., 2013

Research output: Contribution to conferencePosterAcademic

33 Citations (Scopus)

Effects of valve geometry and tissue anisotropy on the radial stretch and coaptation area of tissue-engineered heart valves

Loerakker, S., Argento, G., Oomens, C. W. J. & Baaijens, F. P. T., 2013, In : Journal of Biomechanics. 46, 11, p. 1792-1800

Research output: Contribution to journalArticleAcademicpeer-review

Heart Valves
Anisotropy
Tissue
Geometry
Blood Pressure

Effects of valve geometry and tissue anisotropy on the radial stretch and coaptation area of tissue-engineered heart valves

Loerakker, S., Argento, G., Oomens, C. W. J. & Baaijens, F. P. T., 2013, ASME 2013 Summer Bioengineering Conference, SBC 2013, 26-29 June 2013, Sunriver, Oregon. American Society of Mechanical Engineers, p. 1-2 SBC2013-14234

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Heart Valves
Anisotropy
Tissue
Geometry
Tissue Engineering
16 Citations (Scopus)
Muscle
Stiffness
Tissue
Shear strain
Oils and fats