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Research Output 2006 2019

  • 1096 Citations
  • 20 Article
  • 8 Review article
  • 1 Conference contribution
  • 1 Phd Thesis 4 Research NOT TU/e / Graduation NOT TU/e)
2019

Fusion-dependent formation of lipid nanoparticles containing macromolecular payloads

Kulkarni, J. A., Witzigmann, D., Leung, J., van der Meel, R., Zaifman, J., Darjuan, M. M., Grisch-Chan, H. M., Thöny, B., Tam, Y. Y. C. & Cullis, P. R., 14 May 2019, In : Nanoscale. 11, 18, p. 9023-9031 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Lipids
Fusion reactions
Nanoparticles
Polyethylene glycols
Gene therapy

Lipid nanoparticle technology for clinical translation of siRNA therapeutics

Kulkarni, J. A., Witzigmann, D., Chen, S., Cullis, P. R. & van der Meel, R., 9 Aug 2019, In : Accounts of Chemical Research.

Research output: Contribution to journalReview articleAcademicpeer-review

Small Interfering RNA
Nanoparticles
Lipids
Genes
Prealbumin
2018
12 Citations (Scopus)

Lipid nanoparticles enabling gene therapies: from concepts to clinical utility

Kulkarni, J. A., Cullis, P. R. & van der Meel, R., Jun 2018, In : Nucleic Acid Therapeutics. 28, 3, p. 146-157 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Genetic Therapy
Nanoparticles
Lipids
Small Interfering RNA
Clustered Regularly Interspaced Short Palindromic Repeats
10 Citations (Scopus)

On the formation and morphology of lipid nanoparticles containing Ionizable cationic lipids and siRNA

Kulkarni, J. A., Darjuan, M. M., Mercer, J. E., Chen, S., van der Meel, R., Thewalt, J. L., Tam, Y. Y. C. & Cullis, P. R., 22 May 2018, In : ACS Nano. 12, 5, p. 4787-4795 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Lipids
Small Interfering RNA
lipids
Nanoparticles
nanoparticles

State‐of‐the‐art design and rapid‐mixing production techniques of lipid nanoparticles for nucleic acid delivery

Evers, M. J. W., Kulkarni, J. A., van der Meel, R., Cullis, P. R., Vader, P. & Schiffelers, R. M., 26 Apr 2018, In : Small Methods. 2, 9, 20 p., 1700375

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
Nanoparticles
Nucleic Acids
Small Interfering RNA
Lipids
Cytoplasm
1 Citation (Scopus)

Translating nanomedicines: Thinking beyond materials? a young investigator's reply to 'The Novelty Bubble'

Witzigmann, D., Hak, S. & van der Meel, R., 28 Nov 2018, In : Journal of Controlled Release. 290, p. 138-140 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

Research Personnel
2017
30 Citations (Scopus)

Cancer nanomedicines: oversold or underappreciated?

van der Meel, R., Lammers, T. & Hennink, W. E., Jan 2017, In : Expert Opinion on Drug Delivery. 14, 1, p. 1-5 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Nanomedicine
Neoplasms
3 Citations (Scopus)

In situ gelling liquid crystalline system as local siRNA delivery system

Borgheti-Cardoso, L. N., Kooijmans, S. A. A., Fens, M. H. A. M., van der Meel, R., Vicentini, F. T. M. C., Fantini, M. C. A., Bentley, M. V. L. B. & Schiffelers, R. M., 1 May 2017, In : Molecular Pharmaceutics. 14, 5, p. 1681-1690 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Small Interfering RNA
Gels
Monoglycerides
Polyethyleneimine
Propylene Glycol
2016
5 Citations (Scopus)

Cetuximab treatment alters the content of extracellular vesicles released from tumor cells

van Dommelen, S. M., van der Meel, R., van Solinge, W. W., Coimbra, M., Vader, P. & Schiffelers, R. M., Apr 2016, In : Nanomedicine. 11, 8, p. 881-90 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Tumors
Cells
Biomarkers
Epidermal Growth Factor Receptor
Neoplasms
71 Citations (Scopus)

PEGylated and targeted extracellular vesicles display enhanced cell specificity and circulation time

Kooijmans, S. A. A., Fliervoet, L. A. L., van der Meel, R., Fens, M. H. A. M., Heijnen, H. F. G., van Bergen en Henegouwen, P. M. P., Vader, P. & Schiffelers, R. M., 28 Feb 2016, In : Journal of Controlled Release. 224, p. 77-85 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Single-Domain Antibodies
Epidermal Growth Factor Receptor
Extracellular Vesicles
Micelles
Phospholipids
11 Citations (Scopus)

The Niemann-Pick C1 inhibitor NP3.47 enhances gene silencing potency of lipid nanoparticles containing siRNA

Wang, H., Tam, Y. Y. C., Chen, S., Zaifman, J., van der Meel, R., Ciufolini, M. A. & Cullis, P. R., Dec 2016, In : Molecular Therapy. 24, 12, p. 2100-2108 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Gene Silencing
Nanoparticles
Small Interfering RNA
Lipids
Endosomes
2015
22 Citations (Scopus)

An in situ gelling liquid crystalline system based on monoglycerides and polyethylenimine for local delivery of siRNAs

Borgheti-Cardoso, L. N., Depieri, L. V., Kooijmans, S. A. A., Diniz, H., Calzzani, R. A. J., De Carvalho Vicentini, F. T. M., van der Meel, R., De Abreu Fantini, M. C., Iyomasa, M. M., Schiffelers, R. M. & Bentley, M. V. L. B., 10 Jul 2015, In : European Journal of Pharmaceutical Sciences. 74, p. 103-117 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Monoglycerides
Polyethyleneimine
Small Interfering RNA
Gels
Water
85 Citations (Scopus)

Complete regression of xenograft tumors upon targeted delivery of paclitaxel via ∏ - ∏ stacking stabilized polymeric micelles

Shi, Y., van der Meel, R., Theek, B., Oude Blenke, E., Pieters, E. H. E., Fens, M. H. A. M., Ehling, J., Schiffelers, R. M., Storm, G., Van Nostrum, C. F., Lammers, T. & Hennink, W. E., 28 Apr 2015, In : ACS Nano. 9, 4, p. 3740-3752 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Micelles
Paclitaxel
Heterografts
Tumors
regression analysis
2014
14 Citations (Scopus)

Capillary electrophoresis-based assessment of nanobody affinity and purity

Haselberg, R., Oliveira, S., van der Meel, R., Somsen, G. W. & de Jong, G. J., 25 Mar 2014, In : Analytica Chimica Acta. 818, p. 1-6 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Single-Domain Antibodies
Capillary electrophoresis
Capillary Electrophoresis
electrokinesis
Hexadimethrine Bromide
150 Citations (Scopus)

Extracellular vesicles as drug delivery systems: lessons from the liposome field

van der Meel, R., Fens, M. H. A. M., Vader, P., van Solinge, W. W., Eniola-Adefeso, O. & Schiffelers, R. M., 10 Dec 2014, In : Journal of Controlled Release. 195, p. 72-85 14 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Drug Delivery Systems
Liposomes
Nanomedicine
Drug Carriers
Pharmaceutical Preparations
33 Citations (Scopus)

Toward routine detection of extracellular vesicles in clinical samples

van der Meel, R., Krawczyk-Durka, M., van Solinge, W. W. & Schiffelers, R. M., Jun 2014, In : International Journal of Laboratory Hematology. 36, 3, p. 244-253 10 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
Standardization
Physiology
Biomarkers
Pathology
Cost effectiveness

Tumorgerichte nanobullets voor kankertherapie

van der Meel, R., 20 Jun 2014, In : Pharmaceutisch Weekblad. 149, 25, p. 90-99 10 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Nanomedicine
Neoplasms
Therapeutics
Pharmaceutical Preparations
Single-Domain Antibodies
2013
14 Citations (Scopus)

Inhibition of tumor growth by targeted anti-EGFR/IGF-1R nanobullets depends on efficient blocking of cell survival pathways

van der Meel, R., Oliveira, S., Altintas, I., Heukers, R., Pieters, E. H. E., van Bergen en Henegouwen, P. M. P., Storm, G., Hennink, W. E., Kok, R. J. & Schiffelers, R. M., 7 Oct 2013, In : Molecular Pharmaceutics. 10, 10, p. 3717-3727 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Nanomedicine
Epidermal Growth Factor Receptor
Cell Survival
Single-Domain Antibodies
Growth
230 Citations (Scopus)

Ligand-targeted particulate nanomedicines undergoing clinical evaluation: current status

van der Meel, R., Vehmeijer, L. J. C., Kok, R. J., Storm, G. & van Gaal, E. V. B., Oct 2013, In : Advanced Drug Delivery Reviews. 65, 10, p. 1284-1298 15 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Nanomedicine
Ligands
Pharmaceutical Preparations
Physiological Phenomena
Neoplasms
54 Citations (Scopus)

Nanobody-albumin nanoparticles (NANAPs) for the delivery of a multikinase inhibitor 17864 to EGFR overexpressing tumor cells

Altintas, I., Heukers, R., van der Meel, R., Lacombe, M., Amidi, M., van Bergen En Henegouwen, P. M. P., Hennink, W. E., Schiffelers, R. M. & Kok, R. J., 28 Jan 2013, In : Journal of Controlled Release. 165, 2, p. 110-118 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Single-Domain Antibodies
Epidermal Growth Factor Receptor
Nanoparticles
Albumins
Neoplasms

Targeted inhibition of tumor growth and angiogenesis

van der Meel, R., 2013, Utrecht: Utrecht University.

Research output: ThesisPhd Thesis 4 Research NOT TU/e / Graduation NOT TU/e)Academic

Open Access
2012
22 Citations (Scopus)

Targeted delivery of small interfering RNA to angiogenic endothelial cells with liposome-polycation-DNA particles

Vader, P., Crielaard, B. J., van Dommelen, S. M., van der Meel, R., Storm, G. & Schiffelers, R. M., 10 Jun 2012, In : Journal of Controlled Release. 160, 2, p. 211-216 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Liposomes
Small Interfering RNA
Endothelial Cells
Vascular Endothelial Growth Factor Receptor
DNA
54 Citations (Scopus)

Tumor-targeted nanobullets: anti-EGFR nanobody-liposomes loaded with anti-IGF-1R kinase inhibitor for cancer treatment

van der Meel, R., Oliveira, S., Altintas, I., Haselberg, R., van der Veeken, J., Roovers, R. C., van Bergen en Henegouwen, P. M. P., Storm, G., Hennink, W. E., Schiffelers, R. M. & Kok, R. J., 30 Apr 2012, In : Journal of Controlled Release. 159, 2, p. 281-289 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Single-Domain Antibodies
Somatomedin Receptors
Epidermal Growth Factor Receptor
Liposomes
Phosphotransferases
2011
23 Citations (Scopus)

Examining the role of Rac1 in tumor angiogenesis and growth: a clinically relevant RNAi-mediated approach

Vader, P., van der Meel, R., Symons, M. H., Fens, M. H. A. M., Pieters, E., Wilschut, K. J., Storm, G., Jarzabek, M., Gallagher, W. M., Schiffelers, R. M. & Byrne, A. T., Dec 2011, In : Angiogenesis. 14, 4, p. 457-66 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

RNA Interference
Vascular Endothelial Growth Factor A
Small Interfering RNA
Tumors
Endothelial cells
68 Citations (Scopus)

Nanobody-shell functionalized thermosensitive core-crosslinked polymeric micelles for active drug targeting

Talelli, M., Rijcken, C. J. F., Oliveira, S., van der Meel, R., van Bergen en Henegouwen, P. M. P., Lammers, T., van Nostrum, C. F., Storm, G. & Hennink, W. E., 30 Apr 2011, In : Journal of Controlled Release. 151, 2, p. 183-92 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Single-Domain Antibodies
Micelles
Drug Delivery Systems
Rhodamines
Muramidase
20 Citations (Scopus)

Reprint of: nanobody-shell functionalized thermosensitive core-crosslinked polymeric micelles for active drug targeting

Talelli, M., Rijcken, C. J. F., Oliveira, S., van der Meel, R., van Bergen en Henegouwen, P. M. P., Lammers, T., van Nostrum, C. F., Storm, G. & Hennink, W. E., 15 Jul 2011, In : Journal of Controlled Release. 153, 1, p. 93-102 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Single-Domain Antibodies
Micelles
Drug Delivery Systems
Rhodamines
Muramidase
43 Citations (Scopus)

The VEGF/Rho GTPase signalling pathway: a promising target for anti-angiogenic/anti-invasion therapy

van der Meel, R., Symons, M. H., Kudernatsch, R., Kok, R. J., Schiffelers, R. M., Storm, G., Gallagher, W. M. & Byrne, A. T., Mar 2011, In : Drug Discovery Today. 16, 5-6, p. 219-228 10 p.

Research output: Contribution to journalReview articleAcademicpeer-review

rho GTP-Binding Proteins
Vascular Endothelial Growth Factor A
Neoplasms
Therapeutics
Neoplasm Metastasis
2010
78 Citations (Scopus)

Downregulation of EGFR by a novel multivalent nanobody-liposome platform

Oliveira, S., Schiffelers, R. M., van der Veeken, J., van der Meel, R., Vongpromek, R., van Bergen en Henegouwen, P. M. P., Storm, G. & Roovers, R. C., 14 Jul 2010, In : Journal of Controlled Release. 145, 2, p. 165-175 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Single-Domain Antibodies
Epidermal Growth Factor Receptor
Liposomes
Down-Regulation
Ligands
35 Citations (Scopus)

Recent advances in molecular imaging biomarkers in cancer: application of bench to bedside technologies

van der Meel, R., Gallagher, W. M., Oliveira, S., O'Connor, A. E., Schiffelers, R. M. & Byrne, A. T., 1 Feb 2010, In : Drug Discovery Today. 15, 3-4, p. 102-114 13 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Point-of-Care Systems
Molecular Imaging
Tumor Biomarkers
Biomarkers
Biological Phenomena
2006
8 Citations (Scopus)

Controlling cardiomyocyte survival

de Jonge, N., Goumans, M. J., Lips, D., Hassink, R., Vlug, E. J., van der Meel, R., Emmerson, C. D., Nijman, J., de Windt, L. & Doevendans, P. A., 1 Dec 2006, Heart Failure: Molecules, Mechanisms and Therapeutic Targets: Molecules, Mechanisms and Therapeutic Targets. Bock, G. & Goode, J. (eds.). Chichester: Wiley, p. 41-51 11 p. (Novartis Foundation Symposium; vol. 274)

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Cardiac Myocytes
Hypertrophy
Apoptosis
Left Ventricular Function
Cellular Microenvironment