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Personal profile

Research profile

Roy van der Meel is Assistant Professor of Precision Medicine at the TU/e's Biomedical Engineering department. His research is focused on developing RNA-based nanotherapeutics to regulate the immune response in a highly precise manner.

Academic background

Roy van der Meel studied Biomedical Sciences and Drug Innovation at Utrecht University in The Netherlands where he obtained his M.Sc. degree in 2009. He then conducted his Ph.D. research at the Utrecht University Pharmaceutics Department under supervision of Wim Hennink, Gert Storm, Robbert Jan Kok and Raymond Schiffelers. Roy's research focused on developing nanomedicines to inhibit tumor growth and angiogenesis and he obtained his Ph.D. degree in 2013. After obtaining Marie Skłodowska-Curie Action funding from the European Commission and a Veni grant from the Netherlands Organization for Scientific Research, Roy conducted postdoctoral research in the labs of Raymond Schiffelers (University Medical Center Utrecht) and Pieter Cullis (University of British Columbia, Vancouver, BC, Canada). In 2019, Roy was appointed Assistant Professor of Precision Medicine at the TU/e's Biomedical Engineering department.

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Research Output 2006 2019

  • 1159 Citations
  • 20 Article
  • 9 Review article
  • 1 Conference contribution
  • 1 Phd Thesis 4 Research NOT TU/e / Graduation NOT TU/e)
4 Citations (Scopus)

Fusion-dependent formation of lipid nanoparticles containing macromolecular payloads

Kulkarni, J. A., Witzigmann, D., Leung, J., van der Meel, R., Zaifman, J., Darjuan, M. M., Grisch-Chan, H. M., Thöny, B., Tam, Y. Y. C. & Cullis, P. R., 14 May 2019, In : Nanoscale. 11, 18, p. 9023-9031 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Lipids
Fusion reactions
Nanoparticles
Polyethylene glycols
Gene therapy

Lipid nanoparticle technology for clinical translation of siRNA therapeutics

Kulkarni, J. A., Witzigmann, D., Chen, S., Cullis, P. R. & van der Meel, R., 9 Aug 2019, In : Accounts of Chemical Research. 52, 9, p. 2435-2444

Research output: Contribution to journalReview articleAcademicpeer-review

Small Interfering RNA
Nanoparticles
Lipids
Genes
Prealbumin

Smart cancer nanomedicine

van der Meel, R., Sulheim, E., Shi, Y., Kiessling, F., Mulder, W. & Lammers, T., 6 Nov 2019, In : Nature Nanotechnology. 14, p. 1007–1017 11 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Medical nanotechnology
cancer
therapy
drugs
stratification
27 Citations (Scopus)

Lipid nanoparticles enabling gene therapies: from concepts to clinical utility

Kulkarni, J. A., Cullis, P. R. & van der Meel, R., Jun 2018, In : Nucleic Acid Therapeutics. 28, 3, p. 146-157 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Genetic Therapy
Nanoparticles
Lipids
Small Interfering RNA
Clustered Regularly Interspaced Short Palindromic Repeats
19 Citations (Scopus)

On the formation and morphology of lipid nanoparticles containing Ionizable cationic lipids and siRNA

Kulkarni, J. A., Darjuan, M. M., Mercer, J. E., Chen, S., van der Meel, R., Thewalt, J. L., Tam, Y. Y. C. & Cullis, P. R., 22 May 2018, In : ACS Nano. 12, 5, p. 4787-4795 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Lipids
Small Interfering RNA
lipids
Nanoparticles
nanoparticles

Prizes

Nanomedicine
Castration
Routine Diagnostic Tests
Prostatic Neoplasms
docetaxel

Marie Skłodowska-Curie Action (Global Fellowship)

Roy van der Meel (Recipient), 2 Apr 2015

Recognition: OtherFellowships & membershipsScientific

Prostatic Neoplasms
Castration
Nanomedicine
Biomarkers
Therapeutics

Activities 2018 2019

  • 4 Invited talk

A modular nanocarrier platform for delivery of siRNA and lipophilic prodrugs

Roy van der Meel (Speaker)
5 Feb 2019

Activity: Talk or presentation typesInvited talkScientific

Lipid nanoparticles enabling personalized vaccines for cancer immunotherapy

Roy van der Meel (Speaker)
16 Jan 2019

Activity: Talk or presentation typesInvited talkScientific

The Flying Dutchman: Managing an MSCA research project in Canada

Roy van der Meel (Speaker)
5 Nov 2018

Activity: Talk or presentation typesInvited talkProfessional

Nucleic acid nanobiologics to regulate trained immunity

Roy van der Meel (Speaker)
25 Sep 2018

Activity: Talk or presentation typesInvited talkScientific