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Personal profile

Research profile

Roy van der Meel is Assistant Professor of Precision Medicine at the TU/e's Biomedical Engineering department. His research is focused on developing RNA-based nanotherapeutics to regulate the immune response in a highly precise manner.

Academic background

Roy van der Meel studied Biomedical Sciences and Drug Innovation at Utrecht University in The Netherlands where he obtained his M.Sc. degree in 2009. He then conducted his Ph.D. research at the Utrecht University Pharmaceutics Department under supervision of Wim Hennink, Gert Storm, Robbert Jan Kok and Raymond Schiffelers. Roy's research focused on developing nanomedicines to inhibit tumor growth and angiogenesis and he obtained his Ph.D. degree in 2013. After obtaining Marie Skłodowska-Curie Action funding from the European Commission and a Veni grant from the Netherlands Organization for Scientific Research, Roy conducted postdoctoral research in the labs of Raymond Schiffelers (University Medical Center Utrecht) and Pieter Cullis (University of British Columbia, Vancouver, BC, Canada). In 2019, Roy was appointed Assistant Professor of Precision Medicine at the TU/e's Biomedical Engineering department.

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  • 3 Similar Profiles
Single-Domain Antibodies Medicine & Life Sciences
Small Interfering RNA Medicine & Life Sciences
Nanomedicine Medicine & Life Sciences
Epidermal Growth Factor Receptor Medicine & Life Sciences
Nanoparticles Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Liposomes Medicine & Life Sciences
Drug Delivery Systems Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2006 2020

Modular lipid nanoparticle platform technology for siRNA and lipophilic prodrug delivery

van der Meel, R., Chen, S., Zaifman, J., Kulkarni, J. A., Zhang, X. R. S., Tam, Y. K., Bally, M. B., Schiffelers, R. M., Ciufolini, M. A., Cullis, P. R. & Tam, Y. Y. C., 16 Jan 2020, In : bioRxiv. 20 p.

Research output: Contribution to journalArticleAcademic

Open Access
File
Prodrugs
Nanoparticles
Small Interfering RNA
Technology
Lipids
7 Citations (Scopus)

Fusion-dependent formation of lipid nanoparticles containing macromolecular payloads

Kulkarni, J. A., Witzigmann, D., Leung, J., van der Meel, R., Zaifman, J., Darjuan, M. M., Grisch-Chan, H. M., Thöny, B., Tam, Y. Y. C. & Cullis, P. R., 14 May 2019, In : Nanoscale. 11, 18, p. 9023-9031 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Lipids
Fusion reactions
Nanoparticles
Polyethylene glycols
Gene therapy
1 Citation (Scopus)

Lipid nanoparticle technology for clinical translation of siRNA therapeutics

Kulkarni, J. A., Witzigmann, D., Chen, S., Cullis, P. R. & van der Meel, R., 17 Sep 2019, In : Accounts of Chemical Research. 52, 9, p. 2435-2444 10 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Small Interfering RNA
Nanoparticles
Lipids
Genes
Prealbumin
1 Citation (Scopus)
1 Downloads (Pure)

Smart cancer nanomedicine

van der Meel, R., Sulheim, E., Shi, Y., Kiessling, F., Mulder, W. & Lammers, T., 6 Nov 2019, In : Nature Nanotechnology. 14, 11, p. 1007–1017 11 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Medical nanotechnology
cancer
therapy
drugs
stratification
1 Citation (Scopus)

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

Akinc, A., Maier, M. A., Manoharan, M., Fitzgerald, K., Jayaraman, M., Baros, S., Ansell, S., Du, X., Hope, M. J., Madden, T. D., Mui, B. L., Semple, S. C., Tam, Y. K., Ciufolini, M. A., Witzigmann, D., Kulkarni, J. A., van der Meel, R. & Cullis, P. R., 4 Dec 2019, In : Nature Nanotechnology. 14, 12, p. 1084-1087 4 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

Medical nanotechnology
Nucleic acids
nucleic acids
Nucleic Acids
drugs

Prizes

Nanomedicine
Castration
Routine Diagnostic Tests
Prostatic Neoplasms
docetaxel

Marie Skłodowska-Curie Action (Global Fellowship)

Roy van der Meel (Recipient), 2 Apr 2015

Prize: OtherFellowships & membershipsScientific

Castration
Prostatic Neoplasms
Nanomedicine
Biomarkers
docetaxel

Activities 2018 2019

  • 4 Invited talk

A modular nanocarrier platform for delivery of siRNA and lipophilic prodrugs

Roy van der Meel (Speaker)
5 Feb 2019

Activity: Talk or presentation typesInvited talkScientific

Lipid nanoparticles enabling personalized vaccines for cancer immunotherapy

Roy van der Meel (Speaker)
16 Jan 2019

Activity: Talk or presentation typesInvited talkScientific

The Flying Dutchman: Managing an MSCA research project in Canada

Roy van der Meel (Speaker)
5 Nov 2018

Activity: Talk or presentation typesInvited talkProfessional

Nucleic acid nanobiologics to regulate trained immunity

Roy van der Meel (Speaker)
25 Sep 2018

Activity: Talk or presentation typesInvited talkScientific