• 1 Citations
20192019
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Personal profile

Research profile

Roxanne received her BSc in Biological Sciences and MSc in Virology at Imperial College London, UK. Following this, she then joined the Florey Institute for Host-Pathogen Interactions at the University of Sheffield, UK, where she pursued her PhD under the supervision of Professor Jon Sayers. There, she undertook an interdisciplinary research project, studying bacterial replication enzymes as potential targets for novel antibiotics. 

 

Roxanne joined Christian Ottmann’s group as a postdoctoral researcher in early drug discovery in November 2017, at TU/e in collaboration with GSK. Her research focuses on a new anti-inflammatory drug approach via the identification of small molecule stabilisers of the 14-3-3/pyrin complex, key regulators in the innate immune response.

Fingerprint Dive into the research topics where Roxanne Lau is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 1 Similar Profiles
14-3-3 Proteins Chemical Compounds
Phosphorylation Chemical Compounds
AMP-Activated Protein Kinases Chemical Compounds
Protein Kinases Chemical Compounds
Transcription Factors Chemical Compounds
Forkhead Transcription Factors Chemical Compounds
Protein-Serine-Threonine Kinases Chemical Compounds
Post Translational Protein Processing Medicine & Life Sciences

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Research Output 2019 2019

  • 1 Citations
  • 1 Article
1 Citation (Scopus)

AMPK and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14-3-3 proteins

Saline, M., Badertscher, L., Wolter, M., Lau, R., Gunnarsson, A., Jacso, T., Norris, T., Ottmann, C. & Snijder, A., 30 Aug 2019, In : Journal of Biological Chemistry. 294, 35, p. 13106-13116 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

14-3-3 Proteins
Phosphorylation
AMP-Activated Protein Kinases
Protein Kinases
Transcription Factors