• 18 Citations
20172018

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Personal profile

Research profile

Roxane is a PhD student at the Eindhoven University of Technology (TU/e), in the group of Bio-Organic Chemistry (Jan van Hest). Her subject is 'Polymeric Nanoparticles Shape Effects in a Drug Delivery Context', with a focus on ocular drug delivery via intravitreal injection. The objective is to evaluate the effect of polymeric micelles and vesicles shape and surface charge on drug loading, drug release, cellular interaction and biodistribution in the eye. Therefore, research lines are polymer synthesis (amphiphilic block copolymers) and characterization, polymeric nanoparticle formulation (self-assembly via direct hydration and solvent-switch methods) and characterization, drug loading and release, pharmacokinetics, in vitro and ex-vivo evaluations.

We will provide an answer on the following: How to build biocompatible drug delivery systems with different shapes? Which type of nanoparticle will have the best shape as a nanomedicine functioning in a biomedical context?

Quote

I love to work in a multidisciplinary field, so Nanomedicine is ideal ! My goal is to study the effect of the shape and surface charge of nanoparticles in an ocular drug delivery context.

Academic background

Born and raised in France, Roxane has developed a passion for nanomedicine. Before graduating in 2016 with a MSc in Chemistry and Physics with a speciality in polymers and formulation from Ecole Nationale Supérieure de Chimie, Biologie et Physique de Bordeaux (Pessac, France), Roxane did two internships working on drug delivery systems. First, she worked in the Pr. Vincent Rotello’s group at UMASS (Amherst, Massachusetts, USA), where she developed polymer-based nanospheres for delivery applications (cancer therapy and biofilm treatment). Then, she joined the Pr. Jan van Hest’s group at the Radboud University (Nijmegen, The Netherlands), where she worked on biodegradable polymer-based micelles formulation and characterization for drug delivery to treat leukemia.

Since September 2016, Roxane is a PhD student at TU/e (Eindhoven, NL), in the Bio-Organic Chemistry group of Pr. Jan van Hest. Her project is called Particle Shape Effect and takes part of the European framework NANOMED.

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Research Output

  • 18 Citations
  • 2 Article

Biodegradable, drug-loaded nanovectors via direct hydration as a new platform for cancer therapeutics

Ridolfo, R., Ede, B. C., Diamanti, P., White, P. B., Perriman, A. W., van Hest, J. C. M., Blair, A. & Williams, D. S., 9 Aug 2018, In : Small. 14, 32, 10 p., 1703774.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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  • 4 Citations (Scopus)
    46 Downloads (Pure)

    Controlling the morphology of copolymeric vectors for next generation nanomedicine

    Williams, D. S., Pijpers, I. A. B., Ridolfo, R. & van Hest, J. C. M., 10 Aug 2017, In : Journal of Controlled Release. 259, 10 august 2016, p. 29-39 11 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    File
  • 14 Citations (Scopus)
    104 Downloads (Pure)